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Information on EC 1.13.11.51 - 9-cis-epoxycarotenoid dioxygenase
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1.13.11.51 9-cis-epoxycarotenoid dioxygenaseIUBMB Comments
Requires iron(II). Acts on 9-cis-violaxanthin and 9'-cis-neoxanthin but not on the all-trans isomers [2,3]. In vitro, it will cleave 9-cis-zeaxanthin. Catalyses the first step of abscisic-acid biosynthesis from carotenoids in chloroplasts, in response to water stress. The other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase].
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Word Map
- 1.13.11.51
-
abscisic
- drought
-
nceds
-
phytohormone
-
ripening
-
stomatal
-
apocarotenoids
- zeaxanthin
-
8'-hydroxylase
-
dormancy
-
drought-induced
-
epoxidase
-
aba-dependent
-
aba-deficient
- carotene
- phytoene
-
aba-responsive
- strigolactones
-
aba-induced
-
aba-mediated
-
water-stressed
-
non-climacteric
- fluridone
-
aba-related
-
norisoprenoids
-
carotenoid-derived
- beta-ionone
- crocus
- xanthoxin
- violaxanthin
- agriculture
-
carotenogenic
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
=
+
+
=
+
Synonyms
9-cis-epoxycarotenoid dioxygenase, nced3, atnced3, nced1, nced2, nced5, nced9, lenced1, sgnced1, vvnced1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
9,10[9',10']carotenoid cleavage dioxygenase
9-cis epoxycarotenoid dioxygenase
9-cis-epoxcarotenoid dioxygenase
9-cis-epoxycarotenoid dioxygenase
9-cis-epoxycarotenoid dioxygenase 3
9-cis-epoxycarotenoid dioxygenase 6
9-cis-epoxycarotenoid dioxygenase1
9-cis-epoxycarotenoid dioxygenase4
AtNCED3
B-diox-II
carotenoid cleavage dioxygenase 1
CCD1
CitNCED2
CitNCED3
LeNCED1
NCED
NCED1
NCED2
NCED3
NCED4
NCED5
NCED6
NSC1
PvNCED1
VP14
VvNCED1
9-cis-epoxcarotenoid dioxygenase
key enzyme in abscisic acid biosynthesis and in fruit ripening
9-cis-epoxcarotenoid dioxygenase
key enzyme in abscisic acid biosynthesis and in fruit ripening
9-cis-epoxcarotenoid dioxygenase
key enzyme in abscisic acid biosynthesis and in fruit ripening
9-cis-epoxcarotenoid dioxygenase
C5H805, O24023
key enzyme in abscisic acid biosynthesis and in fruit ripening
9-cis-epoxcarotenoid dioxygenase
key enzyme in abscisic acid biosynthesis and in fruit ripening
9-cis-epoxycarotenoid dioxygenase
-
key enzyme of abscisic acid biosynthesis
9-cis-epoxycarotenoid dioxygenase
involved in isoprenoid biosynthetic pathway
9-cis-epoxycarotenoid dioxygenase
involved in abscisic acid biosynthesis
9-cis-epoxycarotenoid dioxygenase
involved in abscisic acid biosynthesis
9-cis-epoxycarotenoid dioxygenase 3
involved in abscisic acid biosynthesis
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C-C-bond cleavage
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SYSTEMATIC NAME
IUBMB Comments
9-cis-epoxycarotenoid 11,12-dioxygenase
Requires iron(II). Acts on 9-cis-violaxanthin and 9'-cis-neoxanthin but not on the all-trans isomers [2,3]. In vitro, it will cleave 9-cis-zeaxanthin. Catalyses the first step of abscisic-acid biosynthesis from carotenoids in chloroplasts, in response to water stress. The other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase].
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CAS REGISTRY NUMBER
COMMENTARY
199877-10-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-hydroxy alpha-apo-10'-carotenoid acid + O2
cyclohexenone + mycorradicin
-
-
-
-
?
3-OH-beta-apo-10'-carotenal + O2
apo-10',10-apocarotene-dial + ?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
3-OH-beta-apo-8'-carotenal + O2
apo-8',10-apocarotene-dial
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
4-hydroxymyxol 2'-fucoside + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
4-ketomyxol 2'-fucoside + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
9'-cis-neoxanthin + O2
5,6-epoxy-3-hydroxy-12'-apo-beta-caroten-12'-al + 3,5-dihydroxy-6,7-didehydro-12'-apo-beta-caroten-12'-al + ?
-
-
-
-
?
9-cis-neoxanthin + O2
xanthoxin + ?
-
assay at pH 6.7, 22°C, 20 min, reaction stopped by adding 50 microl of 25% Triton X-100
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
9-cis-violaxanthin + O2
5,6-epoxy-3-hydroxy-12'-apo-beta-caroten-12'-al + 5,6-epoxy-3-hydroxy-9-apo-beta-caroten-9-one + ?
-
-
-
-
?
a 9-cis-epoxycarotenoid + O2
2-cis,4-trans-xanthoxin + a 12'-apo-carotenal
-
-
-
?
astaxanthin + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
beta,beta-carotene + O2
4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + 3-hydroxy-9-apo-beta-caroten-9-one + ?
-
-
-
-
?
beta-apo-10'-carotenal + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
beta-carotene + O2
strigolactone + ?
-
two cleavage steps by CCD7 and CCD8
-
-
?
canthaxanthin + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
echinenone + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
gamma-carotene + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
lutein + O2
4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + ?
-
-
-
-
?
myxol + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
myxol 2'-fucoside + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
drought-induced biosynthesis of abscisic acid is regulated by the 9-cis-epoxy-carotenoid cleavage reaction
-
-
?
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
CitCCD1
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
-
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
drought-induced biosynthesis of abscisic acid is regulated by the 9-cis-epoxy-carotenoid cleavage reaction
-
-
?
all-trans-violaxanthin + O2
4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + ?
-
-
-
-
?
all-trans-violaxanthin + O2
4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + ?
-
-
-
?
all-trans-violaxanthin + O2
4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + ?
-
-
-
?
all-trans-violaxanthin + O2
4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + ?
-
-
-
?
beta-apo-8'-carotenal + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
zeaxanthin + O2
4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + ?
-
-
-
-
?
zeaxanthin + O2
4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + ?
-
-
-
?
zeaxanthin + O2
4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + ?
-
-
-
?
zeaxanthin + O2
4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial + ?
-
-
-
?
zeaxanthin + O2
?
assay at pH 7.8, 28°C, incubation stopped by adding one volume of acetone
-
-
?
additional information
?
-
-
key enzyme in the abscisic acid biosynthetic pathway
-
-
?
additional information
?
-
different mutants: mutations in genes involved in the ethylene signal transduction pathway and a mutation at the start of exon 2
-
-
?
additional information
?
-
-
different mutants: mutations in genes involved in the ethylene signal transduction pathway and a mutation at the start of exon 2
-
-
?
additional information
?
-
-
key regulatory enzyme in abscisic acid biosynthesis in leaves
-
-
?
additional information
?
-
-
expression is strongly induced by drought stress in the 8-day old plant. The enzyme has a key role in the synthesis of abscisic acid under drought stress
-
-
?
additional information
?
-
-
key enzyme involved in the biosynthetic pathway of abscisic acid
-
-
?
additional information
?
-
the enzyme functions in root and leaf in abscisic acid synthesis
-
-
?
additional information
?
-
-
the enzyme functions in root and leaf in abscisic acid synthesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
9'-cis-neoxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al
drought-induced biosynthesis of abscisic acid is regulated by the 9-cis-epoxy-carotenoid cleavage reaction
-
-
?
9-cis-violaxanthin + O2
2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
drought-induced biosynthesis of abscisic acid is regulated by the 9-cis-epoxy-carotenoid cleavage reaction
-
-
?
a 9-cis-epoxycarotenoid + O2
2-cis,4-trans-xanthoxin + a 12'-apo-carotenal
-
-
-
?
additional information
?
-
-
key enzyme in the abscisic acid biosynthetic pathway
-
-
?
additional information
?
-
different mutants: mutations in genes involved in the ethylene signal transduction pathway and a mutation at the start of exon 2
-
-
?
additional information
?
-
-
different mutants: mutations in genes involved in the ethylene signal transduction pathway and a mutation at the start of exon 2
-
-
?
additional information
?
-
-
key regulatory enzyme in abscisic acid biosynthesis in leaves
-
-
?
additional information
?
-
-
expression is strongly induced by drought stress in the 8-day old plant. The enzyme has a key role in the synthesis of abscisic acid under drought stress
-
-
?
additional information
?
-
-
key enzyme involved in the biosynthetic pathway of abscisic acid
-
-
?
additional information
?
-
the enzyme functions in root and leaf in abscisic acid synthesis
-
-
?
additional information
?
-
-
the enzyme functions in root and leaf in abscisic acid synthesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(1R,3S,6R)-(3'Z)-1,5,5-trimethyl-6-(3'-methyl-5'-(phenylamino)-pent-3'-en-1'-ynyl)-7-oxabicyclo[4.1.0]heptan-3-ol