Disease on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase

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Adenocarcinoma
Tissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma.
Adenoma
Inverse mRNA expression of the selenocysteine-containing proteins GI-GPx and SeP in colorectal adenomas compared with adjacent normal mucosa.
Alzheimer Disease
Association of selenoprotein p with Alzheimer's pathology in human cortex.
Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.
Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain.
Role of selenoprotein P in Alzheimer's disease.
Selenium, selenoprotein P, and Alzheimer's disease: is there a link?
Selenoprotein P and its potential role in Alzheimer's disease.
Aortic Aneurysm, Abdominal
Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure.
SEPP1 gene variants and abdominal aortic aneurysm: gene association in relation to metabolic risk factors and peripheral arterial disease coexistence.
Asthma
Maternal selenium status in pregnancy, offspring glutathione peroxidase 4 genotype, and childhood asthma.
Atherosclerosis
Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells.
Selenium in the prevention of atherosclerosis and its underlying mechanisms.
Serum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis.
Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice.
Bacterial Infections
Four selenoprotein P genes exist in salmonids: Analysis of their origin and expression following Se supplementation and bacterial infection.
GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis.
Barrett Esophagus
Genetic Variation in GPX1 Is Associated with GPX1 Activity in a Comprehensive Analysis of Genetic Variations in Selenoenzyme Genes and Their Activity and Oxidative Stress in Humans.
Bile Duct Neoplasms
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
Biliary Tract Neoplasms
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
Brain Injuries
Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage.
Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury.
Breast Neoplasms
Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk.
Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells.
Impaired expression of glutathione peroxidase-4 gene in peripheral blood mononuclear cells: A biomarker of increased breast cancer risk.
Phospholipid hydroperoxide glutathione peroxidase induces a delay in G1 of the cell cycle.
Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy.
Selenium and cancer: a story that should not be forgotten-insights from genomics.
Burkitt Lymphoma
Cloning of phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an anti-apoptotic and growth promoting gene of Burkitt lymphoma cells.
Carcinogenesis
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.
Carcinoma
Inverse regulation of lipid-peroxidizing and hydroperoxyl lipid-reducing enzymes by interleukins 4 and 13.
PHGPx overexpression induces an increase in COX-2 activity in colon carcinoma cells.
Selenoprotein P in colitis-associated carcinoma.
[Overexpression of SEPP1 inhibits the proliferation and induces cell cycle G2/M arrest of 786-O and 769-P human renal carcinoma cells].
Carcinoma, Ductal
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma.
Carcinoma, Hepatocellular
Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells.
Direct separation of hydroperoxy- and hydroxy-phosphatidylcholine derivatives: application to the assay of phospholipid hydroperoxide glutathione peroxidase.
Hepatitis B virus X protein induces TNF-alpha expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2.
Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma.
Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression.
mRNA stability and selenocysteine insertion sequence efficiency rank gastrointestinal glutathione peroxidase high in the hierarchy of selenoproteins.
Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice.
Polysome distribution of phospholipid hydroperoxide glutathione peroxidase mRNA: evidence for a block in elongation at the UGA/selenocysteine codon.
Possible involvement of reactive oxygen species in D-galactosamine-induced sensitization against tumor necrosis factor-alpha-induced hepatocyte apoptosis.
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma.
Selective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supply.
Selenoprotein P mRNA expression in human hepatic tissues.
Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor.
Carcinoma, Renal Cell
[Overexpression of SEPP1 inhibits the proliferation and induces cell cycle G2/M arrest of 786-O and 769-P human renal carcinoma cells].
Carcinoma, Squamous Cell
Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells.
Inhibition of arachidonate metabolism in human epidermoid carcinoma a431 cells overexpressing phospholipid hydroperoxide glutathione peroxidase.
Involvement of reactive oxygen species in arsenite-induced downregulation of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells.
Regulation of cyclooxygenase and 12-lipoxygenase catalysis by phospholipid hydroperoxide glutathione peroxidase in A431 cells.
The CCAAT-box binding factor NF-Y is required for the expression of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells.
Cardiomegaly
Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice.
Cardiotoxicity
Protective effect of dietary selenium supplementation on delayed cardiotoxicity of adriamycin in rat: is PHGPX but not GPX involved?
Cardiovascular Diseases
Association of expression of selenoprotein P in mRNA and protein levels with metabolic syndrome in subjects with cardiovascular disease: Results of the Selenegene study.
Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy.
Proposal of a study protocol of a preliminary double-blind randomized controlled trial. Verifying effects of selenium supplementation on selenoprotein p and s genes expression in protein and mRNA levels in subjects with coronary artery disease: selenegene.
Cataract
Effect of plant-based feed ingredients on osmoregulation in the Atlantic salmon lens.
Serum selenium levels are associated with age-related cataract.
Cerebral Hemorrhage
Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage.
Cholangiocarcinoma
Vitellocyte-specific expression of phospholipid hydroperoxide glutathione peroxidases in Clonorchis sinensis.
Choline Deficiency
A Comparative Study on Antioxidant System in Fish Hepatopancreas and Intestine Affected by Choline Deficiency: Different Change Patterns of Varied Antioxidant Enzyme Genes and Nrf2 Signaling Factors.
Choroidal Neovascularization
Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice.
Colonic Neoplasms
Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis.
Colorectal Neoplasms
Aberrant expression of selenoproteins in the progression of colorectal cancer.
Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer.
Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells.
Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction.
Selenium and cancer: a story that should not be forgotten-insights from genomics.
Coronary Artery Disease
Proposal of a study protocol of a preliminary double-blind randomized controlled trial. Verifying effects of selenium supplementation on selenoprotein p and s genes expression in protein and mRNA levels in subjects with coronary artery disease: selenegene.
Cryptorchidism
Phospholipid hydroperoxide glutathione peroxidase is involved in the maintenance of male fertility under cryptorchidism in mice.
Death, Sudden, Cardiac
Selenoprotein P and Yunnan endemic sudden cardiac death--an ecological study.
Diabetes Complications
Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes.
Testis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidine-treated diabetic rats.
Diabetes Mellitus
Selenium Levels in Community Dwellers with Type 2 Diabetes Mellitus.
Selenium supplementation trials for cancer prevention and the subsequent risk of type 2 diabetes mellitus:.
Selenoprotein P is not elevated in gestational diabetes mellitus.
[Selenoprotein P in type 2 diabetes mellitus and its association with insulin resistance].
Diabetes Mellitus, Type 1
Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes.
Sex-specific associations of variants in regulatory regions of NADPH oxidase-2 (CYBB) and glutathione peroxidase 4 (GPX4) genes with kidney disease in type 1 diabetes.
Diabetes Mellitus, Type 2
Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
Identification of hepatokines involved in pathology of type 2 diabetes and obesity.
Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes.
Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes.
Pathophysiological significance of hepatokine overproduction in type 2 diabetes.
Selenium Levels in Community Dwellers with Type 2 Diabetes Mellitus.
Selenium supplementation trials for cancer prevention and the subsequent risk of type 2 diabetes mellitus:.
Selenoprotein P is not elevated in gestational diabetes mellitus.
Serum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis.
[Selenoprotein P in type 2 diabetes mellitus and its association with insulin resistance].
Diabetes, Gestational
Selenoprotein P is not elevated in gestational diabetes mellitus.
The relationship between gestational diabetes mellitus and selenoprotein-P plasma 1 (SEPP1) gene polymorphisms.
Dry Eye Syndromes
Autologous Serum and Serum Components.
Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals.
Encephalomyelitis
Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis.
Endometriosis
Higher SOD1 Gene Expression in Cumulus Cells From Infertile Women With Moderate and Severe Endometriosis.
Esophageal Neoplasms
Genetic Variation in GPX1 Is Associated with GPX1 Activity in a Comprehensive Analysis of Genetic Variations in Selenoenzyme Genes and Their Activity and Oxidative Stress in Humans.
Essential Hypertension
The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension.
Fowlpox
SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes.
Glioma
Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells.
RSL3 induced autophagic death in glioma cells via causing glycolysis dysfunction.
Glucose Intolerance
Identification of hepatokines involved in pathology of type 2 diabetes and obesity.
Graves Disease
Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study.
Hepatitis B
Hepatitis B virus X protein induces TNF-alpha expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2.
Hepatitis C
Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.
Hepatitis C, Chronic
Alterations in serum levels of fetuin A and selenoprotein P in chronic hepatitis C patients with concomitant type 2 diabetes: A case-control study.
Hypercholesterolemia
Diet-induced obesity in the selenocysteine lyase knockout mouse.
Hyperglycemia
Attenuation of hepatic expression and secretion of selenoprotein P by metformin.
Circulating concentrations of insulin resistance-associated hepatokines, selenoprotein P and leukocyte cell-derived chemotaxin 2, during an oral glucose tolerance test in humans.
Pathophysiological significance of hepatokine overproduction in type 2 diabetes.
Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.
Hyperinsulinism
Diet-induced obesity in the selenocysteine lyase knockout mouse.
Hypersensitivity
Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans.
Reverse genetic analysis of the glutathione metabolic pathway suggests a novel role of PHGPX and URE2 genes in aluminum resistance in Saccharomyces cerevisiae.
Selenoperoxidase-mediated cytoprotection against the damaging effects of tert-butyl hydroperoxide on leukemia cells.
Hypertension
Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target.
Hypothyroidism
Selenium and its relationship with selenoprotein P and glutathione peroxidase in children and adolescents with Hashimoto's thyroiditis and hypothyroidism.
Idiopathic Pulmonary Fibrosis
Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.
Infections
Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.
Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission.
Four selenoprotein P genes exist in salmonids: Analysis of their origin and expression following Se supplementation and bacterial infection.
Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.
Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase.
The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration.
Infertility
Essential role of the apolipoprotein E receptor-2 in sperm development.
Genetic variations of gpx-4 and male infertility in humans.
Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice.
Molecular genetics of human male infertility: from genes to new therapeutic perspectives.
[Biological significance of lipid hydroperoxide and its reducing enzyme, phospholipid hydroperoxide glutathione peroxidase, in mammalian cells]
Infertility, Male
Genetic variations of gpx-4 and male infertility in humans.
Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase.
Male subfertility induced by heterozygous expression of catalytically inactive glutathione peroxidase 4 is rescued in vivo by systemic inactivation of the Alox15 gene.
Mitochondrial glutathione peroxidase 4 disruption causes male infertility.
New Strategy of Functional Analysis of PHGPx Knockout Mice Model Using Transgenic Rescue Method and Cre-LoxP System.
Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels.
Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation.
[Association between single nucleotide polymorphisms of 5'-untranslated region of GPx4 gene and male infertility].
Insulin Resistance
A liver-derived secretory protein, selenoprotein P, causes insulin resistance.
Alterations in serum levels of fetuin A and selenoprotein P in chronic hepatitis C patients with concomitant type 2 diabetes: A case-control study.
AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P in HepG2 hepatocytes.
Circulating concentrations of insulin resistance-associated hepatokines, selenoprotein P and leukocyte cell-derived chemotaxin 2, during an oral glucose tolerance test in humans.
Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases.
Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
Evaluation of endothelial dysfunction in patients with nonalcoholic fatty liver disease: Association of selenoprotein P with carotid intima-media thickness and endothelium-dependent vasodilation.
Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK.
Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics.
Increased selenoprotein p levels in subjects with visceral obesity and nonalcoholic Fatty liver disease.
Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.
Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes.
Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes.
Pathophysiological significance of hepatokine overproduction in type 2 diabetes.
Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression.
Role of Supplementary Selenium on the Induction of Insulin Resistance and Oxidative Stress in NSY Mice Fed a High Fat Diet.
S-Adenosylmethionine Dependent Protein Methylation is Required for Expression of Selenoprotein P and Gluconeogenic Enzymes in Human Hepatocytes.
Salsalate and Adiponectin Improve Palmitate-Induced Insulin Resistance via Inhibition of Selenoprotein P through the AMPK-FOXO1? Pathway.
Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.
Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance.
Selenoprotein P is not elevated in gestational diabetes mellitus.
Serum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis.
Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.
The relationship between gestational diabetes mellitus and selenoprotein-P plasma 1 (SEPP1) gene polymorphisms.
[Selenoprotein P in type 2 diabetes mellitus and its association with insulin resistance].
Insulinoma
Biosynthesis of hepoxilins: evidence for the presence of a hepoxilin synthase activity in rat insulinoma cells.
Intestinal Diseases
Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease.
Kashin-Beck Disease
Selenoprotein P gene r25191g/a polymorphism and quantification of selenoprotein P mRNA level in patients with Kashin-Beck disease.
SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease.
Kidney Diseases
Sex-specific associations of variants in regulatory regions of NADPH oxidase-2 (CYBB) and glutathione peroxidase 4 (GPX4) genes with kidney disease in type 1 diabetes.
Kidney Neoplasms
Selenoprotein P status correlates to cancer-specific mortality in renal cancer patients.
Leukemia
Alteration of gene expressions by the overexpression of mitochondrial phospholipid hydroperoxide glutathione peroxidase (mtPHGPx).
Amplification and hyperexpression of the catalase gene in selenoperoxidase-deficient leukemia cells.
Cytoprotection against merocyanine 540-sensitized photoinactivation of the Na+,K(+)-adenosine triphosphatase in leukemia cells: glutathione and selenoperoxidase involvement.
Induction of phospholipid hydroperoxide glutathione peroxidase in human polymorphonuclear neutrophils and HL60 cells stimulated with TNF-alpha.
Overexpression of phospholipid hydroperoxide glutathione peroxidase suppressed cell death due to oxidative damage in rat basophile leukemia cells (RBL-2H3).
Selenoperoxidase-mediated cytoprotection against merocyanine 540-sensitized photoperoxidation and photokilling of leukemia cells.
Leukemia L1210
Hyperexpression of catalase in selenium-deprived murine L1210 cells.
Selenoperoxidase-dependent glutathione cycle activity in peroxide-challenged leukemia cells.
Liver Cirrhosis
Selenoprotein P mRNA expression in human hepatic tissues.
Liver Diseases
Evaluation of endothelial dysfunction in patients with nonalcoholic fatty liver disease: Association of selenoprotein P with carotid intima-media thickness and endothelium-dependent vasodilation.
Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK.
Increased selenoprotein p levels in subjects with visceral obesity and nonalcoholic Fatty liver disease.
Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma.
Selenium and selenoprotein P in nonalcoholic fatty liver disease.
Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease.
Lung Neoplasms
A prospective study of plasma Selenoprotein P and lung cancer risk among low-income adults.
Plasma selenoprotein P concentration and lung cancer risk: Results from a case-control study nested within the Shanghai Men's Health Study.
Selenium and cancer: a story that should not be forgotten-insights from genomics.
Lymphoma, B-Cell
Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma.
Melanoma
Integrated proteomics pipeline yields novel biomarkers for predicting preeclampsia.
Metabolic Diseases
Green tea extracts reduce leukocyte cell-Derived chemotaxin 2 and selenoprotein P levels in the livers of C57BL/6J mice fed a high-fat diet.
Metabolic Syndrome
Association of expression of selenoprotein P in mRNA and protein levels with metabolic syndrome in subjects with cardiovascular disease: Results of the Selenegene study.
Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children.
Movement Disorders
Selenium and brain function: a poorly recognized liaison.
Multiple Sclerosis
Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis.
Muscular Atrophy
Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria.
Muscular Diseases
Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.
Myocardial Infarction
Selenoprotein P in Myocardial Infarction with Cardiogenic Shock.
Neonatal Sepsis
Oxidant and antioxidant status in neonatal proven and clinical sepsis according to selenium status.
Neoplasm Metastasis
Tissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma.
Neoplasms
A thin layer chromatographic method for determining the enzymatic activity of peroxidases catalyzing the two-electron reduction of lipid hydroperoxides.
Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity.
Accurate Quantification of Selenoprotein P (SEPP1) in Plasma Using Isotopically Enriched Seleno-peptides and Species-Specific Isotope Dilution with HPLC Coupled to ICP-MS/MS.
BID links ferroptosis to mitochondrial cell death pathways.
Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy.
Chaperone-mediated autophagy is involved in the execution of ferroptosis.
Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells.
Effect of selenium on expression of selenoproteins in mouse fibrosarcoma cells.
Effects of selenium status, dietary glucosinolate intake and serum glutathione S-transferase ? activity on the risk of benign prostatic hyperplasia.
Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species.
Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial.
Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation.
Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc?1 cancer stem?like cells.
Glutathione peroxidases and redox-regulated transcription factors.
Hepatic Arterial Infusion of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles Selectively Disrupts Redox Balance in Hepatoma Cells and Reduces Growth of Orthotopic Liver Tumors in Rats.
Hepatitis B virus X protein induces TNF-alpha expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2.
High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs.
Inhibitory effect of phospholipid hydroperoxide glutathione peroxidase on the activity of lipoxygenases and cyclooxygenases.
Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk.
JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.
Metadherin enhances vulnerability of cancer cells to ferroptosis.
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release.
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma.
Phospholipid hydroperoxide glutathione peroxidase is the 18-kDa selenoprotein expressed in human tumor cell lines.
Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity.
Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy.
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis.
Relative abundance of selenoprotein p isoforms in human plasma depends on genotype, se intake, and cancer status.
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort.
Selenium supplementation trials for cancer prevention and the subsequent risk of type 2 diabetes mellitus:.
Selenium, but not lycopene or vitamin E, decreases growth of transplantable dunning R3327-H rat prostate tumors.
Selenoperoxidase-dependent glutathione cycle activity in peroxide-challenged leukemia cells.
Selenoprotein P in colitis-associated carcinoma.
Selenoprotein P in plasma in relation to cancer morbidity in middle-aged Swedish men.
Selenoproteins and human health: Insights from epidemiological data.
Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach.
Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase.
The Role of Ferroptosis in Cancer Development and Treatment Response.
Tissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma.
Non-alcoholic Fatty Liver Disease
Evaluation of endothelial dysfunction in patients with nonalcoholic fatty liver disease: Association of selenoprotein P with carotid intima-media thickness and endothelium-dependent vasodilation.
Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK.
Increased selenoprotein p levels in subjects with visceral obesity and nonalcoholic Fatty liver disease.
Non-alcoholic fatty liver disease in the first trimester and subsequent development of gestational diabetes mellitus.
Selenium and selenoprotein P in nonalcoholic fatty liver disease.
Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease.
Obesity
Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
Identification of hepatokines involved in pathology of type 2 diabetes and obesity.
Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy.
Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance.
Obesity, Abdominal
Increased selenoprotein p levels in subjects with visceral obesity and nonalcoholic Fatty liver disease.
Ovarian Neoplasms
Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity.
Pancreatic Neoplasms
Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells.
Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase.
Paralysis
Ablation of ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis.
Parkinson Disease
Changes in Selenoprotein P in Substantia Nigra and Putamen in Parkinson's Disease.
Prioritized brain selenium retention and selenoprotein expression: Nutritional insights into Parkinson's disease.
phospholipid-hydroperoxide glutathione peroxidase deficiency
Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.
Altered hippocampus synaptic function in Selenoprotein P deficient mice.
Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals.
Selenium and Selenoprotein P Deficiency Correlates with Complications and Adverse Outcome After Major Trauma.
Selenoprotein P Deficiency and Risk of Mortality and Rehospitalization in Acute Heart Failure.
Pre-Eclampsia
Evaluation of Glutathione Peroxidase 4 role in Preeclampsia.
Identification of SEPP1 polymorphisms is not a genetic risk factor for preeclampsia in Chinese Han women: A clinical trial and experimental study.
Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood.
Prediabetic State
Serum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis.
Prostatic Neoplasms
6-(3,4-Dihydro-1H-isoquinoline-2-yl)-N-(6-methoxypyridine-2-yl) nicotinamide-26 (DIMN-26) decreases cell proliferation by induction of apoptosis and downregulation of androgen receptor signaling in human prostate cancer cells.
Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk.
Reduced serum selenoprotein P concentrations in German prostate cancer patients.
Selenium and cancer: a story that should not be forgotten-insights from genomics.
Selenium status and risk of prostate cancer in a Danish population.
Selenoprotein gene variants, toenail selenium levels, and risk for advanced prostate cancer.
Selenoprotein P genetic variants and mrna expression, circulating selenium, and prostate cancer risk and survival.
Proteinuria
Effect of selenium-deficient diet on tubular epithelium in normal rats.
Pulmonary Arterial Hypertension
Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target.
Pulmonary Fibrosis
Lipid Peroxidation and GPX4 Inhibition Are Common Causes for Myofibroblast Differentiation and Ferroptosis.
Renal Insufficiency, Chronic
Chronic Kidney Disease Distinctly Affects Relationship Between Selenoprotein P Status and Serum Thyroid Hormone Parameters.
Respiratory Insufficiency
Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.
Seizures
Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease.
Mice lacking selenoprotein p and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures.
Selenium and brain function: a poorly recognized liaison.
Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.
Sepsis
GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis.
New assay for the measurement of selenoprotein P as a sepsis biomarker from serum.
Selenoprotein P neutralizes lipopolysaccharide and participates in hepatic cell endoplasmic reticulum stress response.
Shock, Cardiogenic
Selenoprotein P in Myocardial Infarction with Cardiogenic Shock.
Shock, Septic
Effects of high doses of selenium, as sodium selenite, in septic shock patients a placebo-controlled, randomized, double-blind, multi-center phase II study--selenium and sepsis.
Seleno-enzymes and seleno-compounds: the two faces of selenium.
Selenoprotein P, Rather than Glutathione Peroxidase, as a Potential Marker of Septic Shock and Related Syndromes.
Silicosis
Serum selenium and selenoprotein P in patients with silicosis.
Starvation
Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review.
Molecular characterization of a phospholipid-hydroperoxide glutathione peroxidase from the bumblebee Bombus ignitus.
Molecular characterization of phospholipid hydroperoxide glutathione peroxidases from Hydra vulgaris.
The Potency of Diarylamine Radical-Trapping Antioxidants as Inhibitors of Ferroptosis Underscores the Role of Autoxidation in the Mechanism of Cell Death.
Stroke
Depressed serum selenoprotein P: possible new predicator of increased risk for cerebrovascular events.
The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension.
The metal and metalloprotein profile of human plasma as biomarkers for stroke diagnosis.
Thrombosis
Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice.
Thyroid Diseases
A case-control study of selenoprotein genes polymorphisms and autoimmune thyroid diseases in a Chinese population.
Bone Turnover and Bone Mineral Density Are Independently Related to Selenium Status in Healthy Euthyroid Postmenopausal Women.
Thyroiditis
Selenium and its relationship with selenoprotein P and glutathione peroxidase in children and adolescents with Hashimoto's thyroiditis and hypothyroidism.
Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3.
Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study.
Trypanosomiasis, African
Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.
Virus Diseases
Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.
The Differential Expression of Mitochondrial Function-Associated Proteins and Antioxidant Enzymes during Bovine Herpesvirus 1 Infection: A Potential Mechanism for Virus Infection-Induced Oxidative Mitochondrial Dysfunction.
Vitamin E Deficiency
Minimum Selenium Requirements Increase When Repleting Second-Generation Selenium-Deficient Rats but Are Not Further Altered by Vitamin E Deficiency.
Vitamin E deficiency has different effects on brain and liver phospholipid hydroperoxide glutathione peroxidase activities in the rat.
Wilms Tumor
Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression.