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(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-5,10-dihydrophenazine-1-carboxylate + H2O2
(4)
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(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2
(2)
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(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2
(3)
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(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2
(1)
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(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid + O2
(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid + H2O2
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylic acid + O2
(10aS)-10,10a-dihydrophenazine-1-carboxylic acid + H2O2
(1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid + O2
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid + H2O2
additional information
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(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid + O2
(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid + H2O2
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-
?
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid + O2
(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid + H2O2
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-
?
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid + O2
(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid + H2O2
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-
-
?
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid + O2
(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid + H2O2
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-
?
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylic acid + O2
(10aS)-10,10a-dihydrophenazine-1-carboxylic acid + H2O2
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-
?
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylic acid + O2
(10aS)-10,10a-dihydrophenazine-1-carboxylic acid + H2O2
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-
?
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylic acid + O2
(10aS)-10,10a-dihydrophenazine-1-carboxylic acid + H2O2
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-
?
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylic acid + O2
(10aS)-10,10a-dihydrophenazine-1-carboxylic acid + H2O2
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?
(1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid + O2
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid + H2O2
-
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?
(1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid + O2
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid + H2O2
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-
?
(1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid + O2
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid + H2O2
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?
(1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid + O2
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid + H2O2
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?
additional information
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PhzG is the terminal enzyme in phenazine biosynthesis and its relaxed substrate specificity lets it participate in the generation of both phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid. Competition between flavin-dependent oxidations through PhzG and spontaneous oxidative decarboxylations determines the ratio of phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid and unsubstituted phenazine as the products of phenazine biosynthesis. PhzG synthesizes phenazines in their reduced form
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additional information
?
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PhzG is the terminal enzyme in phenazine biosynthesis and its relaxed substrate specificity lets it participate in the generation of both phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid. Competition between flavin-dependent oxidations through PhzG and spontaneous oxidative decarboxylations determines the ratio of phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid and unsubstituted phenazine as the products of phenazine biosynthesis. PhzG synthesizes phenazines in their reduced form
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additional information
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PhzG reacts with a non-aromatic tricyclic phenazine precursor to catalyze an oxidation/aromatization reaction that yields phenazine-1-carboxylate
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additional information
?
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PhzG is the terminal enzyme in phenazine biosynthesis and its relaxed substrate specificity lets it participate in the generation of both phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid. Competition between flavin-dependent oxidations through PhzG and spontaneous oxidative decarboxylations determines the ratio of phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid and unsubstituted phenazine as the products of phenazine biosynthesis. PhzG synthesizes phenazines in their reduced form
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?
additional information
?
-
PhzG reacts with a non-aromatic tricyclic phenazine precursor to catalyze an oxidation/aromatization reaction that yields phenazine-1-carboxylate
-
-
?
additional information
?
-
PhzG is the terminal enzyme in phenazine biosynthesis and its relaxed substrate specificity lets it participate in the generation of both phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid. Competition between flavin-dependent oxidations through PhzG and spontaneous oxidative decarboxylations determines the ratio of phenazine-1,6-dicarboxylic acid and phenazine-1-carboxylic acid and unsubstituted phenazine as the products of phenazine biosynthesis. PhzG synthesizes phenazines in their reduced form
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?
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Parsons, J.F.; Calabrese, K.; Eisenstein, E.; Ladner, J.E.
Structure of the phenazine biosynthesis enzyme PhzG
Acta Crystallogr. Sect. D
60
2110-2113
2004
Pseudomonas aeruginosa (O69755), Pseudomonas fluorescens (Q51793)
brenda
Xu, N.; Ahuja, E.G.; Janning, P.; Mavrodi, D.V.; Thomashow, L.S.; Blankenfeldt, W.
Trapped intermediates in crystals of the FMN-dependent oxidase PhzG provide insight into the final steps of phenazine biosynthesis
Acta Crystallogr. Sect. D
69
1403-1413
2013
Burkholderia lata (Q396C5), Pseudomonas fluorescens (Q51793), Burkholderia lata ATCC 17760 (Q396C5), Pseudomonas fluorescens 2-79 (Q51793)
brenda
Xie, L.; Xie, L.
Pathway-Centric structure-based multi-target compound screening for anti-virulence drug repurposing
Int. J. Mol. Sci.
20
3504
2019
Pseudomonas aeruginosa (O69755)
brenda
Guo, S.; Wang, Y.; Bilal, M.; Hu, H.; Wang, W.; Zhang, X.
Microbial synthesis of antibacterial phenazine-1,6-dicarboxylic acid and the role of PhzG in Pseudomonas chlororaphis GP72AN
J. Agric. Food Chem.
68
2373-2380
2020
Pseudomonas chlororaphis (E3UVD2), Pseudomonas chlororaphis GP72 (E3UVD2)
brenda
Enzyme Nomenclature
1.10.3.16 dihydrophenazinedicarboxylate synthase
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