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EC Tree
IUBMB Comments Enzymes from the plants Tecoma stans, Jasminum grandiflorum and Zea mays are flavoproteins containing copper. They are part of enzyme systems that form either anthranil (2,1-benzoisoxazole) (Tecoma stans), anthranilate (Jasminum grandiflorum) or both (Zea mays) as the final product. A second enzyme from Tecoma stans is not a flavoprotein, does not require copper, and is part of a system that forms anthranilate as the final product.
The enzyme appears in viruses and cellular organisms
Synonyms
indole 2,3-dioxygenase,
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indole 2,3-dioxygenase
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indole:O2 oxidoreductase
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indoleamine 2,3-dioxygenase
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oxygenase, indole 2,3-di-
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IDO
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indole + O2 = 2-formylaminobenzaldehyde
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indole:oxygen 2,3-oxidoreductase (decyclizing)
Enzymes from the plants Tecoma stans, Jasminum grandiflorum and Zea mays are flavoproteins containing copper. They are part of enzyme systems that form either anthranil (2,1-benzoisoxazole) (Tecoma stans), anthranilate (Jasminum grandiflorum) or both (Zea mays) as the final product. A second enzyme from Tecoma stans is not a flavoprotein, does not require copper, and is part of a system that forms anthranilate as the final product.
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5-bromoindole + O2
5-bromo-2-formylaminobenzaldehyde
5-hydroxyindole + O2
2-formylamino-5-hydroxybenzaldehyde
5-methylindole + O2
2-formylamino-5-methylbenzaldehyde
indole + O2
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during daytime activity is less, it reaches a peak during nighttime
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indole + O2
anthranilic acid
o-aminobenzaldehyde + O2
anthranilic acid
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5-bromoindole + O2
5-bromo-2-formylaminobenzaldehyde
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5-bromoindole + O2
5-bromo-2-formylaminobenzaldehyde
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5-bromoindole + O2
5-bromo-2-formylaminobenzaldehyde
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15% of the activity with indole
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5-hydroxyindole + O2
2-formylamino-5-hydroxybenzaldehyde
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5-hydroxyindole + O2
2-formylamino-5-hydroxybenzaldehyde
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5-hydroxyindole + O2
2-formylamino-5-hydroxybenzaldehyde
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20% of the activity with indole
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5-methylindole + O2
2-formylamino-5-methylbenzaldehyde
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5-methylindole + O2
2-formylamino-5-methylbenzaldehyde
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26% of the activity with indole
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indole + O2
anthranilic acid
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conversion of indole to anthranilic acid
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indole + O2
anthranilic acid
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final product is anthranil, formylaminobenzaldehyde and o-aminobenzaldehyde are intermediates, 3 atoms of oxygen are consumed in the formation of anthranil from one molecule of indole
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indole + O2
anthranilic acid
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conversion of indole to anthranilic acid
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indole + O2
anthranilic acid
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conversion of indole to anthranilic acid
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indole + O2
anthranilic acid
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4 atoms of oxygen utilized in disappearance of 1 mol of indole, 2 atoms of oxygen required for initial cleavage of indole and one each for the oxidation of o-aminobenzaldehyde to anthranil and anthranilic acid, simultaneously
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indole + O2
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during daytime activity is less, it reaches a peak during nighttime
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FAD
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slight stimulation
FAD
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absolute requirement for maximal activity
FAD
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reconstitution of enzyme activity after dialysis by FAD and Cu2+
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Cu2+
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reconstitution of enzyme activity after dialysis by FAD and Cu2+
Cu2+
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absolute requirement for maximal activity
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CO
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0.5 mM, 58% inhibition
Cu2+
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1 mM, CuSO4, 25% inhibition
dithiothreitol
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0.0005 mM, 97% inhibition
iodoacetate
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0.0005 mM, 19% inhibition
Neocuproine
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0.001 mM, 92% inhibition
2-mercaptoethanol
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0.0005 mM, 64.5% inhibition
2-mercaptoethanol
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0.5 mM, 80% inhibition, Cu2+ protects
8-hydroxyquinoline
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0.001 mM, 48% inhibition
8-hydroxyquinoline
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0.5 mM, 40% inhibition
Atebrin
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0.5 mM, 80% inhibition
azide
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0.5 mM, 54% inhibition
cyanide
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0.5 mM, 64% inhibition
Cys
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Cu2+ can completely reverse inhibition
Cys
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0.5 mM, 78% inhibition, Cu2+ protects
diethyldithiocarbamate
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0.001 mM, 74% inhibition
diethyldithiocarbamate
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0.5 mM, 60% inhibition, Cu2+ can completely reverse inhibition
diethyldithiocarbamate
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diethyldithiocarbamate
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reversed by Cu2+
Dithionite
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Dithionite
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1 mM, almost complete inhibition
Fe2+
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0.0005 mM, 55% inhibition
Fe2+
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1 mM, FeSO4, 50% inhibition
Fe2+
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0.5 mM FeSO4, 35% inhibition
Fe2+
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0.5 mM, 35% inhibition
Fe2+
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0.5 mM, slight inhibition
Fe3+
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Fe3+
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0.5 mM Fe2(SO4)3, 50% inhibition
Fe3+
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0.5 mM, slight inhibition
GSH
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0.0005 mM, 94% inhibition
GSH
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Cu2+ can completely reverse inhibition
GSH
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0.5 mM, 81% inhibition, Cu2+ protects
Hg2+
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0.5 mM HgCl2, 30% inhibition
Hg2+
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0.5 mM, slight inhibition
NEM
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0.0005 mM, 87.5% inhibition
NEM
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0.5 mM, 34% inhibition
PCMB
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0.0005 mM, 98.5% inhibition
PCMB
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0.5 mM, 30% inhibition, Cu2+ can completely reverse inhibition
Salicylaldoxime
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0.001 mM, 61% inhibition
Salicylaldoxime
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0.5 mM, 62% inhibition
Salicylaldoxime
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0.5 mM, 34% inhibition
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Infections
Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases.
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0.0189
indole
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0.0157
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disappearance of 1 nmol indole in 1 min
0.0441
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disappearance of 1 nmol indole in 1 min
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5
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3.8 - 6.2
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pH 3.8: about 80% of maximal activity, pH 5.8: about 65% of maximal activity, pH 6.2: about 30% of maximal activity
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30
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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with or without Epstein-Barr virus infection
brenda
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brenda
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activity is present in relevant amounts even in newborn rats. The specific activity increases significantly in young rats by about 44% in comparison to newborns
brenda
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brenda
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brenda
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middle leaves
brenda
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brenda
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physiological function
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increased enzyme expression in plasmablastic lymphoma, a rare and aggressive diffuse large B-cell lymphoma commonly associated with Epstein-Barr virus co-infection that most often occurs in the context of human immunodeficiency virus infection. The enzyme acts as immunosuppressive molecule and is involved in the tumor immune escape mechanism
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D8LIV6_ECTSI
498
0
53184
TrEMBL
other Location (Reliability: 3 )
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dialysis results in complete loss of activity
dialysis, 8 h, results in complete loss of activity
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pH 7, 0.02 M sodium phosphate buffer, 0.1 mM EDTA, 6 h in the cold, slight loss of activity
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dialysis results in complete loss of activity
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dialysis results in complete loss of activity
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-20°C, 18 h without appreciable loss of activity, complete loss of activity after 48 h
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-20°C, 20 d, no appreciable loss of activity
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4°C, stable for 2 weeks
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increased enzyme expression via expression of CD163 antigen in plasmablastic lymphoma, a rare and aggressive diffuse large B-cell lymphoma commonly associated with Epstein-Barr virus co-infection that most often occurs in the context of human immunodeficiency virus infection
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Pundir, C.S.; Garg, G.K.; Rathore, V.S.
Purification and properties of indole 2,3-dioxygenase from maize leaves
Phytochemistry
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2423-2427
1984
Zea mays
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brenda
Kunapuli, S.P.; Vaidyanathan, C.S.
Purification and characterization of a new indole oxygenase from the leaves of Tecoma stans L
Plant Physiol.
71
19-23
1983
Tecoma stans
brenda
Madhusudanan Nair, P.; Vaidyanathan, C.S.
An indole oxidase isolated from the leaves of Tecoma stans
Biochim. Biophys. Acta
81
496-506
1964
Tecoma stans
brenda
Divakar, N.G.; Subramanian, V.; Sugumaran, M.; Vaidyanathan, C.S.
Indole oxygenase from the leaves of Jasminum grandiflorum
Plant Sci. Lett.
15
177-181
1979
Jasminum grandiflorum
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brenda
Kunapuli, S.P.; Vaidyanathan, C.S.
Indole oxygenase from the leaves of Tecoma stans
Plant Sci. Lett.
24
183-188
1982
Tecoma stans
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brenda
Comai, S.; Costa, C.V.; Ragazzi, E.; Bertazzo, A.; Allegri, G.
The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats
Clin. Chim. Acta
360
67-80
2005
Rattus norvegicus
brenda
Laurent, C.; Fabiani, B.; Do, C.; Tchernonog, E.; Cartron, G.; Gravelle, P.; Amara, N.; Malot, S.; Palisoc, M.M.; Copie-Bergman, C.; Glehen, A.T.; Copin, M.C.; Brousset, P.; Pittaluga, S.; Jaffe, E.S.; Coppo, P.
Immune-checkpoint expression in Epstein-Barr virus positive and negative plasmablastic lymphoma a clinical and pathological study in 82 patients
Haematologica
101
976-984
2016
Homo sapiens
brenda
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