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Disease on EC 1.13.11.12 - linoleate 13S-lipoxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia.
Acne Vulgaris
Exploration of retinoid activity and the role of inflammation in acne: issues affecting future directions for acne therapy.
Acute Lung Injury
Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury.
Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats.
Mediators of lung injury in mice following systemic activation of complement.
Adenocarcinoma
15-lipoxygenase-1 overexpression in prostate adenocarcinoma.
15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma.
Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging.
Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway.
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
Novel 3-aryl-5-substituted-coumarin analogues: Synthesis and bioactivity profile.
The role of 15-lipoxygenase-1 expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas.
Adenocarcinoma, Bronchiolo-Alveolar
Dietary lipids modulate eicosanoid release and apoptosis of cells of a murine lung alveolar carcinoma.
Adenoma
HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts.
Agranulocytosis
Synergistic inhibition of complement induced granulocyte margination by BW755C and calcium channel blockers.
Airway Obstruction
Eicosanoids modulate hyperpnea-induced late phase airway obstruction and hyperreactivity in dogs.
Reversal of A23187-induced airway constriction in the guinea pig.
Alkalosis
Involvement of lipoxygenase and cyclo-oxygenase pathways in hypoxia and metabolic alkalosis produced by canatoxin in rats.
Alzheimer Disease
Activity-Based Probes for 15-Lipoxygenase-1.
Assessment of enzyme inhibitory and antioxidant activities of lignans from Taxus baccata L.
Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide.
Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research.
Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.
Phospholipase A2 is involved in muscarinic receptor-mediated sAPPalpha release independently of cyclooxygenase or lypoxygenase activity in SH-SY5Y cells.
Salvia officinalis L. Essential Oils from Spain: Determination of Composition, Antioxidant Capacity, Antienzymatic, and Antimicrobial Bioactivities.
Thymus mastichina L. essential oils from Murcia (Spain): Composition and antioxidant, antienzymatic and antimicrobial bioactivities.
Anaphylaxis
Bronchial anaphylaxis in actively sensitized Sprague Dawley rats: studies on mediators involved.
Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs.
Cardiac anaphylaxis: Part II: The role of prostaglandins, thromboxanes and leukotrienes in C.A.
Chronological relationships between mediator release and changes in airway dynamics during an ascaris response in sensitive cynomolgus monkeys.
Diethylcarbamazine on pulmonary vascular response to endotoxin in awake sheep.
Effect of inhibition of synthesis and receptor antagonism of SRS-A in cardiac anaphylaxis.
Effects of anaphylaxis mediators on partitioned pulmonary vascular resistance during ragweed shock in dogs.
In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin.
In vitro testing for lung toxicity: a method for distinguishing between immune- and non-immune-mediated reactions to xenobiotics.
Inhibition of the release of slow-reacting substance of anaphylaxis by inhibitors of lipoxygenase activity.
Leukotrienes, thromboxane A2, and prostaglandins during systemic anaphylaxis in sheep.
Mechanism of action of 6, 7, 8, 9, 10, 12-hexahydro-azepino-[2, 1-b] quinazolin-12-one-(RLX)--a novel bronchodilator.
Ozone-induced bronchial hyperreactivity in guinea pigs is abolished by BW 755C or FPL 55712 but not by indomethacin.
Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse.
Prostaglandin-generating factor of anaphylaxis induces mucous glycoprotein release and the formation of lipoxygenase products of arachidonate from human airways.
Release of slow-reacting substance of anaphylaxis from dispersed pig lung cells: effect of cyclo-oxygenase and lipoxygenase inhibitors.
The effect of lipoxygenase inhibitors and diethylcarbamazine on the immunological release of slow reacting substance of anaphylaxis (SRS-A) from guinea-pig chopped lung.
The effect of lipoxygenase inhibitors and leukotriene antagonists on anaphylaxis.
[Brain tissue leukotrienes in cerebral ischemia and the effect of inhibitor of SRS-A release on postischemic cerebral edema]
[Lipoxygenase catalyzation of arachidonic acid metabolism and the effect of its inhibition on anaphylactic reactions]
[The effect of indomethacin on the changes in the hemodynamics and coronary vascular resistance during anaphylactic shock]
[The mechanisms of the changes in coronary vascular resistance in anaphylactic shock]
[The participation of platelets in anaphylactic shock in the rat]
Anemia
Evidence for the appearance of a reticulocyte population low in lipoxygenase mRNA during the recovery from a phenylhydrazine-induced anemia in rabbits.
In vitro maturation of rabbit reticulocytes. III. Response of lipoxygenase.
Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells.
Synthesis of non-globin proteins in rabbit-erythroid cells. Synthesis of a lipoxygenase in reticulocytes.
The biological dynamics of lipoxygenase in rabbit red cells in the course of an experimental bleeding anaemia. Unexpected effects of the calcium ionophore A 23187.
The lipoxygenase of reticulocytes. Purification, characterization and biological dynamics of the lipoxygenase; its identity with the respiratory inhibitors of the reticulocyte.
The share of lipoxygenase in the antimycin-resistant oxygen uptake of intact rabbit reticulocytes.
Anemia, Hypochromic
A role for oxidative stress in the Citrus limon/Phoma tracheiphila interaction
Deciphering the molecular mechanism behind stimulated co-uptake of arsenic and fluoride from soil, associated toxicity, defence and glyoxalase machineries in arsenic-tolerant rice.
Angina Pectoris
[Treatment of angina pectoris. New perspectives]
Arrhythmias, Cardiac
Effects of a lipoxygenase inhibitor on digoxin-induced cardiac arrhythmias in the isolated perfused guinea-pig heart.
The effect of substances influencing the arachidonic acid cascade on experimental cardiac arrhythmias.
Arteriosclerosis
[Advances in the research of lipoxygenase inhibitors]
Arthritis
5-Lipoxygenase inhibitors attenuate TNF-?-induced inflammation in human synovial fibroblasts.
Bacopa monniera (L.) wettst inhibits type ii collagen-induced arthritis in rats.
Changes in lipoxygenase products from synovial fluid in carrageenan induced arthritis in dogs.
Chemotactic leukotriene B4 activity in plasma from children with arthritis.
Docking Studies and Molecular Dynamics Simulation of Ipomoea batatas L. Leaves Compounds as Lipoxygenase (LOX) Inhibitor.
Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1.
Lipoxygenase inhibitor and colchicine as anti-arthritic agents in the rat.
Lipoxygenase products of arachidonic acid in psoriasis, atopic dermatitis, and experimental arthritis.
Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice.
The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective.
UP1306, a Botanical Composition with Analgesic and Anti-inflammatory Effect.
[Effects of methotrexate on leukotriene and derivated lipoxygenase synthesis in polynuclear neutrophils in rheumatoid polyarthritis]
[Novel synthetic method and analgesic activity of tepoxalin].
Arthritis, Experimental
[Antiphlogistic effectiveness of combinations of inhibitors of phospholipase A2, cyclooxygenase and lipoxygenases of the arachidonic acid cascade]
Arthritis, Infectious
Lipoxygenase products in experimental septic arthritis in dogs.
Arthritis, Rheumatoid
5-Lipoxygenase inhibitors attenuate TNF-?-induced inflammation in human synovial fibroblasts.
Activation of inflammation and resolution pathways of lipid mediators in synovial fluid from patients with severe rheumatoid arthritis compared with severe osteoarthritis.
Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells.
Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis.
Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Inhibition of LOX by flavonoids: a structure-activity relationship study.
Leukotriene B4, a mediator of inflammation present in synovial fluid in rheumatoid arthritis.
Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Persisting eicosanoid pathways in rheumatic diseases.
Proinflammatory lipoxygenase products from peripheral mononuclear cells in patients with rheumatoid arthritis.
Simultaneous profiling of eicosanoid metabolome in plasma by UPLC-MS/MS method: Application to identify potential makers for rheumatoid arthritis.
The effect of methotrexate on ex vivo lipoxygenase metabolism in neutrophils from patients with rheumatoid arthritis.
Arthus Reaction
Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction.
Ex vivo effects of nonsteroidal antiinflammatory drugs on arachidonic acid metabolism in neutrophils from a reverse passive Arthus reaction.
Release of eicosanoids in rat peritoneal cavity during the Arthus reaction. Effect of the PAF-antagonist BN-52021 and indomethacin.
Asthma
12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels.
12/15-lipoxygenase is an interleukin-13 and interferon-? counterregulated-mediator of allergic airway inflammation.
15-lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.
A review on herbal antiasthmatics.
Activity-Based Probes for 15-Lipoxygenase-1.
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma.
An agent that releases basophil and mast cell histamine but blocks cyclooxygenase and lipoxygenase metabolism of arachidonic acid inhibits immunoglobulin E-mediated asthma in rhesus monkeys.
An inhibitor of the lipoxygenase and cyclooxygenase pathways of arachidonic acid, 5, 8, 11, 14-eicosatetraynoic acid, inhibits immunoglobulin E mediated antigen induced monkey asthma and skin reactions.
Anti-leukotrienes in asthma: yet to arrive.
Anti-leukotrienes in Childhood Asthma.
Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae).
Aryl-acetic and cinnamic acids as lipoxygenase inhibitors with antioxidant, anti-inflammatory, and anticancer activity.
Aspirin-Intolerant Asthma: A Comprehensive Review of Biomarkers and Pathophysiology.
Aspirin-sensitive asthma.
Changes in urinary LTE4 and nasal functions following nasal provocation test with ASA in ASA-tolerant and -intolerant asthmatics.
Cyclooxygenase and lipoxygenase metabolite generation in nasal polyps.
Development of novel peptide inhibitor of Lipoxygenase based on biochemical and BIAcore evidences.
Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation.
Effect of the lipoxygenase inhibitor N-hydroxy-N-(6-methoxy-3,4-dihydro-2-naphthylmethyl)urea on bronchoconstriction and lung vascular permeability in anaphylactic guinea pigs.
Elevated plasma level of leukotrienes in bronchial asthma patients: a possible clinical relevance.
Functional and phenotypic characteristics of bronchial epithelial cells obtained by brushing from asthmatic and normal subjects.
Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1.
Genetic mechanism of aspirin-induced urticaria/angioedema.
Glutathione peroxidase activity in blood cells from aspirin-induced asthma patients.
Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1.
In vivo anti-allergic and anti-inflammatory effects of drugs that inhibit lipoxygenase activity in vitro.
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Leukotrienes, allergy and inflammation.
Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin.
Lipoxygenase inhibitory tetraketones: potential remedial source for inflammation and asthma.
Metabolomics reveals a correlation between hydroxyeicosatetraenoic acids and allergic asthma: Evidence from three years' immunotherapy.
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
New concepts in the pathogenesis of asthma.
Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase.
PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease.
Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model.
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
Role of arachidonic acid metabolites in allergen-induced late responses.
Specific enhancement of LTD4-induced contractions of isolated guinea pig trachea by 5-hydroxyeicosatetraenoic acid (5-HETE).
Sputum macrophage diversity and activation in asthma: Role of severity and inflammatory phenotype.
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
Targeted eicosanoid lipidomics of exhaled breath condensate provide a distinct pattern in the aspirin-intolerant asthma phenotype.
Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry.
The actions of 5-, 12-, and 15-HETE on tracheobronchial smooth muscle.
The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective.
The pharmacology of benoxaprofen with particular to effects on lipoxygenase product formation.
The role of leukotrienes in allergen-induced late responses in allergic sheep.
Urinary LTE4 is higher after nasal provocation test with L-ASA in bronchial than in only nasal responders.
Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma.
[Advances in the research of lipoxygenase inhibitors]
Asthma, Aspirin-Induced
Changes in urinary LTE4 and nasal functions following nasal provocation test with ASA in ASA-tolerant and -intolerant asthmatics.
Lipoxygenase pathway and hydroperoxy acids: possible relevance to aspirin-induced asthma and hyperirritability of airways in asthmatics.
Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients.
Urinary LTE4 is higher after nasal provocation test with L-ASA in bronchial than in only nasal responders.
[Asthma induced by aspirin and arachidonic acid metabolites. II. The role of leukotrienes (part four)]
Astrocytoma
mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.
Atherosclerosis
15-lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.
A leukocyte type of 12-lipoxygenase is expressed in human vascular and mononuclear cells. Evidence for upregulation by angiotensin II.
Arachidonic Acid metabolites in the cardiovascular system: the role of lipoxygenase isoforms in atherogenesis with particular emphasis on vascular remodeling.
Atherosclerosis and oxidative stress.
Atherosclerosis: the eicosanoid connection.
BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice.
Biologic relevance of lipoxygenase isoforms in atherogenesis.
Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.
Development of novel peptide inhibitor of Lipoxygenase based on biochemical and BIAcore evidences.
Differential recruitment of the coactivator proteins CREB-binding protein and steroid receptor coactivator-1 to peroxisome proliferator-activated receptor gamma/9-cis-retinoic acid receptor heterodimers by ligands present in oxidized low-density lipoprotein.
Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein.
Effect of some biologically interesting substituted tetrahydro-1,4-oxazines on drug metabolising enzymes and on inflammation.
Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells.
Enzymic lipid peroxidation--a consequence of cell injury?
Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis.
Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1.
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Hydroxyoctadecadienoic acids: novel regulators of macrophage differentiation and atherogenesis.
Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice.
Inhibition of LOX by flavonoids: a structure-activity relationship study.
Inhibition of mammalian 15-lipoxygenase-dependent lipid peroxidation in low-density lipoprotein by quercetin and quercetin monoglucosides.
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
Inhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation.
Involvement of 15-lipoxygenase in early stages of atherogenesis.
Is there a role for 15-lipoxygenase in atherogenesis?
Lipoxygenase pathways as mediators of early inflammatory events in atherosclerosis.
Lipoxygenase pathways in atherogenesis.
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Nitric oxide, peroxynitrite and lipoxygenase in atherogenesis: mechanistic insights.
Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase.
Oxidation, lipoxygenase, and atherogenesis.
Regulation of 12-lipoxygenase by cytokines in vascular smooth muscle cells.
Review: Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins.
Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model.
Role of Sandhika: a polyherbal formulation on MC3T3-E1 osteoblast-like cells.
Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.
Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective.
The effect of montelukast on atherogenesis in apoE/LDLR-double knockout mice.
The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere.
The specificity of lipoxygenase-catalyzed lipid peroxidation and the effects of radical-scavenging antioxidants.
Transgenic rabbits with the integrated human 15-lipoxygenase gene driven by a lysozyme promoter: macrophage-specific expression and variable positional specificity of the transgenic enzyme.
[Effects of modifications of lipoproteins by water soluble forms of lineoleic-hydroxamic acid on biochemical markers of development of atherosclerosis]
[Selenium and the activities of cyclooxygenase and lipoxygenase in cells involved in atherogenesis]
[Treatment of angina pectoris. New perspectives]
Autoimmune Diseases
Augmentation of 12-lipoxygenase activity of lymph node and spleen T cells in autoimmune mice MRL/1.
Azotemia
High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease.
Bacteremia
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.
Bile Reflux
Prostaglandins, H2-receptor antagonists and peptic ulcer disease.
Blindness
Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report.
Blister
Experimental otitis media with effusion induced by platelet activating factor.
Bone Resorption
First place--resident basic science award 1999. Effects of leukotriene and cyclo-oxygenase inhibition on adaptive bone remodeling in the middle ear.
Stimulation of bone resorption by lipoxygenase metabolites of arachidonic acid.
Transforming growth factor-beta modulates eicosanoid metabolism in osteogenic osteosarcoma cells.
Brain Edema
Alterations of the eicosanoid synthetic capacity of rat brain microvessels following ischemia: relevance to ischemic brain edema.
Blocking of interleukin-1 activity is a beneficial approach to ischemia brain edema formation.
Effect of MCI-186 on brain edema in rats.
Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart.
Effects of cyclooxygenase and lipoxygenase inhibitors on cerebral edema induced by freezing lesions in rats.
Effects of lipoxygenase inhibitor on cerebral edema induced by freezing lesion in rats.
Identification and quantitative analysis of hydroxy-eicosatetraenoic acids in rat brains exposed to regional ischemia.
Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger.
[Identification of 11-HETE in the rat brain and its relevancy to ischemic cerebral edema]
[Role of arachidonic acid metabolites on development of ischemic cerebral edema in rat middle cerebral artery occlusion]
Brain Injuries
Increased plasma PGE2, 6-keto-PGF1 alpha, and 12-HETE levels following experimental concussive brain injury.
Involvement of arachidonic acid metabolites in experimental brain injury. Identification of lipoxygenase products in brain. Clinical studies on prostacyclin infusion in acute cerebral ischemia.
Brain Injuries, Traumatic
Brain microvessel 12-hydroxyeicosatetraenoic acid is the (S) enantiomer and is lipoxygenase derived.
Brain Ischemia
Effect of MCI-186 on brain edema in rats.
Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart.
Effects of ebselen on cerebral ischemia and reperfusion evaluated by microdialysis.
Involvement of arachidonic acid metabolites in experimental brain injury. Identification of lipoxygenase products in brain. Clinical studies on prostacyclin infusion in acute cerebral ischemia.
Phenidone attenuates oxygen/glucose deprivation-induced neurotoxicity by antioxidant and antiapoptotic action in mouse cortical cultures.
[Brain tissue leukotrienes in cerebral ischemia and the effect of inhibitor of SRS-A release on postischemic cerebral edema]
[Role of arachidonic acid metabolites on development of ischemic cerebral edema in rat middle cerebral artery occlusion]
Brain Neoplasms
A lipoxygenase inhibitor in breast cancer brain metastases.
Breast Neoplasms
A lipoxygenase inhibitor in breast cancer brain metastases.
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Cytotoxic action of cis-unsaturated fatty acids on human cervical carcinoma (HeLa) cells: relationship to free radicals and lipid peroxidation and its modulation by calmodulin antagonists.
Cytotoxicity of arachidonic acid and of its lipoxygenase metabolite 15-hydroperoxyeicosatetraenoic acid on human breast cancer MCF-7 cells in culture.
Effects of eicosanoid synthesis inhibitors on the in vitro growth and prostaglandin E and leukotriene B secretion of a human breast cancer cell line.
Effects of linoleic acid and eicosanoid synthesis inhibitors on the growth and c-myc oncogene expression of human breast cancer cells.
In vitro effects of eicosanoid synthesis inhibitors in the presence of linoleic acid on MDA-MB-231 human breast cancer cells.
Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by epidermal growth factor.
Involvement of 15-lipoxygenase-1 in the regulation of breast cancer cell death induced by sodium butyrate.
Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis.
Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer.
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Nordihydroguaiaretic acid suppression of rat mammary carcinogenesis induced by N-methyl-N-nitrosourea.
Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture.
Regulation of the adhesion of a human breast carcinoma cell line to type IV collagen and vitronectin: roles for lipoxygenase and protein kinase C.
Requirement for autologous cancer extracts and lipoxygenation of arachidonic acid for human T-cell responses in leukocyte adherence inhibition and transmembrane potential change assays.
Role of lipoxygenases in breast cancer.
Structure Based Design and Synthesis of Peptide Inhibitor of Human LOX-12: In Vitro and In Vivo Analysis of a Novel Therapeutic Agent for Breast Cancer.
Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation.
The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells.
Unsaturated fatty acid effects on human breast cancer cell adhesion.
Bronchial Hyperreactivity
New antiasthmatic drugs from traditional medicine?
Role of arachidonic acid metabolites in allergen-induced late responses.
Bronchial Spasm
Alteration of drug responsiveness in guinea-pig lung anaphylaxis using different antigen challenge concentrations.
Analgesic-induced asthma.
Dependency of the Paf-acether induced bronchospasm on the lipoxygenase pathway in the guinea-pig.
Mechanisms of aspirin sensitivity.
The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic bronchospasm in guinea pigs.
The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation.
The influence of misoprostol (synthetic analogue of prostaglandin E1) on aspirin-induced bronchoconstriction in aspirin-sensitive asthma.
[Role of arachidonic acid (ETE) and its metabolites in the pathogenesis of bronchial spasm. II. Metabolites formed under the effect of lipoxygenase]
Bronchitis
[Interrelationship between lipoxygenase metabolites of arachidonic acid and pulmonary blood flow and ventilation in acute pneumonia]
Bronchitis, Chronic
Activity-Based Probes for 15-Lipoxygenase-1.
Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1.
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
Carcinogenesis
15-lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.
15-Lipoxygenase-1 induces lipid peroxidation and apoptosis, and improves survival in rat malignant glioma.
15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation.
15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1? expression in human colon cancer cells.
3,5-Disubstituted Isoxazole Derivatives: Potential Inhibitors of Inflammation and Cancer.
Anti-Cancer Activity of 2,4-Disubstituted Thiophene Derivatives: Dual Inhibitors of Lipoxygenase and Cyclooxygenase.
Arachidonic acid pathway: A molecular target in human testicular cancer (Review).
Aryl-acetic and cinnamic acids as lipoxygenase inhibitors with antioxidant, anti-inflammatory, and anticancer activity.
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.
Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate.
Comparative effects of piroxicam and esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets.
Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.
Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids.
Effect of LY293111 in combination with gemcitabine in colonic cancer.
Eicosanoid profiling in colon cancer: Emergence of a pattern.
Eicosanoid signaling in carcinogenesis of colorectal cancer.
Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors.
Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis.
Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling.
Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals.
Identification of a Bromodomain-like Region in 15-Lipoxygenase-1 Explains Its Nuclear Localization.
Influence of esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets.
Inhibition of lung tumorigenesis by NSAIDS: a working hypothesis.
Inhibition of two-stage skin carcinogenesis as well as complete skin carcinogenesis by oral administration of TMK688, a potent lipoxygenase inhibitor.
Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon.
Inhibitory effects of nabumetone, a cyclooxygenase-2 inhibitor, and esculetin, a lipoxygenase inhibitor, on N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats.
Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer.
Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention.
Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth.
Lipoxygenase modulation to reverse carcinogenesis.
Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis.
Overexpression of cysteinyl LT1 receptor in prostate cancer and CysLT1R antagonist inhibits prostate cancer cell growth through apoptosis.
Pharmacologically active tannins isolated from medicinal plants.
PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation.
Potential Benefits of Omega-3 Fatty Acids in Non-Melanoma Skin Cancer.
Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesis.
Prostate cancer in native Japanese and Japanese-American men: effects of dietary differences on prostatic tissue.
Relationship between cysteinyl-leukotriene-1 receptor and human transitional cell carcinoma in bladder.
Serum 5-LOX: a progressive protein marker for breast cancer and new approach for therapeutic target.
Some perspectives on dietary inhibition of carcinogenesis: studies with curcumin and tea.
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons.
The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis.
The cysteinylLT1 receptor in human renal cell carcinoma.
The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells.
The inhibitory effect of vitamin E on arachidonic acid metabolism during the process of urethane-induced lung tumorigenesis in mice.
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma.
Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer.
Therapeutic Molecular Targetingof 15-Lipoxygenase-1 in Colon Cancer.
What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
[Tumor promotion and arachidonic acid cascades]
Carcinoma
15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary.
?-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors.
Alterations in lipoxygenase and cyclooxygenase-2 catalytic activity and mRNA expression in prostate carcinoma.
Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma.
Arachidonic acid metabolism and cell proliferation in rat mammary carcinoma cells treated with indomethacin.
Arachidonic acid metabolites in saliva of patients with squamous cell carcinoma of the head and neck.
Characterization of the protein synthesis independent TNFalpha lytic mechanism in human ovarian and cervical carcinoma cell lines.
Cyclooxygenase and lipoxygenase inhibitors as modulators of cancer therapies.
Enhanced endothelial cell retraction mediated by 12(S)-HETE: a proposed mechanism for the role of platelets in tumor cell metastasis.
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma.
Inhibition of head and neck tumor cell growth with arachidonic acid metabolism inhibition.
Letter to the Editor in reference to: Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.
Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.
Carcinoma, Ehrlich Tumor
Leukotriene-D4 induced cell shrinkage in Ehrlich ascites tumor cells.
Regulation of the cellular content of the organic osmolyte taurine in mammalian cells.
Carcinoma, Hepatocellular
15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
Nordihydroguaiaretic acid depletes ATP and inhibits a swelling-activated, ATP-sensitive taurine channel.
Carcinoma, Lewis Lung
Cyclooxygenase and lipoxygenase inhibitors as modulators of cancer therapies.
Enhanced endothelial cell retraction mediated by 12(S)-HETE: a proposed mechanism for the role of platelets in tumor cell metastasis.
Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.
Carcinoma, Merkel Cell
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Letter to the Editor in reference to: Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Carcinoma, Non-Small-Cell Lung
Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth.
Carcinoma, Renal Cell
Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma.
Carcinoma, Squamous Cell
Arachidonic acid metabolites in saliva of patients with squamous cell carcinoma of the head and neck.
Biosynthesis of prostaglandins and hydroxy fatty acids in primary squamous carcinomas of head and neck in humans.
Characterization and purification of a lipoxygenase inhibitor in human epidermoid carcinoma A431 cells.
Identification of a lipoxygenase inhibitor in A431 cells as a phospholipid hydroperoxide glutathione peroxidase.
Inhibition of head and neck tumor cell growth with arachidonic acid metabolism inhibition.
Lipoxygenase pathway of arachidonic acid metabolism in growth control of tumor cells of different type.
Carcinosarcoma
Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other polyunsaturated fatty acids.
Cardiotoxicity
Effects of cyclooxygenase and lipoxygenase inhibitors on digoxin-induced arrhythmias and haemodynamics in guinea-pigs.
The peroxidase activity of ADM-Fe(3+) cooperates with lipid peroxidation: The participation of hydroperoxide and hydroxyl radicals in the damage to proteins and DNA.
Cardiovascular Diseases
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease.
Role of lipoxygenase metabolites in cardiovascular disease.
Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry.
Central Nervous System Diseases
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Activity-Based Probes for 15-Lipoxygenase-1.
Choriocarcinoma
Effect of lipoxygenase products on choriogonadotropin secretion by cultured human choriocarcinoma JEG-3 cells pre- and post-stimulation with epidermal growth factor and a phorbol ester.
Chronic Periodontitis
Effect of Alox-15 Polymorphism on GCF Levels of Lipoxin-A4 in Chronic Periodontitis: A Preliminary Study.
Colitis
Effects of cyclooxygenase and lipoxygenase inhibition on eicosanoids and healing of acetic acid colitis in rats.
Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study.
Metabolism of arachidonic acid in acetic acid colitis in rats. Similarity to human inflammatory bowel disease.
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer.
Colitis, Ulcerative
Benoxaprofen in the treatment of active ulcerative colitis.
In vivo effects of orally administered prednisolone on prostaglandin and leucotriene production in ulcerative colitis.
In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis.
Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis.
Lipoxygenase metabolites of arachidonic acid do not induce mucus secretion from rabbit intestinal goblet cells in vitro.
Modulation of human colonic arachidonic acid metabolism by sulfasalazine.
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine.
[Synthesis of eicosanoids in the colonic mucosa in patients with ulcerative colitis]
Colitis-Associated Neoplasms
15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer.
Colonic Neoplasms
15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1? expression in human colon cancer cells.
Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.
Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
Cellular proliferation and lipid metabolism: importance of lipoxygenases in modulating epidermal growth factor-dependent mitogenesis.
Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells.
Cyclooxygenases and lipoxygenases in prostate and breast cancers.
Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers.
Effect of fish oil on levels of R- and S-enantiomers of 5-, 12-, and 15-hydroxyeicosatetraenoic acids in mouse colonic mucosa.
Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids.
Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues.
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer.
The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells.
Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer.
Therapeutic Molecular Targetingof 15-Lipoxygenase-1 in Colon Cancer.
Colorectal Neoplasms
15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma.
15-Lipoxygenase-1 expression suppresses the invasive properties of colorectal carcinoma cell lines HCT-116 and HT-29.
15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer.
15-lipoxygenase-1 in colorectal cancer: a review.
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
15-lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway.
15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1.
A GATA binding site is involved in the regulation of 15-lipoxygenase-1 expression in human colorectal carcinoma cell line, caco-2.
Arachidonic acid and colorectal carcinogenesis.
Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity.
Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells.
Expression of 15-lipoxygenase-1 in human colorectal cancer.
Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma.
GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells.
Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer.
Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention.
Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.
Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells.
The 15-lipoxygenase-1 expression may enhance the sensitivity to non-steroidal anti-inflammatory drug-induced apoptosis in colorectal cancers from patients who are treated with the compounds.
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
The methyltransferase inhibitor 5-aza-2-deoxycytidine induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer.
Common Variable Immunodeficiency
A novel arachidonic acid metabolite with stimulatory effect on PHA-induced mitogenesis of lymphocytes.
Improved in vitro antigen-specific antibody synthesis in two patients with common variable immunodeficiency taking an oral cyclooxygenase and lipoxygenase inhibitor (ketoprofen).
Confusion
Interaction between Mitochondrial Cytochromes and Linoleic Acid Hydroperoxide: POSSIBLE CONFUSION WITH LIPOXYGENASE AND ALTERNATIVE PATHWAY.
Conjunctivitis, Allergic
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Corneal Edema
Antagonists and inhibitors of lipid mediators in experimental inflammation of the cornea.
Corneal Injuries
Corneal reepithelialization and anti-inflammatory agents.
Increased synthesis of specific eicosanoids in rejected corneal grafts.
Corneal Neovascularization
Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat.
Coronary Artery Disease
Atherosclerosis: the eicosanoid connection.
Coronary Occlusion
Modulation of arachidonic acid metabolites and vulnerability to ventricular fibrillation during myocardial ischemia in the cat.
The effects of lipoxygenase inhibitor and peptidoleukotriene antagonist on myocardial injury in a canine coronary occlusion-reperfusion model.
The salvage of ischaemic myocardium by BW755C in anaesthetised dogs.
Cough
Pharmacological studies of allergic cough in the guinea pig.
Cowpox
Poxvirus-induced alteration of arachidonate metabolism.
Crohn Disease
In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis.
Regulated spatial distribution of cyclooxygenases and lipoxygenases in Crohn's ulcer.
Release of leukotriene B4 and 5-hydroxyeicosatetraenoic acid during phagocytosis of artificial immune complexes by peripheral neutrophils in chronic inflammatory bowel disease.
Cystic Fibrosis
Expression of cyclooxygenase and lipoxygenase enzymes in sinonasal mucosa of patients with cystic fibrosis.
Generation and metabolism of leukotrienes in granulocytes of patients with cystic fibrosis.
Deafness
Whole-exome sequencing identifies a novel missense variant within LOXHD1 causing rare hearing loss in a Chinese family.
Dehydration
Allene oxide synthases and allene oxides.
Jasmonic acid regulates ascorbate and glutathione metabolism in Agropyron cristatum leaves under water stress
Polyamines induce adaptive responses in water deficit stressed cucumber roots.
Salinity Effects on Guard Cell Proteome in Chenopodium quinoa.
Dementia
Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia.
Demyelinating Diseases
Leukotrienes and other lipoxygenase metabolites of arachidonic acid: their role in edema, ischemia and demyelination of the central nervous system.
Dental Pulp Calcification
Effect of olive stoning on the volatile and phenolic composition of virgin olive oil.
Dermatitis
Physiologic effects of columbinic acid and its metabolites on rat skin.
Superoxide anion in polymorphonuclear leukocytes of hairless rats suffering from magnesium-deficiency dermatitis.
The metabolic transformations of columbinic acid and the effect of topical application of the major metabolites on rat skin.
Dermatitis, Atopic
A double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid-based lipid infusion in atopic dermatitis.
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Lipoxygenase products of arachidonic acid in psoriasis, atopic dermatitis, and experimental arthritis.
Reduced lipoxygenase and cyclooxygenase mediated signaling in PBMC of atopic dermatitis patients.
[Essential fatty acids and the skin]
Dermatitis, Contact
Arachidonic acid metabolism in skin: experimental contact dermatitis in guinea pigs.
Dermatitis, Exfoliative
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
Diabetes Complications
Inhibitory effect of polar oregano extracts on aldose reductase and soybean lipoxygenase in vitro.
Diabetes Mellitus
Assessment of association between lipoxygenase genes variants in elderly Greek population and type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease.
Assessment of association between lipoxygenase genes variants in elderly Greek population and type 2 diabetes mellitus.
Effect of masoprocol on glucose transport and lipolysis by isolated rat adipocytes.
Eicosanoids, ?-cell function, and diabetes.
Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata).
Diabetic Nephropathies
Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice.
Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients.
Nordihydroguairetic acid, a lignin, prevents oxidative stress and the development of diabetic nephropathy in rats.
Oxidative stress and eicosanoids in the kidneys of hyperglycemic rats treated with dehydroepiandrosterone.
Roles of lipid mediators in kidney injury.
Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease.
Diabetic Neuropathies
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets.
Encephalomalacia
Lipoxygenase and other enzymes of arachidonic acid metabolism in the brain of chicks affected by nutritional encephalomalacia.
Encephalomyelitis
Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.
Encephalomyelitis, Autoimmune, Experimental
Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.
Endometrial Hyperplasia
The role of 15-lipoxygenase-1 expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas.
Endometriosis
Peritoneal fluid eicosanoids in chronic pelvic pain.
Endotoxemia
BW755C modifies endotoxin-induced respiratory failure in pigs.
Dexamethasone and indomethacin modify endotoxin-induced respiratory failure in pigs.
Endotoxemia in rats--influence of lipoxygenase blocker versus leukotriene receptor antagonist (BW755C vs LY171883).
Endotoxin-induced eicosanoid production by equine vascular endothelial cells and neutrophils.
Influence of steroidal and nonsteroidal anti-inflammatory agents on the accumulation of arachidonic acid metabolites in plasma and lung lymph after endotoxemia in awake sheep. Measurements of prostacyclin and thromboxane metabolites and 12-HETE.
Pulmonary dysfunction caused by diffuse lung inflammation. Roles of metabolites of arachidonic acid.
Pulmonary microvascular injury from lipoxygenase infusion: comparison with endotoxemia.
Enteritis
Unique regulation of Na-glutamine cotransporter SN2/SNAT5 in rabbit intestinal crypt cells during chronic enteritis.
Eosinophilia
Bradykinin induces eosinophil accumulation in the rat pleural cavity.
Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs.
Comparison of 5- and 15-lipoxygenase activities in blood and alveolar leukocyte preparations from normal subjects and patients with eosinophilia.
Experimental uterine eosinophilia in the rat. The role of some inhibitors of arachidonic acid metabolism.
Formation of oedema and accumulation of eosinophils in the guinea pig lung. Inhibition by inhaled beta-stimulants.
Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor.
Pharmacological modulation of lipopolysaccharide-induced pleural eosinophilia in the rat; a role for a newly generated protein.
Epilepsy
The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy.
Epiretinal Membrane
Detection of eicosanoids in epiretinal membranes of patients suffering from proliferative vitreoretinal diseases.
Erythema
Eicosapentaenoic acid as a modulator of inflammation. Effect on prostaglandin and leukotriene synthesis.
The pattern and kinetics in human skin of erythema and mediators during the acute and late-phase response (LPR).
Esophageal Neoplasms
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.
Esophagitis
Leukotrienes in acetylcholine-induced contraction of esophageal circular smooth muscle in experimental esophagitis.
Esophagitis, Peptic
Effect of Perilla frutescens Fixed Oil on Experimental Esophagitis in Albino Wistar Rats.
Essential Hypertension
Masoprocol lowers blood pressure in rats with fructose-induced hypertension.
Exanthema
Dermatosis in magnesium-deficient hairless rats: effects of steroidal and non-steroidal anti-inflammatory drugs.
Eye Burns
Chemical and thermal injuries of the eyes. Surgical and medical treatment based on clinical and pathophysiological findings.
Fibrosarcoma
Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells.
Inhibition of lipoxygenase pathway in macrophages co-cultivated with tumor cells.
Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo.
Fusariosis
Characterization of Fusarium wilt resistant somaclonal variants of banana cv. Rasthali by cDNA-RAPD.
Gastrointestinal Diseases
Review: lipoxygenase inhibitors and the gut.
Glaucoma
Betalain exerts a protective effect against glaucoma is majorly through the association of inflammatory cytokines.
Glioblastoma
Down-regulation of vinculin upon MK886-induced apoptosis in LN18 glioblastoma cells.
Influence of Lipoxygenase Inhibition on Glioblastoma Cell Biology.
mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.
Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells.
The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells.
Ultrastructural evidence for differentiation in a human glioblastoma cell line treated with inhibitors of eicosanoid metabolism.
[Effect of nordy on biological behaviors of malignant glioma cell line U87MG and the analysis of differential expression proteome]
Glioma
15-Lipoxygenase-1 induces lipid peroxidation and apoptosis, and improves survival in rat malignant glioma.
?-Conotoxins and ?-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells.
A novel lipoxygenase inhibitor Nordy attenuates malignant human glioma cell responses to chemotactic and growth stimulating factors.
Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12- lipoxygenase activation in glioma cells.
Augmentation of chemotherapy-triggered glioma cell apoptosis by blockade of arachidonic acid metabolism-the potential role of ceramide accumulation.
Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation.
Effective Combination Therapy for Malignant Glioma with TRAIL-Secreting Mesenchymal Stem Cells and Lipoxygenase Inhibitor MK886.
Effects of the 5-lipoxygenase inhibitors AA-863 and U-60,257 on human glioma cell lines.
Induction of Hsp68 by oxidative stress involves the lipoxygenase pathway in C6 rat glioma cells.
Interferon entry through the blood-brain barrier in glioma and its effect on lipoxygenase activity.
Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion.
Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP- and p38 MAPK-mediated up-regulation of death receptor 5 in malignant glioma.
Lipoxygenase inhibitors block CD95 ligand-mediated apoptosis of human malignant glioma cells.
mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.
Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells.
Preferential expression of chemokine receptor CXCR4 by highly malignant human gliomas and its association with poor patient survival.
[Nordy inhibits cell proliferation and angiogenic factor production of malignant human glioma cells mediated by formylpeptide receptor]
Glomerulonephritis
Glomerulonephritis: roles for lipoxygenase pathways in pathophysiology and therapy.
glutathione synthase deficiency
Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency.
Granuloma
Macrophage function in the Schistosoma mansoni egg-induced pulmonary granuloma. Role of arachidonic acid metabolites in macrophage Ia antigen expression.
Role of lipoxygenase products in murine pulmonary granuloma formation.
Substance P Upregulates LTB(4) in Rat Adherent Macrophages from Granuloma Induced by KMnO(4).
Granulomatous Disease, Chronic
Leukotriene biosynthesis by polymorphonuclear leukocytes from two patients with chronic granulomatous disease.
Graves Disease
Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines.
Hearing Loss
Bioconversion of Scutellaria baicalensis extract can increase recovery of auditory function in a mouse model of noise-induced hearing loss.
Whole-exome sequencing identifies a novel missense variant within LOXHD1 causing rare hearing loss in a Chinese family.
Heart Failure
Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice.
Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure.
Lipoxygenase inhibitor ML351 dysregulated an innate inflammatory response leading to impaired cardiac repair in acute heart failure.
Hepatitis
Review: lipoxygenase inhibitors and the gut.
Herpes Simplex
Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism.
Lipoxygenase-inhibitory action of antiviral polymeric oxidation products of polyphenols.
The effect of a new lipoxygenase inhibitor on the production of arachidonic acid metabolites during experimental herpes simplex keratitis.
Herpes Zoster
Role of arachidonic acid metabolism in ACTH-stimulated cortisol secretion by bovine adrenocortical cells.
Role of the lipoxygenase pathway in angiotensin II-mediated aldosterone biosynthesis in human adrenal glomerulosa cells.
Hidradenitis Suppurativa
Lipidomics Profiling of Hidradenitis Suppurativa Skin Lesions Reveals Lipoxygenase Pathway Dysregulation and Accumulation of Proinflammatory Leukotriene B4.
HIV Infections
Induction of 15-lipoxygenase-1 impairs expression of HIV-1 receptors CD4 and CXCR4 in monocytic cells.
Hodgkin Disease
Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils.
Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas.
Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line.
Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.
On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma.
Hydronephrosis
Eicosanoid synthesis by rabbit hydronephrotic cortical interstitial cells in culture.
Hyperalgesia
Acute thermal hyperalgesia in the rat is produced by activation of N-methyl-D-aspartate receptors and protein kinase C and production of nitric oxide.
Anti-inflammatory effect of licofelone against various inflammatory challenges.
Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.
Eicosapentaenoic acid as a modulator of inflammation. Effect on prostaglandin and leukotriene synthesis.
Hyperalgesic and edematogenic effects of Secapin-2, a peptide isolated from Africanized honeybee (Apis mellifera) venom.
Inflammatory mediators in the pronociceptive effects induced by Bothrops leucurus snake venom: The role of biogenic amines, nitric oxide, and eicosanoids.
Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance.
Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system.
Pharmacological evidence for a role of lipoxygenase products in platelet-activating factor (PAF)-induced hyperalgesia.
Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice.
The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivity.
Hypercholesterolemia
Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas.
Is there a role for 15-lipoxygenase in atherogenesis?
The role of peroxidases in the pathogenesis of atherosclerosis.
Hyperemia
Eicosanoid synthesis in human peritoneal macrophages stimulated with S. epidermidis.
Inhibitory effect of quinacrine on myocardial reactive hyperemia in the dog.
[Role of the endothelium in the development of reactive hyperemia]
[The participation of humoral factors released by the endothelium in the development of reactive hyperemia]
Hyperglycemia
Amelioration of streptozotocin-induced type 2 diabetes mellitus in Wistar rats by arachidonic acid.
Oxidative stress and eicosanoids in the kidneys of hyperglycemic rats treated with dehydroepiandrosterone.
The role of peroxidases in the pathogenesis of atherosclerosis.
Hyperinsulinism
Central interleukin 1-elicited hyperinsulinemia is mediated by prostaglandins but not autonomics.
Hypersensitivity
Abietic acid inhibits lipoxygenase activity.
Activation of a 15-lipoxygenase/leukotriene pathway in human polymorphonuclear leukocytes by the anti-inflammatory agent ibuprofen.
Helminth-induced intestinal inflammation.
Leukotrienes and lipoxygenase factors: mediators and modulators of the allergic reaction.
Lipoxygenase inhibitors as cancer chemopreventives: discovery, recent developments, and future perspectives.
New concepts in the pathogenesis of asthma.
Pharmacologic modulation of delayed-type hypersensitivity in mice.
Platelet hypersensitivity induced by 1-chloro-2, 4-dinitrobenzene, hydroperoxides and inhibition of lipoxygenase.
Role of lipoxygenase products in murine pulmonary granuloma formation.
The role of leukotrienes in allergen-induced late responses in allergic sheep.
[Blood platelets as one hemostatic indicator in patients with bronchial asthma]
[Effect of tolmetin on responsiveness of isolated guinea pig tracheal smooth muscles]
[New mediators of allergy and inflammation of a lipid nature]
Hypersensitivity, Delayed
Effects of cyclooxygenase and lipoxygenase inhibitors on inflammation associated with oxazolone-induced delayed hypersensitivity.
Hypersensitivity, Immediate
Can dietary selenium reduce leukotriene production?
Human respiratory mucus.
Prostaglandin-generating factor of anaphylaxis induces mucous glycoprotein release and the formation of lipoxygenase products of arachidonate from human airways.
Hypertension
12-Lipoxygenase products modulate calcium signals in vascular smooth muscle cells.
Biological properties of baicalein in cardiovascular system.
Functional significance of activation of calcium/calmodulin-dependent protein kinase II in angiotensin II--induced vascular hyperplasia and hypertension.
HETEs/EETs in renal glomerular and epithelial cell functions.
High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease.
Hypotensive effects of the lipoxygenase inhibitor phenidone in two-kidney, one clip Goldblatt hypertension.
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.
Inhibition of lipoxygenase pathway reduces blood pressure in renovascular hypertensive rats.
Lipoxygenase-dependent mechanisms in hypertension.
Masoprocol lowers blood pressure in rats with fructose-induced hypertension.
New insights into the pathophysiology of renovascular hypertension.
Pharmacological modulation of platelet activating factor (PAF)-induced bronchoconstriction and hypertension in anaesthetized guinea-pigs.
Regulation of 12-lipoxygenase by cytokines in vascular smooth muscle cells.
The Obligatory Role of the Acetylcholine-Induced Endothelium-Dependent Contraction in Hypertension: Can Arachidonic Acid Resolve this Inflammation?
The role of peroxidases in the pathogenesis of atherosclerosis.
Hypertension, Portal
Arachidonic acid metabolites and endothelial dysfunction of portal hypertension.
Hypertension, Pregnancy-Induced
Increased placental production of leukotriene B4 in gestational hypertension.
[The significance of eicosanoids in gestosis]
Hypertension, Pulmonary
Arachidonate raises vascular resistance but not permeability in lungs of awake sheep.
Chronic bronchitis: reflex on the pulmonary circulation.
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.
Lipoxygenase and cyclooxygenase blockade by BW755C does not prevent the secondary phase of septic pulmonary hypertension.
Prevention of endotoxin-induced pulmonary hypertension in primates by the use of a selective thromboxane synthetase inhibitor, OKY 1581.
Pulmonary hypertensive response to foreign body microemboli.
Hypertension, Renovascular
Hypotensive effects of the lipoxygenase inhibitor phenidone in two-kidney, one clip Goldblatt hypertension.
Renovascular hypertension.
Hypertriglyceridemia
High dietary fructose induces a hepatic stress response resulting in cholesterol and lipid dysregulation.
Hypoalbuminemia
The influence of albumin and calcium on human platelet arachidonic acid metabolism.
Hypotension
Lipoxygenase and cyclooxygenase blockade by BW755C prevents endotoxin-induced hypotension but not changes in glucose metabolism.
The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries (part 1): role of endothelium.
[The effect of indomethacin on the changes in the hemodynamics and coronary vascular resistance during anaphylactic shock]
Ichthyosiform Erythroderma, Congenital
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
Ichthyosis
Aloxe3 Knockout Mice Reveal a Function of Epidermal Lipoxygenase-3 as Hepoxilin Synthase and Its Pivotal Role in Barrier Formation.
An update on molecular aspects of the non-syndromic ichthyoses.
Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha.
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.
Report of a Novel ALOX12B Mutation in Self-Improving Collodion Ichthyosis with an Overview of the Genetic Background of the Collodion Baby Phenotype.
Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support A Specific Role in Lipid-Protein Crosslinking.
Updated molecular genetics and pathogenesis of ichthiyoses.
Ichthyosis, Lamellar
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Infarction, Middle Cerebral Artery
Arachidonic acid metabolite production following focal cerebral ischemia: time course and effect of meclofenamate.
Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia.
Infections
?-Carrageenan Suppresses Tomato Chlorotic Dwarf Viroid (TCDVd) Replication and Symptom Expression in Tomatoes.
A 13-Lipoxygenase, GhLOX2, positively regulates cotton tolerance against Verticillium dahliae through JA-mediated pathway.
A leaf lipoxygenase of potato induced specifically by pathogen infection.
A Lipoxygenase Pathway Is Activated in Rice after Infection with the Rice Blast Fungus Magnaporthe grisea.
A novel lipoxygenase from rice. Primary structure and specific expression upon incompatible infection with rice blast fungus.
A novel plastidial lipoxygenase of maize (Zea mays) ZmLOX6 encodes for a fatty acid hydroperoxide lyase and is uniquely regulated by phytohormones and pathogen infection.
Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor.
Arachidonic Acid Derived Lipid Mediators Influence Kaposi's Sarcoma-Associated Herpesvirus Infection and Pathogenesis.
Arachidonic acid metabolism by murine peritoneal macrophages infected with Leishmania donovani: in vitro evidence for parasite-induced alterations in cyclooxygenase and lipoxygenase pathways.
Characterization of a novel resistance-related deoxycytidine deaminase from Brassica oleracea var. capitata.
Cryogenic induced ocular HSV-1 reactivation is enhanced by an inhibitor of the lipoxygenase pathway.
Differential formation of octadecadienoic acid and octadecatrienoic acid products in control and injured/infected potato tubers.
Differential modulation of the lipoxygenase cascade during typical and latent Pectobacterium atrosepticum infections.
Duplicate maize 13-lipoxygenase genes are differentially regulated by circadian rhythm, cold stress, wounding, pathogen infection, and hormonal treatments.
Effect of tebuconazole and trifloxystrobin on Ceratocystis fimbriata to control black rot of sweet potato: processes of reactive oxygen species generation and antioxidant defense responses.
Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts.
Effects of enhanced UV-B radiation on the interaction between rice and Magnaporthe oryzae in Yuanyang terrace.
Enhancement by parainfluenza 3 infection of contractile responses to substance P and capsaicin in airway smooth muscle from the guinea pig.
Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model.
Exogenous application of methyl jasmonate induces defense response and develops tolerance against mungbean yellow mosaic India virus in Vigna mungo.
Green leaf volatiles and jasmonic acid enhance susceptibility to anthracnose diseases caused by Colletotrichum graminicola in maize.
Hormonal seed-priming improves tomato resistance against broomrape infection.
Hydrophobic proteins secreted into the apoplast may contribute to resistance against Phytophthora infestans in potato.
Identification of lipoxygenase (LOX) genes from legumes and their responses in wild type and cultivated peanut upon Aspergillus flavus infection.
Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism.
Inhibitory effects of sulfated lentinan with different degree of sulfation against tobacco mosaic virus (TMV) in tobacco seedlings.
Involvement of epicatechin in the regulation of lipoxygenase activity during activation of quiescent Colletotrichum gloeosporioides infections of ripening avocado fruits.
Leaf rust induced volatile organic compounds signalling in willow during the infection.
Lipid profiling of the Arabidopsis hypersensitive response reveals specific lipid peroxidation and fragmentation processes: biogenesis of pimelic and azelaic Acid.
Lipoxygenase activity associated to isolated soybean plasma membranes.
Lipoxygenase Activity Increment in Infected Tomato Leaves and Oxidation Product of Linolenic Acid by Its In Vitro Enzyme Reaction.
Lipoxygenase gene expression in the tobacco-Phytophthora parasitica nicotianae interaction.
Lipoxygenase metabolites of alpha-linolenic acid in the development of resistance in pigeonpea, Cajanus cajan (L.) Millsp, seedlings against Fusarium udum infection.
Long-term protection against tobacco mosaic virus induced by the marine alga oligo-sulphated-galactan Poly-Ga in tobacco plants.
Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis.
Oak gall wasp infections of Quercus robur leaves lead to profound modifications in foliage photosynthetic and volatile emission characteristics.
Oak powdery mildew (Erysiphe alphitoides)-induced volatile emissions scale with the degree of infection in Quercus robur.
Overexpression of Camellia sinensis Thaumatin-Like Protein, CsTLP in Potato Confers Enhanced Resistance to Macrophomina phaseolina and Phytophthora infestans Infection.
Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors.
Oxylipin biosynthesis genes positively regulate PCD during compatible infections by the synergistic pair Potato virus X-Potato virus Y and by Tomato spotted wilt virus.
Polyamine metabolism and lipoxygenase activity during Fusarium oxysporum f. sp. ricini -Castor interaction.
Poxvirus-induced alteration of arachidonate metabolism.
Proteomics analysis reveals novel host molecular mechanisms associated with thermotherapy of 'Ca. Liberibacter asiaticus'-infected citrus plants.
Pseudomonas aeruginosa Lipoxygenase LoxA Contributes to Lung Infection by Altering the Host Immune Lipid Signaling.
Purification and properties of lipoxygenase induced in downy mildew resistant pearl millet seedlings due to infection with Sclerospora graminicola.
Role of pathogen-induced volatiles in the Nicotiana tabacum-Golovinomyces cichoracearum interaction.
Seed-Derived Ethylene Facilitates Colonization but Not Aflatoxin Production by Aspergillus flavus in Maize.
Serial Metabolome Changes in a Prospective Cohort of Subjects with Influenza Viral Infection and Comparison with Dengue Fever.
Silicon induced systemic defense responses in perennial ryegrass against infection by Magnaporthe oryzae.
Synchronised regulation of disease resistance in primed finger millet plants against the blast disease.
The effect of a new lipoxygenase inhibitor on the production of arachidonic acid metabolites during experimental herpes simplex keratitis.
Time-course of lipoxygenase, antioxidant enzyme activities and H?O? accumulation during the early stages of Rhizobium-legume symbiosis
Trichoderma harzianum ETS 323-mediated resistance in Brassica oleracea var. capitata to Rhizoctonia solani involves the novel expression of a glutathione S-transferase and a deoxycytidine deaminase.
Wounding and pathogen infection induce a chloroplast-targeted lipoxygenase in the common bean (Phaseolus vulgaris L.).
[Biochemical aspects of the interaction of the malarial parasite, Plasmodium berghei, with erythrocytes of the host]
[Effect of influenza virus infection on arachidonic acid cascade in mouse thrombocytes]
Infertility, Male
Cytoplasmic Male Sterility in Barley : VIII. LIPOXYGENASE ACTIVITY AND ANTHER AMINO NITROGEN IN THE msm1-Rfm1a SYSTEM.
Inflammatory Bowel Diseases
Benoxaprofen in the treatment of active ulcerative colitis.
Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.
Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study.
Human colonic (Na+ + K+)-ATPase and specific ouabain binding are not influenced by lipoxygenase products or superoxide radicals.
Inhibition of LOX by flavonoids: a structure-activity relationship study.
Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro.
Metabolism of arachidonic acid in acetic acid colitis in rats. Similarity to human inflammatory bowel disease.
New developments in the pharmacotherapy of inflammatory bowel disease.
Release of leukotriene B4 and 5-hydroxyeicosatetraenoic acid during phagocytosis of artificial immune complexes by peripheral neutrophils in chronic inflammatory bowel disease.
Source of endogenous arachidonate and 5-lipoxygenase products in human neutrophils stimulated by bradykinin and A23187.
The role of 12-lipoxygenase in pancreatic -cells (Review).
Insulin Resistance
Baicalein protects against hypertension associated with diabetes: effect on vascular reactivity and stiffness.
Protectin DX ameliorates hepatic steatosis by suppression of endoplasmic reticulum stress via AMPK-induced ORP150 expression.
Protectin DX ameliorates palmitate- or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPAR?-dependent pathway in mice.
Insulinoma
Hepoxilin A(3) protects ?-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid.
Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus.
Intellectual Disability
Linking the Fragile X mental retardation protein to the lipoxygenase pathway.
Ischemic Attack, Transient
Development of cyclooxygenase and lipoxygenase metabolites of arachidonic acid after transient cerebral ischemia.
Joint Diseases
An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model.
Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.
Modulation of arachidonic acid metabolism in experimental arthritis induced by Salmonella enteritidis. I. Effect of ibuprofen and flurbiprofen on experimental arthritis induced by Salmonella enteritidis.
[Levels of different metabolites of arachidonic acid in synovial fluid of patients with arthrosis or rheumatoid arthritis]
Keratitis
Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis.
Modulation of immunogenic keratitis in rabbits by topical administration of inhibitors of lipoxygenase and cyclooxygenase.
Regulation of lipoxygenase-1 and Dectin-1 on interleukin-10 in mouse Aspergillus fumigatus keratitis.
The effect of a new lipoxygenase inhibitor on the production of arachidonic acid metabolites during experimental herpes simplex keratitis.
Treatment of experimental Pseudomonas keratitis with cyclo-oxygenase and lipoxygenase inhibitors.
Keratitis, Herpetic
The effect of a new lipoxygenase inhibitor on the production of arachidonic acid metabolites during experimental herpes simplex keratitis.
Kidney Diseases
HETEs/EETs in renal glomerular and epithelial cell functions.
Leukemia
Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae).
Antiproliferative effects of lipoxygenase inhibitors on human leukemia cells.
Antiproliferative effects of lipoxygenase inhibitors on malignant human hematopoietic cell lines.
Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.
Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia.
Effect of the 5-hydroperoxide of eicosatetraenoic acid and inhibitors of the lipoxygenase pathway on the formation of slow reacting substance by rat basophilic leukemia cells; direct evidence that slow reacting substance is a product of the lipoxygenase pathway.
Effects of lipoxygenase and glutathione pathway inhibitors on leukemic cell line growth.
Evidence that endogenous generation of leukotrienes does not regulate proliferation of malignant hemopoietic cell lines.
Inhibitors of lipoxygenase metabolism exert synergistic effects with retinoic acid on differentiation of human leukemia HL-60 cells.
Metabolism of cyclooxygenase and lipoxygenase products by 15-prostaglandin dehydrogenase from human HL-60 leukemia cells.
Optimization of cofactors which regulate RBL-1 arachidonate 5-lipoxygenase.
Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro.
Selective inhibition of the lipoxygenase metabolic pathway of arachidonic acid by the SRS-A antagonist, FPL 55712.
Leukemia P388
Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells.
Leukemia, Erythroblastic, Acute
15-Lipoxygenase products of arachidonate play a role in proliferation of transformed erythroid cells.
Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells.
Changes in lipoxygenase activities in human erythroleukemia (HEL) cells during diosgenin-induced differentiation.
Comparison of the effect of lipoxygenase metabolites of arachidonic acid and eicosapentaenoic acid on human natural killer cell cytotoxicity.
Lipoxygenase activity in altered gravity.
Lipoxygenase products induce ultraweak light emission from human erythroleukemia cells.
Ribozyme-mediated suppression of platelet type 12 lipoxygenase in human erythroleukemia cells.
Leukemia, Lymphoid
Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis.
Leukotriene production by fresh human bone marrow cells: evidence of altered lipoxygenase activity in chronic myelocytic leukemia.
Lipoxygenase products in myeloproliferative disorders: increased leukotriene C4 and decreased lipoxin formation in chronic myeloid leukemia.
Platelet and leukocyte lipoxygenase products in a patient with chronic granulocytic leukemia undergoing syngeneic bone marrow transplantation.
Leukemia, Myeloid
Antiproliferative effects of lipoxygenase inhibitors on malignant human hematopoietic cell lines.
Leukemia, T-Cell
Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis.
Leukopenia
Differential protective activities of site specific lipoxygenase inhibitors in endotoxic shock and production of tumor necrosis factor.
Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade.
linoleate 13s-lipoxygenase deficiency
Acquired von Willebrand disease and storage pool disease in chronic myelocytic leukemia.
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Deficiency of platelet lipoxygenase activity in myeloproliferative disorders.
Lipoxygenase deficiency in primary thrombocythemia is not a true deficiency.
Platelet lipoxygenase deficiency.
Primary thrombocythaemia in childhood: symptomatic episodes and their relationship to thromboxane A2, 6-keto-PGE1 and 12-hydroxy-eicosatetraenoic acid production: a case report.
Lipidoses
[Effects of modifications of lipoproteins by water soluble forms of lineoleic-hydroxamic acid on biochemical markers of development of atherosclerosis]
Liver Cirrhosis
Reduction of apparent indicators of liver cirrhosis in rats by the arachidonate lipoxygenase inhibitor BW755C.
Synthesis of eicosanoids by circulating mononuclears in healthy people and in patients with liver cirrhosis.
Lung Diseases
A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1.
Activity-Based Probes for 15-Lipoxygenase-1.
Identification of leukotrienes in the sputum of patients with cystic fibrosis.
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
Lung Injury
Effects of ONO-1078, a peptide leukotriene antagonist, on endotoxin-induced acute lung injury.
Eicosanoids are involved in the permeability changes but not the pulmonary hypertension after systemic activation of complement.
Endotoxin-induced lung injury in rats: role of eicosanoids.
Increases in severity of lung damage and mortality by treatment with cyclo and lipoxygenase inhibitors in bleomycin and hyperoxia model of lung injury in hamsters.
Influence of cyclooxygenase and lipoxygenase inhibitors on oxidative stress-induced lung injury.
Inhibition of eicosanoids does not prevent neutrophil injury from phorbol in isolated rabbit lung.
Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor.
Leukotriene inhibitors attenuate rat lung injury induced by hydrogen peroxide.
Phospholipase A2-induced lung edema and its mechanism in isolated perfused guinea pig lung.
The early involvement of pulmonary prostaglandins in hyperoxic lung injury.
The role of cyclooxygenase and lipoxygenase mediators in oxidant-induced lung injury.
Vasoactive intestinal peptide and helodermin inhibit phospholipase A2 activity in vitro.
Lung Neoplasms
Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth.
Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines.
Lymphatic Metastasis
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Lymphoma
Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae).
Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas.
Glucocorticoid-induced lymphoma cell growth inhibition: the role of leukotriene B4.
Modulation of cellular proliferation and induction of apoptosis in a human lymphoma cell line after treatment with selective lipoxygenase inhibitors.
Lymphoma, Non-Hodgkin
Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.
Mastitis
The combined use of lipoxygenase and cyclooxygenase inhibitors in Klebsiella pneumoniae-induced bovine mastitis.
Mastocytoma
Effects of a novel fatty acid derivative [(7E)-8-(2-naphthyl)-5,6-trans-5,6-methano-7-octenoic acid] on arachidonic acid metabolism in cultured cells.
Inhibition of leukotriene C and leukotriene D biosynthesis.
Inhibitors of lipoxygenase have antiproliferative effects on P815 murine mastocytoma cells.
Mast cells and cell-to-cell interactions in airways.
Schistosoma mansoni: cercarial eicosanoid production and penetration response inhibited by esculetin and ibuprofen.
Tetraene and pentaene leukotrienes: selective production from murine mastocytoma cells after dietary manipulation.
Melanoma
Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids.
Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells.
In Vitro Effects of Selective COX and LOX Inhibitors and Their Combinations with Antineoplastic Drugs in the Mouse Melanoma Cell Line B16F10.
Inhibition of lipoxygenase pathway in macrophages co-cultivated with tumor cells.
Regulation of melanoma-cell motility by the lipoxygenase metabolite 12-(S)-HETE.
The lipoxygenase metabolite 12(S)-HETE induces a cytoskeleton-dependent increase in surface expression of integrin alpha IIb beta 3 on melanoma cells.
Melanoma, Amelanotic
Melanoma cell spreading on fibronectin induced by 12(S)-HETE involves both protein kinase C- and protein tyrosine kinase-dependent focal adhesion formation and tyrosine phosphorylation of focal adhesion kinase (pp125FAK).
Role of protein kinase C and phosphatases in 12(S)-HETE-induced tumor cell cytoskeletal reorganization.
Melanoma, Experimental
Inhibition of lipoxygenase pathway in macrophages co-cultivated with tumor cells.
Inhibition of radiation-enhanced expression of integrin and metastatic potential in B16 melanoma cells by a lipoxygenase inhibitor.
Mesothelioma
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Metabolic Diseases
Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research.
Miosis
Intraocular effects of lipoxygenase pathway products in arachidonic acid metabolism.
Mite Infestations
Study of defense-related gene expression in grapevine infested by Colomerus vitis (Acari: Eriophyidae).
Mouth Neoplasms
Lipoxygenase products in human saliva: patients with oral cancer compared to controls.
The cyclo-oxygenase and lipoxygenase pathways in human oral cancer tissue.
Multiple Sclerosis
Effect of calcium ionophore A23187 and of leukotrienes B4 and C4 on the adherence of mononuclear leucocytes in multiple sclerosis.
Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis.
Measles virus-induced mononuclear leukocyte adherence inhibition: effect of some drugs influencing arachidonic acid metabolic pathways.
Myeloproliferative Disorders
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Deficiency of platelet lipoxygenase activity in myeloproliferative disorders.
Deficient induction of leukotriene synthesis in human neutrophils by lipoxygenase-deficient platelets.
Lipoxygenase products in myeloproliferative disorders: increased leukotriene C4 and decreased lipoxin formation in chronic myeloid leukemia.
Primary thrombocythaemia in childhood: symptomatic episodes and their relationship to thromboxane A2, 6-keto-PGE1 and 12-hydroxy-eicosatetraenoic acid production: a case report.
Myocardial Infarction
Altered lipoxygenase metabolites and leukocyte involvement in an acute occlusion-reperfusion model of canine myocardial infarction.
Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation.
Platelet lipoxygenase defect (Wien-Penzing defect) in two patients with myocardial infarction.
Protective effects of a thromboxane synthetase inhibitor, a thromboxane antagonist, a lipoxygenase inhibitor and a leukotriene C4, D4 antagonist on myocardial injury caused by acute myocardial infarction in the canine heart.
Myocardial Ischemia
Effects of BW755C, a mixed cyclo-oxygenase-lipoxygenase inhibitor, following traumatic spinal cord injury in rats.
Protective actions of propyl gallate, a lipoxygenase inhibitor, on the ischemic myocardium.
Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.
The Arachidonate 15-Lipoxygenase Enzyme Product 15-HETE Is Present in Heart Tissue from Patients with Ischemic Heart Disease and Enhances Clot Formation.
Myocardial Reperfusion Injury
Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function. Implications for pathogenesis of myocardial reperfusion injury.
Effects of supplementation with iloprost on the cardioprotection by BW755C (a dual inhibitor of cyclooxygenase and lipoxygenase enzymes) in myocardial reperfusion injury.
Myocarditis
Antiinflammatory effect of a lipoxygenase inhibitor (FLM 5011) in severe active myocarditis.
Nasal Obstruction
Mechanisms of aspirin sensitivity.
Nasal Polyps
Changes in urinary LTE4 and nasal functions following nasal provocation test with ASA in ASA-tolerant and -intolerant asthmatics.
Cyclooxygenase and lipoxygenase metabolite generation in nasal polyps.
Eicosanoids from biopsy of normal and polypous nasal mucosa.
Expression of cyclooxygenase and lipoxygenase enzymes in nasal polyps of aspirin-sensitive and aspirin-tolerant patients.
Urinary LTE4 is higher after nasal provocation test with L-ASA in bronchial than in only nasal responders.
Neoplasm Metastasis
12(S)-hydroxyeicosatetraenoic acid increases the actin microfilament content in B16a melanoma cells: a protein kinase-dependent process.
12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.
15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary.
Arachidonic acid metabolism.
Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor.
Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse.
Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line.
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Inhibition of radiation-enhanced expression of integrin and metastatic potential in B16 melanoma cells by a lipoxygenase inhibitor.
Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer.
Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis.
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Lipoxygenase metabolites and cancer metastasis.
Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C.
Lipoxygenase regulation of membrane expression of tumor cell glycoproteins and subsequent metastasis.
Lipoxygenase-5 is overexpressed in prostate adenocarcinoma.
Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase.
Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma.
Oncogenic action of phospholipase A2 in prostate cancer.
Oncogenic action of secreted phospholipase A2 in prostate cancer.
The effect of 15-lipoxygenase-1 expression on cancer cells.
Tumor cell-endothelial cell interactions: evidence for roles for lipoxygenase products of arachidonic acid in metastasis.
Neoplasms
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha.
12(S)-HETE, pleiotropic functions, multiple signaling pathways.
12(S)-hydroxyeicosatetraenoic acid increases the actin microfilament content in B16a melanoma cells: a protein kinase-dependent process.
13-Hydroxyoctadecadienoic acid is the mitogenic signal for linoleic acid-dependent growth in rat hepatoma 7288CTC in vivo.
15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size).
15-Lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.
15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma.
15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells.
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
15-lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway.
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary.
15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1? expression in human colon cancer cells.
15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells.
4 Beta- and 4 alpha-12-O-tetradecanoylphorbol-13-acetate elicit arachidonate release from epidermal cells through different mechanisms.
5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.
7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition.
?-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer.
Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo.
Activity of the lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone) and derivatives on the inhibition of adhesion molecule expression on human umbilical vascular endothelial cells.
Anti-inflammatory effects and antioxidant activity of dihydroasparagusic acid in lipopolysaccharide-activated microglial cells.
Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae).
Anti-proliferative effects of lichen-derived lipoxygenase inhibitors on twelve human cancer cell lines of different tissue origin in vitro.
Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs.
Antitumor effects of inhibitors of arachidonic acid cascade on experimentally induced intestinal tumors.
Arachidonate has protumor-promoting action that is inhibited by linoleate in mouse skin carcinogenesis.
Arachidonic acid and colorectal carcinogenesis.
Arachidonic acid metabolism in growth control of A549 human lung adenocarcinoma cells.
Arachidonic acid metabolism.
Arachidonic acid metabolites in cutaneous carcinomas. Evidence suggesting that elevated levels of prostaglandins in basal cell carcinomas are associated with an aggressive growth pattern.
Arachidonic acid metabolites in saliva of patients with squamous cell carcinoma of the head and neck.
Arachidonic acid potentiates superoxide anion radical production by murine peritoneal macrophages stimulated with tumor promoters.
Attenuation of atherosclerotic complications by modulating inflammatory responses in hypercholesterolemic rats with dietary Njavara rice bran oil.
Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid.
Binding of 13-HODE and 5-, 12- and 15-HETE to endothelial cells and subsequent platelet, neutrophil and tumor cell adhesion.
Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia.
Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by B16 amelanotic melanoma cells is a determinant of their metastatic potential.
Breaking the cycle: the role of omega-3 polyunsaturated fatty acids in inflammation-driven cancers.
Cancer immunotherapy: potential involvement of mediators.
Cancer: Lipoxygenase makes a leaky tumour.
Cell killing and induction of manganous superoxide dismutase by tumor necrosis factor-alpha is mediated by lipoxygenase metabolites of arachidonic acid.
Characterization of integrin expression and regulation on SW-480 human colon adenocarcinoma cells and the effect of rhodostomin on basal and upregulated tumor cell adhesion.
Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice.
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.
Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate.
Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.
Comparative effect of horse gram and black gram on inflammatory mediators and antioxidant status.
Comparison of the effects of ketoprofen and flunixin meglumine on the in vitro response of equine peripheral blood monocytes to bacterial endotoxin.
Comparison of the gene expression profiles of resistant and non-resistant Japanese black pine inoculated with pine wood nematode using a modified LongSAGE technique
Computational and pharmacological investigation of novel 1,5-diaryl-1,4-pentadien-3-one derivatives for analgesic, anti-inflammatory and anticancer potential.
Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.
Conjugated linoleic acid reduction of murine mammary tumor cell growth through 5-hydroxyeicosatetraenoic acid.
COX and LOX eicosanoids modulate platelet activation and procoagulation induced by two murine cancer cells.
Curcumin impairs tumor suppressor p53 function in colon cancer cells.
Cyclooxygenase and lipoxygenase inhibitors as modulators of cancer therapies.
Cyclooxygenase and lipoxygenase inhibitors in cancer therapy.
Cyclooxygenase, lipoxygenase and tumor angiogenesis.
Cyclooxygenases and lipoxygenases in prostate and breast cancers.
Cytotoxic and apoptotic functions of licofelone on rat glioma cells.
Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents.
Development of novel peptide inhibitor of Lipoxygenase based on biochemical and BIAcore evidences.
Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor.
Differential protective activities of site specific lipoxygenase inhibitors in endotoxic shock and production of tumor necrosis factor.
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation.
Docking Studies and Molecular Dynamics Simulation of Ipomoea batatas L. Leaves Compounds as Lipoxygenase (LOX) Inhibitor.
Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation.
Drugs that target lipoxygenases and leukotrienes as emerging therapies for asthma and cancer.
Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells.
Effect of ?-3 and ?-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model.
Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.
Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse.
Effects of arachidonic acid metabolites in a murine model of squamous cell carcinoma.
Effects of endothelial cell treatment on 13-HODE and prostacyclin synthesis and its correlation with tumor cell-vascular endothelial cell adhesion.
Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds.
Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice.
Effects of systemic complement activation and neutrophil-mediated pulmonary injury on the retention and metastasis of circulating cancer cells in mouse lungs.
Effects of various inhibitors of arachidonic acid oxygenation on macrophage superoxide release and tumoricidal activity.
Efficacy of a Standardized Turmeric Extract Comprised of 70% Bisdemothoxy-Curcumin (REVERC3) Against LPS-Induced Inflammation in RAW264.7 Cells and Carrageenan-Induced Paw Edema.
Eicosanoid 12(S)-HETE activates phosphatidylinositol 3-kinase.
Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha.
Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment.
Eicosanoid synthesis by alveolar macrophages in rats with malignant mammary tumors: differences in rats treated with and without carrageenan implants.
Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line.
Eicosanoids in inflammation and cancer: the role of COX-2.
Endogenous lipoxygenase metabolites mediate A23187 induced macrophage cytostasis towards P815 tumor cells in vitro.
Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression.
Enhanced endothelial cell retraction mediated by 12(S)-HETE: a proposed mechanism for the role of platelets in tumor cell metastasis.
Enhanced tumor cell adhesion to the subendothelial matrix resulting from 12(S)-HETE-induced endothelial cell retraction.
Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate.
Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors.
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Expression profile of NF-?B regulated genes in sporadic colorectal cancer patients.
Fatty acid metabolites in rapidly proliferating breast cancer.
Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse.
Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies.
Generation of leukotrienes and hydroxyeicosatetraenoic acids in peritoneal macrophages of tumor-bearing mice.
Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.
Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis.
Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.
Human 5-, 12- and 15-lipoxygenase-1 coexist in kidney but show opposite trends and their balance changes in cancer.
Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.
Impact of polyphenols in phagocyte functions.
Impairment of testicular function in electronic cigarette (e-cig, e-cigs) exposed rats under low-voltage and nicotine-free conditions.
In Silico Screening for Anti-Inflammatory Bioactive Molecules from Ayurvedic Decoction, Balaguluchyadi Kashayam.
Increased invasion of malignant gliomas after 15-LO-1 and HSV-tk/ganciclovir combination gene therapy.
Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is enhanced by endogenous metabolites of lipoxygenase and counteracted by prostaglandin E2.
Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is inhibited by both prostaglandin E2 and nordihydroguaiaretic acid, a lipoxygenase inhibitor.
Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1.
Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked.
Influence of Lipoxygenase Inhibition on Glioblastoma Cell Biology.
Influence of maternal diet enrichment with conjugated linoleic acids on lipoxygenase metabolites of polyunsaturated fatty acids in serum of their offspring with 7,12-dimethylbenz[a]anthracene induced mammary tumors.
Inhibition by lipoxygenase inhibitors of 7-bromomethylbenz[a]anthracene-caused epidermal ornithine decarboxylase induction and skin tumor promotion in mice.
Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion by nordihydroguaiaretic acid, a lipoxygenase inhibitor, and p-bromophenacyl bromide, a phospholipase A2 inhibitor.
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea.
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway.
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition.
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects.
Inhibition of human malignant neuroblastoma cell DNA synthesis by lipoxygenase metabolites of arachidonic acid.
Inhibition of lipoxygenase pathway in macrophages co-cultivated with tumor cells.
Inhibition of LOX by flavonoids: a structure-activity relationship study.
Inhibition of lung tumorigenesis by NSAIDS: a working hypothesis.
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
Inhibition of radiation-enhanced expression of integrin and metastatic potential in B16 melanoma cells by a lipoxygenase inhibitor.
Inhibition of soybean lipoxygenase and mouse skin tumor promotion by onion and garlic components.
Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis.
Inhibition of TPA and 12(S)-HETE-stimulated tumor cell adhesion by prostacyclin and its stable analogs: rationale for their antimetastatic effects.
Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome.
Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid.
Inhibition of tumour growth by lipoxygenase inhibitors.
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin.
Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.
Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta.
Intracellular Ca2+ mediates lipoxygenase-induced proliferation of U-373 MG human astrocytoma cells.
Intravitreal adenoviral 15-lipoxygenase-1 gene transfer prevents vascular endothelial growth factor A induced neovascularization in rabbit eyes.
Involvement of 15-lipoxygenase-1 in the regulation of breast cancer cell death induced by sodium butyrate.
Involvement of 5-lipoxygenase in programmed cell death of cancer cells.
Involvement of inflammatory mediators in macrophage antitumor activity.
Jasonia glutinosa (L.) DC., a traditional herbal medicine, reduces inflammation, oxidative stress and protects the intestinal barrier in a murine model of colitis.
Ketoconazole attenuates radiation-induction of tumor necrosis factor.
Lentinan augments skin reaction induced by bradykinin: its correlation with vascular dilatation and hemorrhage responses and antitumor activities.
Leukotriene-D4 induced cell shrinkage in Ehrlich ascites tumor cells.
Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis.
Lipoxygenase (LOX) Pathway: A Promising Target to Combat Cancer.
Lipoxygenase in Human Tumor Cells.
Lipoxygenase inhibitors as cancer chemopreventives: discovery, recent developments, and future perspectives.
Lipoxygenase inhibitors as potential cancer chemopreventives.
Lipoxygenase inhibitors but not site specific 5-lipoxygenase blockers protect against endotoxic shock and inhibit production of tumor necrosis factor.
Lipoxygenase inhibitors enhance tumor suppressive effects of jun proteins on v-myb-transformed monoblasts BM2.
Lipoxygenase inhibitors for cancer prevention: promises and risks.
Lipoxygenase inhibitors induce arrest of tumor cells in S-phase of the cell cycle.
Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis.
Lipoxygenase inhibitors prevent urological cancer cell growth.
Lipoxygenase inhibitors suppress formation of tumor necrosis factor in vitro and in vivo.
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Lipoxygenase metabolism: roles in tumor progression and survival.
Lipoxygenase metabolites and cancer metastasis.
Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C.
Lipoxygenase pathway of arachidonic acid metabolism in growth control of tumor cells of different type.
Lipoxygenase products regulate IRGpIIb/IIIa receptor mediated adhesion of tumor cells to endothelial cells, subendothelial matrix and fibronectin.
Lipoxygenase regulation of membrane expression of tumor cell glycoproteins and subsequent metastasis.
Lipoxygenase-5 is overexpressed in prostate adenocarcinoma.
Lung cancer cell lines inhibit leukotriene B4 production by human polymorphonuclear leukocytes at the level of phospholipase A2.
Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504).
Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells.
Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion.
Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway.
MK886-induced apoptosis depends on the 5-LO expression level in human malignant glioma cells.
Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase.
Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma.
Morusinol extracted from Morus alba inhibits arterial thrombosis and modulates platelet activation for the treatment of cardiovascular disease.
mPGES-1 and ALOX5/-15 in tumor-associated macrophages.
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro.
Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer.
Nafazatrom (Bay g 6575) inhibition of tumor cell lipoxygenase activity and cellular proliferation.
Natural Products as Anticancerous Therapeutic Molecules with Special Reference to Enzymatic Targets Topoisomerase, COX, LOX and Aromatase.
Neoplasms escape selective COX-2 inhibition in an animal model of breast cancer.
New actions of melatonin on tumor metabolism and growth.
Nordihydroguaiaretic acid suppression of rat mammary carcinogenesis induced by N-methyl-N-nitrosourea.
Nutritional and botanical modulation of the inflammatory cascade--eicosanoids, cyclooxygenases, and lipoxygenases--as an adjunct in cancer therapy.
Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase.
Oncogenic action of phospholipase A2 in prostate cancer.
Oncogenic action of secreted phospholipase A2 in prostate cancer.
Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.
Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition.
Phytochemistry and pharmacology of Ferula persica Boiss.: A review.
Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells.
Platelet-activating factor (PAF) enhances tumor necrosis factor production by alveolar macrophages. Prevention by PAF receptor antagonists and lipoxygenase inhibitors.
Potential use of lipoxygenase inhibitors for cancer chemoprevention.
Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin.
Products of arachidonic acid metabolism and the effects of cyclooxygenase inhibition on ongoing cutaneous allergic reactions in human beings.
Prostaglandin production by murine tumors as a predictor for therapeutic response to indomethacin.
Prostate cancer vs hyperplasia: relationships with prostatic and adipose tissue fatty acid composition.
Prostate Tumor Growth and Recurrence Can Be Modulated by the omega-6:omega-3 Ratio in Diet: Athymic Mouse Xenograft Model Simulating Radical Prostatectomy.
Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes.
Protective Effect of Ginkgolic Acid in Attenuating LDL Induced Inflammation Human Peripheral Blood Mononuclear Cells via Altering the NF-?B Signaling Pathway.
Regulation of proliferation of rat mammary tumor cells by inhibitors of cyclooxygenase and lipoxygenase.
Regulation of the cellular content of the organic osmolyte taurine in mammalian cells.
Relationship between lipoxygenase and human testicular cancer.
Requirement for autologous cancer extracts and lipoxygenation of arachidonic acid for human T-cell responses in leukocyte adherence inhibition and transmembrane potential change assays.
Role of arachidonic acid metabolites in tumor growth inhibition by nonsteroidal antiinflammatory drugs.
Role of eicosanoids in prostate cancer progression.
Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer.
Role of lipoxygenation in human natural killer cell activation.
Ruthenium(ii) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines.
Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid.
Specific lipoxygenase inhibition reverses macrophage cytotasis towards P815 tumor cells in vitro induced by the calcium ionophore A23187.
Structure of curcumin in complex with lipoxygenase and its significance in cancer.
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
Studies of synergistic and antagonistic combinations of conventional cytotoxic agents with the multiple eicosanoid pathway modulator LY 293111.
Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines.
Studies on the role of platelet eicosanoid metabolism and integrin alpha IIb beta 3 in tumor-cell-induced platelet aggregation.
Stylosin and some of its synthetic derivatives induce apoptosis in prostate cancer cells as 15-lipoxygenase enzyme inhibitors.
Suppression of endotoxin mitogenicity of spleen cells by lipoxygenase inhibitors and its reversal by 13-hydroxyoctadecadienoic acid.
Suppression of human cancer cell proliferation by lipoxygenase inhibitors and gamma-radiation in vitro.
Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism.
Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model.
Synthesis of eicosanoids by gamma-interferon-differentiated U937 cells.
Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry.
Tea antioxidants in cancer chemoprevention.
The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells.
The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8.
The effect of 15-lipoxygenase-1 expression on cancer cells.
The Effect of Diet Supplementation with Pomegranate and Bitter Melon on Lipidomic Profile of Serum and Cancerous Tissues of Rats with Mammary Tumours.
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
The in vitro development of cytotoxicity in response to granulocyte/macrophage-colony-stimulating factor or interferon gamma in the peripheral blood monocytes of patients with solid tumors: modulation by arachidonic acid metabolic inhibitors.
The induction of ornithine decarboxylase caused by 12-O-tetradecanoylphorbol-13-acetate in isolated epidermal cells is inhibited by lipoxygenase inhibitors but not by cyclooxygenase inhibitors.
The influence of arachidonic acid metabolites on cell division in the intestinal epithelium and in colonic tumors.
The involvement of macrophage-derived tumour necrosis factor and lipoxygenase products on the neutrophil recruitment induced by Clostridium difficile toxin B.
The linoleic acid metabolite, 13-HpODE augments the phosphorylation of EGF receptor and SHP-2 leading to their increased association.
The lipoxygenase metabolite 12(S)-HETE induces a cytoskeleton-dependent increase in surface expression of integrin alpha IIb beta 3 on melanoma cells.
The lipoxygenase metabolite, 12(S)-HETE, induces a protein kinase C-dependent cytoskeletal rearrangement and retraction of microvascular endothelial cells.
The mechanism of skin tumor promotion caused by phorbol esters: possible involvement of arachidonic acid cascade/lipoxygenase, protein kinase C and calcium/calmodulin systems.
The obesity-inflammation-eicosanoid axis in breast cancer.
The photoreceptor protector zeaxanthin induces cell death in neuroblastoma cells.
The potent anti-tumor-promoting agent isoliquiritigenin.
The role of cyclooxygenase and lipoxygenase in cancer chemoprevention.
The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma.
The role of inflammation in colon cancer.
The role of lipoxygenases in endotoxin-induced cytokine production.
The role of nutritional lipids and antioxidants in UV-induced skin cancer.
The role of platelet cyclooxygenase and lipoxygenase pathways in tumor cell induced platelet aggregation.
Toxoplasma gondii-induced immune suppression by human peripheral blood monocytes: role of gamma interferon.
Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.
Tumor cell-endothelial cell interactions: evidence for roles for lipoxygenase products of arachidonic acid in metastasis.
Tumor-cell-induced platelet aggregation is a glycoprotein-dependent and lipoxygenase-associated process.
UP446, analgesic and anti-inflammatory botanical composition.
[Advances in the research of lipoxygenase inhibitors]
[Effect of lysine clonixinate and indomethacin on lipoxygenase and cyclooxygenase activity in colon isolated from cancer patients]
[Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia]
[Growth inhibition and induction of tumor cell death by phospholipase A2 and lipoxygenase inhibitors]
[Relationship between the gene polymorphisms of oxidative metabolism enzyme of exogenous chemicals and the susceptibility to neoplasms].
[Synthesis of arachidonic acid cascade eicosanoids in tumors of various histogenesis in mice]
[Tumor promotion and arachidonic acid cascades]
Nephritis
Mechanisms underlying the anti-inflammatory effects of essential fatty acid deficiency in experimental glomerulonephritis. Inhibited release of a monocyte chemoattractant by glomeruli.
Nephrotic Syndrome
Structure-activity relationship for two lipoxygenase inhibitors and their potential for inducing nephrotic syndrome.
Nervous System Diseases
Docking Studies and Molecular Dynamics Simulation of Ipomoea batatas L. Leaves Compounds as Lipoxygenase (LOX) Inhibitor.
Neuralgia
Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats.
Neuroblastoma
Activation of cyclic nucleotide formation in murine neuroblastoma N1E-115 cells by modified human thrombins.
Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells.
Analysis of chromatin changes associated with the expression of globin and non-globin genes in cell hybrids between erythroid and other cells.
Conversion of arachidonic acid to cyclooxygenase and lipoxygenase products, and incorporation into phospholipids in the mouse neuroblastoma clone, Neuro-2A.
Cytosolic phospholipase A2 and lipoxygenase are involved in cell cycle progression in neuroblastoma cells.
Effect of inhibitors of eicosanoid metabolism on release of [3H]noradrenaline from the human neuroblastoma, SH-SY5Y.
Effects of delta 9-tetrahydrocannabinol and cannabidiol on phospholipase and other enzymes regulating arachidonate metabolism.
Inhibition of human malignant neuroblastoma cell DNA synthesis by lipoxygenase metabolites of arachidonic acid.
Nitric oxide-donor compounds inhibit lipoxygenase activity.
Novel 3-aryl-5-substituted-coumarin analogues: Synthesis and bioactivity profile.
Zinc Oxide Nanoparticles Exhibit Both Cyclooxygenase- and Lipoxygenase-Mediated Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells.
Neurodegenerative Diseases
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.
Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.
Galantamine potentiates the protective effect of rofecoxib and caffeic acid against intrahippocampal Kainic acid-induced cognitive dysfunction in rat.
Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.
Role of LOX/COX pathways in 3-nitropropionic acid-induced HD like symptoms in rats: Protective role of Licofelone.
Neuroinflammatory Diseases
Modulation of LOX and COX pathways via inhibition of amyloidogenesis contributes to mitoprotection against ?-amyloid oligomer-induced toxicity in an animal model of Alzheimer's disease in rats.
Obesity
Antioxidant supplementation and obesity have independent effects on hepatic oxylipin profiles in insulin-resistant, obesity-prone rats.
Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice.
Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides.
Obstetric Labor, Premature
Action of immunoregulatory agents on 5-HETE production by cultured human amnion cells.
Amniotic fluid arachidonate lipoxygenase metabolites in preterm labor.
Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor.
Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts.
Oligodendroglioma
mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.
Oligospermia
Mesalazine in treatment of psoriasis.
Osteoarthritis
15-Lipoxygenase-1 in osteoblasts promotes TGF-?1 expression via inhibiting autophagy in human osteoarthritis.
An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model.
Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells.
Elevated levels of 15-lipoxygenase-1 contribute to the abnormal phenotypes of osteoblasts in human osteoarthritis.
Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis.
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
In vivo effects of tepoxalin, an inhibitor of cyclooxygenase and lipoxygenase, on prostanoid and leukotriene production in dogs with chronic osteoarthritis.
Increased 15-lipoxygenase-1 expression in chondrocytes contributes to the pathogenesis of osteoarthritis.
Interactions of hydroxyapatite and fluorapatite particles on human osteoarthritis type B synoviocytes: effects on interleukin-1 alpha levels and lipoxygenase pathways.
Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines.
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
Osteosarcoma
Purification of Soluble Membrane-Bound Ambystoma mexicanum Epidermal Lipoxygenase from E. coli and Its Growth Effect on Human Fetal Foreskin Fibroblast.
Transforming growth factor-beta 1 inhibits lipoxygenase and epoxygenase eicosanoid production by osteosarcoma cells.
Otitis
Arabinogalactan- and dextran-induced ear inflammation in mice: differential inhibition by H1-antihistamines, 5-HT-serotonin antagonists and lipoxygenase blockers.
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin.
Otitis Media
Arachidonic acid metabolites in experimental otitis media and effects of anti-inflammatory drugs.
Otitis Media with Effusion
Experimental otitis media with effusion induced by platelet activating factor.
Ovarian Neoplasms
15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary.
Lipoxygenase pathway receptor expression in ovarian cancer.
Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival.
Overweight
[Isomeric specific analysis of hydroxyeicosatetraenoic acid in blood samples from obese patients with non-alcoholic and alcoholic steatohepatitis].
Pancreatic Neoplasms
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints.
Emerging drugs in pancreatic cancer.
Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors.
Hydroxyeicosatetraenoic acids in patients with pancreatic cancer: a preliminary report.
Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer.
Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells.
Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells.
Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.
Lipoxygenase inhibitors for the treatment of pancreatic cancer.
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
Molecular targeting therapy for pancreatic cancer.
Pancreatitis
Cyclooxygenase and lipoxygenase metabolism in sodium taurocholate induced acute hemorrhagic pancreatitis in rats.
Pancreatitis, Acute Hemorrhagic
Cyclooxygenase and lipoxygenase metabolism in sodium taurocholate induced acute hemorrhagic pancreatitis in rats.
Papilloma
Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.
[Factors controlling tumor promotion induced by TPA]
Paralysis
Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity.
Parasitemia
Effects of eicosanoid biosynthesis inhibitors on the prophenoloxidase-activating system and microaggregation reactions in the hemolymph of Rhodnius prolixus infected with Trypanosoma rangeli.
Parkinson Disease
Activity-Based Probes for 15-Lipoxygenase-1.
Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.
Pemphigoid, Bullous
12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation.
Periapical Periodontitis
Influence of cigarette smoking on synthesis of eicosanoids, isoprostanes and lipoxygenase metabolites in apical periodontitis.
Periodontal Diseases
Levels of leukotriene B4 in gingival crevicular fluid and gingival tissue in specific periodontal diseases.
Relative conversion of arachidonic acid through lipoxygenase and cyclooxygenase pathways by homogenates of diseased periodontal tissues.
[Evaluation of the biosynthesis of mono-HETES and leukotrienes in diseased periodontal tissues]
[The role of arachidonic and eicosapentaenoic acid lipoxygenase products in the pathogenesis of generalized parodontosis]
Peripheral Nervous System Diseases
Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil.
Peritonitis
Eicosanoid synthesis in human peritoneal macrophages stimulated with S. epidermidis.
Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis.
Pituitary Neoplasms
Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid.
Pleural Effusion
Quantitation of arachidonic acid lipoxygenase products in malignant and nonmalignant effusions.
Pleurisy
Involvement of leukotrienes in allergic pleurisy in actively sensitized rats: inhibition by the lipoxygenase inhibitor T-0757 of the increase in vascular permeability and leukotriene E4 production.
Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan.
Pharmacological studies on zymosan inflammation in rats and mice. 2: Zymosan-induced pleurisy in rats.
Pneumonia
Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.
[Interrelationship between lipoxygenase metabolites of arachidonic acid and pulmonary blood flow and ventilation in acute pneumonia]
Pneumoperitoneum
Comparison of peritoneal oxidative stress during laparoscopy and laparotomy.
Polycystic Kidney Diseases
Cyclooxygenase product inhibition with acetylsalicylic acid slows disease progression in the Han:SPRD-Cy rat model of polycystic kidney disease.
Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Renal cyclooxygenase and lipoxygenase products are altered in polycystic kidneys and by dietary soy protein and fish oil treatment in the Han:SPRD-Cy rat.
Polycystic Kidney, Autosomal Dominant
Bioactive lipid mediators in polycystic kidney disease.
Polycystic Kidney, Autosomal Recessive
Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Polycythemia
Deficiency of platelet lipoxygenase activity in myeloproliferative disorders.
[Defects in the prostaglandin system. IX. Lipoxygenase defect of thrombocytes in a patient with polycythemia vera]
Polycythemia Vera
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
[Defects in the prostaglandin system. IX. Lipoxygenase defect of thrombocytes in a patient with polycythemia vera]
Pre-Eclampsia
Lipoxygenase activity in human uterine and intrauterine tissues: new prospects for control of prostacyclin production in pre-eclampsia.
The role of arachidonic acid metabolites in preeclampsia.
[Significance of prostaglandins and other eicosanoids in the physiology and physiopathology of pregnancy]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death.
Premature Birth
Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers.
Primary Myelofibrosis
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Proctocolitis
Benoxaprofen in the treatment of active ulcerative colitis.
Prostatic Intraepithelial Neoplasia
Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.
DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation.
Prostatic Neoplasms
12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.
15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size).
15-lipoxygenase-1 expression upregulates and activates insulin-like growth factor-1 receptor in prostate cancer cells.
7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition.
8-Farnesyloxycoumarin induces apoptosis in PC-3 prostate cancer cells by inhibition of 15-lipoxygenase-1 enzymatic activity.
Cyclooxygenases and lipoxygenases in prostate and breast cancers.
DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation.
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Inhibition of lipoxygenase activity: implications for the treatment and chemoprevention of prostate cancer.
Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment.
Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.
Lipoxygenase inhibition in prostate cancer.
Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway.
Oncogenic action of phospholipase A2 in prostate cancer.
Oncogenic action of secreted phospholipase A2 in prostate cancer.
Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis.
Proapoptotic anti-inflammatory drugs.
Role of eicosanoids in prostate cancer progression.
The arachidonic Acid pathway and its role in prostate cancer development and progression.
Proteinuria
High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease.
The lipoxygenase inhibitor phenidone protects against proteinuria and stroke in stroke-prone spontaneously hypertensive rats.
Pruritus
Supplementation with n-3 and n-6 polyunsaturated fatty acids: effects on lipoxygenase activity and clinical symptoms of pruritus in hemodialysis patients.
Psoriasis
Chemotactic lipoxygenase products in psoriasis.
Chemotactic lipoxygenase products in sera from patients with psoriasis.
Clinical and biochemical effects of an oral leukotriene biosynthesis inhibitor (MK886) in psoriasis.
Effect of dithranol treatment on arachidonic acid and its lipoxygenase products in psoriasis.
Heterogeneous distribution of lipoxygenase products in psoriatic skin lesions.
Identification of chemotactic lipoxygenase products of arachidonate metabolism in psoriatic skin.
Inhibition of LOX by flavonoids: a structure-activity relationship study.
Lack of effect of topical indomethacin on psoriasis.
Leukotrienes and other lipoxygenase products in the pathogenesis and therapy of psoriasis and other dermatoses.
Leukotrienes C4 and D4 in psoriatic skin lesions.
Lipoxygenase inhibition and antioxidant properties of bisbenzylisoqunoline alkaloids isolated from Mahonia aquifolium.
Lipoxygenase inhibition and antioxidant properties of protoberberine and aporphine alkaloids isolated from Mahonia aquifolium.
Lipoxygenase products of arachidonic acid in psoriasis, atopic dermatitis, and experimental arthritis.
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Novel thiazolyl, thiazolinyl and benzothiazolyl Schiff bases as possible lipoxygenase's inhibitors and anti-inflammatory agents.
Pharmacology and significance of nonsteroidal anti-inflammatory drugs in the treatment of skin diseases.
Testing of lipoxygenase inhibitors, cyclooxygenase inhibitors, drugs with immunomodulating properties and some reference antipsoriatic drugs in the modified mouse tail test, an animal model of psoriasis.
The chemokinetic response of psoriatic and normal polymorphonuclear leukocytes to arachidonic acid lipoxygenase products.
The role of chemo-attractant lipoxygenase products in the pathogenesis of psoriasis.
Thiazolyl and benzothiazolyl Schiff bases as novel possible lipoxygenase inhibitors and anti inflammatory agents. Synthesis and biological evaluation.
[Essential fatty acids and the skin]
Pulmonary Atelectasis
Lipoxygenase and cyclooxygenase blockade by BW 755C enhances pulmonary hypoxic vasoconstriction.
Pulmonary Disease, Chronic Obstructive
Activity-Based Probes for 15-Lipoxygenase-1.
Chronic bronchitis: reflex on the pulmonary circulation.
Eicosanoids metabolized through LOX distinguish asthma-COPD overlap from COPD by metabolomics study.
Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1.
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
Pulmonary Edema
BW-755C diminishes smoke-induced pulmonary edema.
Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome.
Role of lipids in bone marrow-induced pulmonary edema.
Salutary effects of prostaglandin E1 in perfused rat lungs injured with hydrogen peroxide.
Pulmonary Fibrosis
Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguaiaretic acid. The role of alveolar macrophage activation and mediator production.
Radiation Pneumonitis
Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis.
Renal Artery Obstruction
New insights into the pathophysiology of renovascular hypertension.
Renal Insufficiency, Chronic
Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease.
Reperfusion Injury
Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function. Implications for pathogenesis of myocardial reperfusion injury.
Lipoxygenase inhibitor FLM 5011, an effective protectant of myocardial microvessels against ischemia-reperfusion injury? An ultrastructural-morphometric study.
Protease-activated receptor 2 protects against myocardial ischemia-reperfusion injury through the lipoxygenase pathway and TRPV1 channels.
The effects of lipoxygenase inhibitor and peptidoleukotriene antagonist on myocardial injury in a canine coronary occlusion-reperfusion model.
Respiratory Distress Syndrome
Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome.
Therapeutic intervention in a rat model of adult respiratory distress syndrome: II. Lipoxygenase pathway inhibition.
Respiratory Insufficiency
Dexamethasone and indomethacin modify endotoxin-induced respiratory failure in pigs.
Hydroxyeicosatetraenoic acids are increased in bronchoalveolar lavage fluid of endotoxemic pigs.
Retinal Detachment
Eicosanoid Profiles in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy.
Retinal Neovascularization
Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report.
Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-? and Down-Regulation of VEGFR-2 Expression.
Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression.
[Overexpression of 15-lipoxygenase-1 inhibits oxygen-induced retinal neovascularization in mice].
Rheumatic Diseases
Enzymic lipid peroxidation--a consequence of cell injury?
Rhinitis
Cyclooxygenase and lipoxygenase metabolite generation in nasal polyps.
Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients.
Rhinitis, Allergic
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Inhibition of LOX by flavonoids: a structure-activity relationship study.
Mast cell stabilization, lipoxygenase inhibition, hyaluronidase inhibition, antihistaminic and antispasmodic activities of Aller-7, a novel botanical formulation for allergic rhinitis.
Sarcoma
Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.
Scleroderma, Systemic
Benoxaprofen in treatment of systemic sclerosis.
Seizures
Brain microvessel 12-hydroxyeicosatetraenoic acid is the (S) enantiomer and is lipoxygenase derived.
Convulsions induced by canatoxin in rats are probably a consequence of hypoxia.
Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Leukotriene C4 and prostaglandin E2 activities in the serum and cerebrospinal fluid during acute cerebral ischemia.
The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy.
The ALOXE3 gene variants from patients with Dravet syndrome decrease gene expression and enzyme activity.
The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity.
Sepsis
Activity of the lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone) and derivatives on the inhibition of adhesion molecule expression on human umbilical vascular endothelial cells.
Characteristics of alveolar macrophages in experimental septic lung.
Effect of cyclooxygenase and lipoxygenase products on pulmonary function in group B streptococcal sepsis.
Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats.
Inhibition of eicosanoid production by BW755C does not attenuate sepsis-induced alterations in glucose kinetics.
Phospholipids and their inhibitors: a critical evaluation of their role in the treatment of sepsis.
Secreted lipoxygenase from Pseudomonas aeruginosa exhibits biomembrane oxygenase activity and induces hemolysis in human red blood cells.
Shock, Septic
Beneficial effects of a leukotriene antagonist on endotoxin-induced acute hemodynamic alterations.
Differential protective activities of site specific lipoxygenase inhibitors in endotoxic shock and production of tumor necrosis factor.
Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats.
Effects of two different inhibitors of the arachidonic acid metabolism on platelet sequestration in endotoxic shock.
Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock.
[Effects of anti-toxic agents in septic shock]
Skin Diseases
Effects of chronic intracutaneous administration of arachidonic acid and its metabolites. Induction of leukocytoclastic vasculitis by leukotriene B4 and 12-hydroxyeicosatetraenoic acid and its prevention by prostaglandin E2.
Inhibitory effects of sulfonated shale oils (ammonium bituminosulphonates, Ichthyols) on enzymes of polyenoic fatty acid metabolism.
Interferon-gamma-induced 15-lipoxygenase-2 expression in normal human epidermal keratinocytes and a pathogenic link to psoriasis vulgaris.
Leukotrienes and other lipoxygenase products in the pathogenesis and therapy of psoriasis and other dermatoses.
Pharmacology and significance of nonsteroidal anti-inflammatory drugs in the treatment of skin diseases.
[Essential fatty acids and the skin]
Spasm
CSF leukotriene C4 following subarachnoid hemorrhage.
Molsidomine: alternative approaches to treat myocardial ischemia.
[The effect of indomethacin on the changes in the hemodynamics and coronary vascular resistance during anaphylactic shock]
Starvation
Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation.
The potassium-dependent transcriptome of Arabidopsis reveals a prominent role of jasmonic acid in nutrient signaling.
Status Epilepticus
Effect of bicuculline-induced status epilepticus on prostaglandins and hydroxyeicosatetraenoic acids in rat brain subcellular fractions.
The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy.
Stomach Neoplasms
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
Stomach Ulcer
Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats.
Stroke
Activity-Based Probes for 15-Lipoxygenase-1.
Brain microvessel 12-hydroxyeicosatetraenoic acid is the (S) enantiomer and is lipoxygenase derived.
Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research.
Lipoxygenase: An Emerging Target for Stroke Therapy.
The lipoxygenase inhibitor phenidone protects against proteinuria and stroke in stroke-prone spontaneously hypertensive rats.
Stupor
The role of specific eicosanoids in mediating the acute narcotic effects of ethanol.
Subarachnoid Hemorrhage
Cerebral arteries can generate 5- and 15-hydroxyeicosatetraenoic acid from arachidonic acid.
Effect of high-dose methylprednisolone and U74006F on eicosanoid synthesis after subarachnoid hemorrhage in rats.
Participation of lipoxygenase products from arachidonic acid in the pathogenesis of cerebral vasospasm.
Sunburn
Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids.
Synovitis
[Pathogenesis and therapy of rheumatoid inflammation]
Testicular Neoplasms
Relationship between lipoxygenase and human testicular cancer.
Tetanus
Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: an in vivo study in the dentate gyrus of the rat.
Thrombocythemia, Essential
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Aspirin increases the bleeding side effects in essential thrombocythemia independent of the cyclooxygenase pathway: role of the lipoxygenase pathway.
Lipoxygenase deficiency in primary thrombocythemia is not a true deficiency.
Thrombocytopenia
Intravenous injections of PAF-acether induce platelet aggregation in rats.
Involvement of eicosanoids and PAF in immune-complex alveolitis.
Thrombocytosis
Deficiency of platelet lipoxygenase activity in myeloproliferative disorders.
Thrombosis
Cyclooxygenase, lipoxygenase and tumor angiogenesis.
Deficiency of platelet lipoxygenase activity in myeloproliferative disorders.
Deficient induction of leukotriene synthesis in human neutrophils by lipoxygenase-deficient platelets.
Leukocyte mediated vein injury and thrombosis is reduced by a lipoxygenase inhibitor.
Platelet adhesivity to subendothelium is influenced by polymorphonuclear leukocytes: studies with aspirin and salicylate.
Thymoma
Incorporation of 5,8,11,14-eicosatetraynoic acid (ETYA) into cell lipids: competition with arachidonic acid for esterification.
Thyroid Cancer, Papillary
Arachidonate 5 lipoxygenase expression in papillary thyroid carcinoma promotes invasion via MMP-9 induction.
Uremia
[The level of thromboxane A2 and prostacyclin in patients with chronic kidney failure undergoing hemodialysis]
Urinary Bladder Neoplasms
Antitumor effects of lipoxygenase inhibitors on murine bladder cancer cell line (MBT-2).
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Polyunsaturated fatty acid metabolizing 15-Lipoxygenase-1 (15-LO-1) expression in normal and tumorigenic human bladder tissues.
Urologic Neoplasms
Lipoxygenase inhibitors prevent urological cancer cell growth.
Uveitis
Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin.
Effects of lipoxygenase inhibitors in a model of lens-induced uveitis in dogs.
The role of endogenous eicosanoids in rabbit-intraocular inflammation.
Treatment of experimental granulomatous uveitis by lipoxygenase and cyclo-oxygenase inhibitors.
[Effect of topical pranoprofen on the lipoxygenase metabolism of the arachidonic and in endotoxin-induced uveitis]
Vaccinia
Poxvirus-induced alteration of arachidonate metabolism.
Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine.
Vascular Calcification
[Arachidonic acid Alox15/12-HETE signaling inhibits vascular calcification].
Vascular Diseases
Atherosclerosis and oxidative stress.
Vascular Ring
Platelets enhance anoxic contraction of rat aortic rings through platelet-activating factor-dependent mechanism.
Vascular System Injuries
Influence of steroidal and nonsteroidal anti-inflammatory agents on the accumulation of arachidonic acid metabolites in plasma and lung lymph after endotoxemia in awake sheep. Measurements of prostacyclin and thromboxane metabolites and 12-HETE.
Lipoxygenase inhibition decreases neointimal formation following vascular injury.
Mechanisms of lung injury.
Vasculitis
Effects of chronic intracutaneous administration of arachidonic acid and its metabolites. Induction of leukocytoclastic vasculitis by leukotriene B4 and 12-hydroxyeicosatetraenoic acid and its prevention by prostaglandin E2.
Vasospasm, Intracranial
Cerebral arteries can generate 5- and 15-hydroxyeicosatetraenoic acid from arachidonic acid.
Ebselen (DR3305) ameliorates delayed cerebral vasospasm in a canine two-hemorrhage model.
Participation of lipoxygenase products from arachidonic acid in the pathogenesis of cerebral vasospasm.
Ventricular Dysfunction
Lipoxygenase inhibitor nafazatrom fails to attenuate postischaemic ventricular dysfunction.
Ventricular Fibrillation
Modulation of arachidonic acid metabolites and vulnerability to ventricular fibrillation during myocardial ischemia in the cat.
Virus Diseases
Antisense expression of a omega-3 fatty acid desaturase gene in tobacco plants enhances susceptibility against pathogens.
Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model.
Vitamin E Deficiency
In vitro and in vivo effects of vitamin E on arachidonic acid metabolism in rat platelets.
[Activation of lipoxygenase, neuraminidase and phospholipase A in cellular and subcellular membranes in carbon tetrachloride poisoning and vitamin E deficiency]
Whooping Cough
Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel.
Astrocytes are target cells for endothelins and sarafotoxin.
Epinephrine impairs insulin release by a mechanism distal to calcium mobilization. Similarity to lipoxygenase inhibitors.
Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta.
Pertussis toxin and H-7 distinguish mechanisms involved in eicosanoid release from lipopolysaccharide-primed macrophages. Eicosanoid release from lipopolysaccharide-primed macrophages.
Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells.
Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid.
The bradykinin receptor--a putative receptor-operated channel in PC12 cells: studies of neurotransmitter release and inositol phosphate accumulation.
Wiskott-Aldrich Syndrome
A novel arachidonic acid metabolite with stimulatory effect on PHA-induced mitogenesis of lymphocytes.
Zellweger Syndrome
Lipoxygenase metabolites in amniotic fluid of patients with Zellweger syndrome.