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Information on EC 1.1.99.20 - alkan-1-ol dehydrogenase (acceptor)
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1.1.99.20 alkan-1-ol dehydrogenase (acceptor)IUBMB Comments
A quinoprotein. Acts on C3-C16 linear-chain saturated primary alcohols, C4-C7 aldehydes and on non-ionic surfactants containing polyethylene glycol residues, such as Tween 40 and 60, but not on methanol and only very slowly on ethanol. 2,6-Dichloroindophenol can act as acceptor. cf. EC 1.1.99.8 alcohol dehydrogenase (acceptor).
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Word Map
- 1.1.99.20
- dehydrogenases
-
glucose-methanol-choline
- flavin
- flavoproteins
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ensifer
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sphingomonads
- nonylphenols
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dehydrogenation
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stenotrophomonas
- maltophilia
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polypropylene
- industry
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homodimeric
- ppg
- fad
- terrae
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sphingopyxis
The enzyme appears in viruses and cellular organisms
Synonyms
peg-dh, pegdh, npeo-dh, polyethylene glycol dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alkan-1-ol dehydrogenase
alkan-1-ol:acceptor oxidoreductase
dehydrogenase, polyethylene glycol
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polyethylene glycol dehydrogenase
polyethylene glycol dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
primary alcohol + acceptor = aldehyde + reduced acceptor
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
alkan-1-ol:acceptor oxidoreductase
A quinoprotein. Acts on C3-C16 linear-chain saturated primary alcohols, C4-C7 aldehydes and on non-ionic surfactants containing polyethylene glycol residues, such as Tween 40 and 60, but not on methanol and only very slowly on ethanol. 2,6-Dichloroindophenol can act as acceptor. cf. EC 1.1.99.8 alcohol dehydrogenase (acceptor).
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CAS REGISTRY NUMBER
COMMENTARY
75496-55-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-propanol + 2,6-dichloro-phenolindophenol
propanal + reduced 2,6-dichloro-phenolindophenol
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-
-
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r
2-carboxybenzaldehyde + acceptor
2-carboxybenzoic acid + reduced acceptor
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-
-
?
aromatic aldehyde + acceptor + H2O
aromatic carboxylic acid + reduced acceptor
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-
-
?
benzaldehyde + acceptor + H2O
benzoic acid + reduced acceptor
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-
-
?
beta-phenethyl alcohol + acceptor
beta-phenethyl aldehyde + reduced acceptor
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-
-
?
cinnamyl alcohol + acceptor
cinnamyl aldehyde + reduced acceptor
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-
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?
PEG-1000 + 2,6-dichloroindophenol
?
520% activity compared to PEG-mono-4-nonylphenyl ether, averaging 2 ethoxy units
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?
PEG-mono-4-nonylphenyl ether, averaging 10 ethoxy units + 2,6-dichloroindophenol
?
93% activity compared to PEG-mono-4-nonylphenyl ether, averaging 2 ethoxy units
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?
PEG-mono-4-nonylphenyl ether, averaging 2 ethoxy units + 2,6-dichloroindophenol
?
100% activity
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-
?
tetraethylene glycol + 2,6-dichlorophenolindophenol
tetraethylene glycol aldehyde + reduced 2,6-dichlorophenolindophenol
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-
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r
trans-cinnamaldehyde + acceptor
trans-cinnamic acid + reduced acceptor
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-
-
?
vanillin aldehyde + acceptor + H2O
vanillic acid + reduced acceptor
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-
-
?
vannilyl alcohol + acceptor
vannilyl aldehyde + reduced acceptor
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-
-
?
1-tetradecanol + acceptor
n-tetradecanal + reduced acceptor
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-
-
?
acetaldehyde + acceptor + H2O
acetic acid + reduced acceptor
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-
-
?
acetaldehyde + acceptor + H2O
acetic acid + reduced acceptor
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-
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?
aliphatic aldehyde + acceptor + H2O
carboxylic acid + reduced acceptor
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C-3 to C-7
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?
aliphatic aldehyde + acceptor + H2O
carboxylic acid + reduced acceptor
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products of enzymatic reaction from corresponding alcohols, overview: C-4 to C-7
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?
aliphatic aldehyde + acceptor + H2O
carboxylic acid + reduced acceptor
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products of enzymatic reaction from corresponding alcohols, overview: C-4 to C-7
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?
aromatic alcohol + acceptor
aromatic aldehyde + reduced acceptor
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-
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?
aromatic alcohol + acceptor
aromatic aldehyde + reduced acceptor
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?
benzyl alcohol + acceptor
benzaldehyde + reduced acceptor
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benzyl alcohol is the best substrate
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?
detergents + acceptor
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overview: Triton X-100, Tween 40, Tween 60, Brij 35, Epan 410 to 785
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?
detergents + acceptor
?
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overview: Triton X-100, Tween 40, Tween 60, Brij 35, Epan 410 to 785
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?
diols + acceptor
dialdehydes + reduced acceptor
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except ethylene glycol, 1,2-and 1,3-propenediol
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?
diols + acceptor
dialdehydes + reduced acceptor
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except ethylene glycol, 1,2-and 1,3-propenediol
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?
diols + acceptor
dialdehydes + reduced acceptor
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diethylene glycol and triethylene glycol are only poor substrates
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?
diols + acceptor
dialdehydes + reduced acceptor
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diethylene glycol and triethylene glycol are only poor substrates
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?
diols + acceptor
dialdehydes + reduced acceptor
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overview: with primary alcoholic groups
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?
diols + acceptor
dialdehydes + reduced acceptor
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except ethylene glycol, 1,2-and 1,3-propenediol
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?
diols + acceptor
dialdehydes + reduced acceptor
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diethylene glycol and triethylene glycol are only poor substrates
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?
ethanol + acceptor
acetaldehyde + reduced acceptor
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?
glycidol + acceptor
2,3-epoxypropion aldehyde + reduced acceptor
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-
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?
glycidol + acceptor
2,3-epoxypropion aldehyde + reduced acceptor
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?
heptanal + acceptor + H2O
heptanoic acid + reduced acceptor
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?
PEG-4000 + acceptor
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enzyme is constitutively expressed
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?
PEG-4000 + acceptor
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enzyme is constitutively expressed
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?
pentanal + acceptor + H2O
pentanoic acid + reduced acceptor
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?
polyethylene glycol + acceptor
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constitutive quinoprotein enzyme, enzyme of Flavobacterium sp. No.203 inductive
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?
polyethylene glycol + acceptor
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ubiquinone possible physiological acceptor
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?
polyethylene glycol + acceptor
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first and main step in aerobic PEG-metabolism
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?
polyethylene glycol + acceptor
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ubiquinone possible physiological acceptor
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?
polyethylene glycol + acceptor
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first and main step in aerobic PEG-metabolism
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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C-3 to C-12
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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ethanol is only a poor substrate
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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methanol, glycerol, secondary alcohols and sugar alcohols are no substrates
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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methanol, glycerol, secondary alcohols and sugar alcohols are no substrates
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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coenzyme Q1 and Q2 can act as acceptors
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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coenzyme Q1 and Q2 can act as acceptors
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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overview: C-2 to C-16
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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ethanol is only a poor substrate
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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methanol, glycerol, secondary alcohols and sugar alcohols are no substrates
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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2,6-dichlorophenolindophenol is the acceptor in vitro
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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coenzyme Q1 and Q2 can act as acceptors
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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overview: C-2 to C-16
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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?
primary alcohol + acceptor
aldehyde + reduced acceptor
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?
propanal + acceptor + H2O
propionic acid + reduced acceptor
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?
solketal + acceptor
2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde + reduced acceptor
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?
solketal + acceptor
2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde + reduced acceptor
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?
tetraethylene glycol + acceptor
tetraethylene glycol aldehyde + reduced acceptor
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?
tetraethylene glycol + acceptor
tetraethylene glycol aldehyde + reduced acceptor
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?
tetraethylene glycol + acceptor
tetraethylene glycol aldehyde + reduced acceptor
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a 2,4-dinitrophenylhydrazine-positive compound from tetraethylene glycol, tetrazolium blue, dimethylbenzaldehyde, 3-methyl-2-benzothiazolinonehydrazone hydrochloride and p-nitrophenylhydrazine are also present in the reaction mixture
?
tetraethylene glycol + acceptor
tetraethylene glycol aldehyde + reduced acceptor
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?
tetraethylene glycol + acceptor
tetraethylene glycol aldehyde + reduced acceptor
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a 2,4-dinitrophenylhydrazine-positive compound from tetraethylene glycol, tetrazolium blue, dimethylbenzaldehyde, 3-methyl-2-benzothiazolinonehydrazone hydrochloride and p-nitrophenylhydrazine are also present in the reaction mixture
?
tetraethylene glycol + acceptor
tetraethylene glycol aldehyde + reduced acceptor
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?
tetraethylene glycol + acceptor
tetraethylene glycol aldehyde + reduced acceptor
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?
additional information
?
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the enzyme shows no activity toward ethylene glycol, glycerol, secondary alcohols and sugar alcohols
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?
additional information
?
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the enzyme shows no activity toward diglycolic acid, tetraethylene glycol dicarboxylic acid, methoxyacetic acid or ethoxyacetic acid
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?
additional information
?
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the enzyme shows no activity toward diglycolic acid, tetraethylene glycol dicarboxylic acid, methoxyacetic acid or ethoxyacetic acid
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?
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