Disease on EC 1.11.2.3 - plant seed peroxygenase
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Acute Coronary Syndrome
[The frequency of polymorphism in promoter gene coding epoxygenase 2J2 in patents with acute coronary syndrome]
Asthma
Promoter polymorphism G-50T of a human CYP2J2 epoxygenase gene is associated with common susceptibility to asthma.
Atherosclerosis
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta.
Brain Injuries
A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow.
Breast Neoplasms
CYP3A4 mediates growth of ER+ breast cancer cells, in part, by nuclear translocation of phospho-Stat3 through biosynthesis of ({+/-})-14,15-EET.
Breast Neoplasms
Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer.
Carcinogenesis
Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.
Carcinoma, Hepatocellular
CYP2J2 promotes the development of hepatocellular carcinoma by increasing the EETs production to improve HIF-1? stability.
Cardiomegaly
Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol.
Cardiovascular Diseases
Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitors.
Cardiovascular Diseases
CYP2J2 epoxygenase membrane anchor plays an important role in facilitating electron transfer from CPR.
Cardiovascular Diseases
Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation.
Cardiovascular Diseases
Cytochrome P450 Pathway Contributes to Methanandamide-induced Vasorelaxation in Rat Aorta.
Cardiovascular Diseases
Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling.
Cardiovascular Diseases
Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk.
Cardiovascular Diseases
Soluble epoxide hydrolase null mice exhibit female and male differences in regulation of vascular homeostasis.
Coronary Artery Disease
Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease.
Coronary Artery Disease
Letter to the editor regarding "Role of cytochrome epoxygenase (CYP2J2) in the pathophysiology of coronary artery disease in South Indian Population."
Coronary Artery Disease
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.
Coronary Artery Disease
Role of cytochrome epoxygenase (CYP2J2) in the pathophysiology of coronary artery disease in South Indian population.
Dehydration
Identification of Arabidopsis candidate genes in response to biotic and abiotic stresses using comparative microarrays.
Diabetes Mellitus, Type 2
Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History.
Diabetes, Gestational
The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process.
Diabetic Cardiomyopathies
Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.
Diabetic Cardiomyopathies
CYP-450 Epoxygenase Derived Epoxyeicosatrienoic Acid Contribute To Reversal of Heart Failure in Obesity-Induced Diabetic Cardiomyopathy via PGC-1 ? Activation.
Diabetic Nephropathies
Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice.
Diabetic Nephropathies
Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy.
Essential Hypertension
The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population.
Fatty Liver
The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.
Glioma
Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme.
Head and Neck Neoplasms
The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells.
Heart Failure
CYP-450 Epoxygenase Derived Epoxyeicosatrienoic Acid Contribute To Reversal of Heart Failure in Obesity-Induced Diabetic Cardiomyopathy via PGC-1 ? Activation.
Heart Failure
Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-?-induced injury.
Hydrocephalus
Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4.
Hypercholesterolemia
Altered mechanisms of endothelium-dependent dilation in skeletal muscle arterioles with genetic hypercholesterolemia.
Hypercholesterolemia
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta.
Hyperemia
Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats.
Hyperemia
Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans.
Hyperemia
Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors.
Hypertension
Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance.
Hypertension
Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system.
Hypertension
Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.
Hypertension
Gene Delivery of a Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-induced Pulmonary Artery Hypertension in Rats.
Hypertension
IL6 suppression provides renal protection independent of blood pressure in a murine model of salt-sensitive hypertension.
Hypertension
Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice.
Hypertension
Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats.
Hypertension
Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats.
Hypertension
Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage.
Hypertension
Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension.
Hypertension
The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population.
Hypertension
The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt.
Hypertension
The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension.
Hypertension, Portal
Arachidonic acid metabolites and endothelial dysfunction of portal hypertension.
Hypertension, Pulmonary
Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.
Hypertension, Pulmonary
Gene Delivery of a Cytochrome P450 Epoxygenase Ameliorates Monocrotaline-induced Pulmonary Artery Hypertension in Rats.
Hypotension
Cytochrome P-450 arachidonate metabolite inhibition improves renal function in Lyon hypertensive rats.
Infarction, Middle Cerebral Artery
Soluble epoxide hydrolase: a novel therapeutic target in stroke.
Infections
A Caleosin-Like Protein with Peroxygenase Activity Mediates Aspergillus flavus Development, Aflatoxin Accumulation, and Seed Infection.
Infections
Effects of cytochrome P450 arachidonic acid epoxygenases on the proliferation of tumor cells.
Infections
Identification of Arabidopsis candidate genes in response to biotic and abiotic stresses using comparative microarrays.
Infections
Involvement of RD20, a member of caleosin family, in ABA-mediated regulation of germination in Arabidopsis thaliana.
Infections
Roles of a membrane-bound caleosin and putative peroxygenase in biotic and abiotic stress responses in Arabidopsis.
Insulin Resistance
Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.
Insulin Resistance
CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPAR?.
Insulin Resistance
Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice.
Insulin Resistance
The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process.
Ischemic Stroke
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Liver Diseases
CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.
Liver Diseases
The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.
Lung Injury
Epoxyeicosatrienoates are the dominant eicosanoids in human lungs upon microbial challenge.
Metabolic Syndrome
Soluble epoxide hydrolase null mice exhibit female and male differences in regulation of vascular homeostasis.
Multiple Myeloma
Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells.
Myocardial Infarction
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Myocardial Infarction
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.
Myocardial Infarction
Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction.
Myocardial Ischemia
Cytochrome p450 2C (CYP2C) in ischemic heart injury and vascular dysfunction.
Myocardial Reperfusion Injury
Expression of epoxygenases belonging to CYP2 family in rat myocardial ischemia/reperfusion injury in vivo.
Neoplasms
Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme.
Neoplasms
CYP epoxygenase derived EETs: from cardiovascular protection to human cancer therapy.
Neoplasms
CYP2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth.
Neoplasms
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.
Neoplasms
Effects of cytochrome P450 arachidonic acid epoxygenases on the proliferation of tumor cells.
Neoplasms
Epoxyeicosatrienoic Acids Attenuate Reactive Oxygen Species level, Mitochondrial Dysfunction, Caspase Activation and Apoptosis in Carcinoma Cells Treated with Arsenic Trioxide.
Neoplasms
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.
Neoplasms
Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats.
Neoplasms
Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer.
Neoplasms
Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2.
Neoplasms
P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells.
Neoplasms
Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.
Neoplasms
Targeting cytochrome P450-dependent cancer cell mitochondria: cancer associated CYPs and where to find them.
Neoplasms
The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated.
Neoplasms
The epoxyeicosatrienoic acid-stimulated phosphorylation of EGF-R involves the activation of metalloproteinases and the release of HB-EGF in cancer cells.
Obesity
Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes.
Osteosarcoma
Transforming growth factor-beta 1 inhibits lipoxygenase and epoxygenase eicosanoid production by osteosarcoma cells.
Polycystic Kidney Diseases
Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Polycystic Kidney, Autosomal Recessive
Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Prostatic Neoplasms
The arachidonic Acid pathway and its role in prostate cancer development and progression.
Renal Insufficiency, Chronic
Urinary CYP eicosanoid excretion correlates with glomerular filtration in African-Americans with chronic kidney disease.
Reperfusion Injury
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
Reperfusion Injury
Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart.
Whooping Cough
Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes.
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