Disease on EC 1.13.11.71 - carotenoid-9',10'-cleaving dioxygenase

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DISEASE
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Autoimmune Diseases
The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes.
UBE2L3 Polymorphism Amplifies NF-?B Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases.
Carcinogenesis
Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.
Carcinoma, Hepatocellular
MicroRNA miR-147b promotes tumor growth via targeting UBE2N in hepatocellular carcinoma.
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
UBE2T promotes hepatocellular carcinoma cell growth via ubiquitination of p53.
Crohn Disease
Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.
Fanconi Anemia
Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination.
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.
Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T.
Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.
The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair.
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.
UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2.
Hemochromatosis
UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis.
Hepatitis
UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.
Herpes Simplex
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
Huntington Disease
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
Infection
A functional variant in UBE2L3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC3A protein.
Leukemia
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
Liver Diseases
Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice.
Lung Neoplasms
Elevated expression of UBE2T in lung cancer tumors and cell lines.
Lupus Erythematosus, Systemic
A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.
Effect of UBE2L3 genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus.
The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes.
Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population.
Melanoma
UBE2N plays a pivotal role in maintaining melanoma malignancy.
UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling.
Multiple Myeloma
High expression of UBE2T predicts poor prognosis and survival in multiple myeloma.
Nasopharyngeal Carcinoma
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3?/?-catenin pathway.
Neoplasm Metastasis
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3?/?-catenin pathway.
Neoplasms
Elevated expression of UBE2T in lung cancer tumors and cell lines.
MicroRNA miR-147b promotes tumor growth via targeting UBE2N in hepatocellular carcinoma.
UBE2N plays a pivotal role in maintaining melanoma malignancy.
Neuroblastoma
A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways.
Non-alcoholic Fatty Liver Disease
Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice.
Osteosarcoma
Knockdown of UBE2T Inhibits Osteosarcoma Cell Proliferation, Migration, and Invasion by Suppressing the PI3K/Akt Signaling Pathway.
Prostatic Neoplasms
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Scleroderma, Diffuse
Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.
Scleroderma, Systemic
Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.
Stomach Neoplasms
UBE2T knockdown inhibits gastric cancer progression.
Thyroiditis
The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.
Urinary Bladder Neoplasms
UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells.