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Information on EC - clavaminate synthase

for references in articles please use BRENDA:EC1.14.11.21
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IUBMB Comments
Contains nonheme iron. Catalyses three separate oxidative reactions in the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC, proclavaminate amidinohydrolase. The three reactions are all catalysed at the same nonheme iron site.
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The enzyme appears in viruses and cellular organisms
CAS, CAS1, CAS2, clavaminate synthase 1, clavaminate synthase 2, clavaminic acid synthase, CS, synthase, clavaminate, more
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2
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dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O
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proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O
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