Any feedback?
Information on EC 1.1.1.B40 - 11beta-hydroxysteroid dehydrogenase (NAD+)
for references in articles please use BRENDA:EC1.1.1.B40preliminary BRENDA-supplied EC number
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+)Specify your search results
Word Map
- 1.1.1.B40
- glucocorticoid
-
mineralocorticoid
- cortisone
- aldosterone
- hypertension
- adrenal
- 11-dehydrocorticosterone
- dexamethasone
- urinary
- fetal
- carbenoxolone
-
glycyrrhetinic
- 11beta-hsds
-
beta-hsd1
- nadp
- acth
- renin
- hypokalemia
- spironolactone
- tetrahydrocortisol
-
cortisol-cortisone
-
liquorice
- thf
-
adrenalectomized
-
cushing
-
11-keto
-
beta-reductase
-
glycyrrhizic
-
hypopituitary
- medicine
-
3hcorticosterone
-
prereceptor
- pharmacology
-
11-beta-hydroxysteroid
-
feto-placental
-
low-renin
- drug development
-
11-dehydro
-
oxo-reductase
The enzyme appears in viruses and cellular organisms
Synonyms
11 beta-hydroxysteroid dehydrogenase, 11 beta-hydroxysteroid dehydrogenase type 2, 11beta-hsd type 2, 11beta-ohsd, 11beta-hsd 2, 11-beta hydroxysteroid dehydrogenase type 2, type 2 11beta-hydroxysteroid dehydrogenase, 11beta hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type-2, nad(+)-dependent 11beta-dehydrogenase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
11beta-HSD
11beta-HSD1
11beta-HSD2
11beta-hydroxysteroid dehydrogenase 2
11beta-hydroxysteroid dehydrogenase type 1
11beta-hydroxysteroid dehydrogenase type 2
11betaHSD2
corticosteroid 11-beta-dehydrogenase isozyme 1
11beta-HSD2
-
-
11beta-hydroxysteroid dehydrogenase 2
-
-
11beta-hydroxysteroid dehydrogenase type 2
-
-
11beta-hydroxysteroid dehydrogenase type 2
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
-
-
-
-
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
substrate binding site structure, reaction mechanism involving Lys187 and Tyr183, active site structure involving a S-Y-K catalytic triad
-
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
-
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
-
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
-
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
11beta-hydroxysteroid:NAD+ 11-oxidoreductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
1beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, no reductase activity in aldosterone-sensitive collecting duct
-
-
ir
2 7-oxocholesterol + 2 NADPH + 2 H+
7beta-hydroxycholesterol + 7alpha-hydroxycholesterol + 2 NADP+
isozyme 11beta-HSD1, stereospecific reaction
-
-
?
11-dehydrocorticosterone + beta-NADPH
corticosterone + beta-NADP+
low activity
-
-
r
11-dehydrocorticosterone + beta-NADPH
corticosterone + beta-NADP+
-
higher activity
-
-
r
11-dehydrocorticosterone + beta-NADPH
corticosterone + beta-NADP+
-
higher activity
-
-
r
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1, low activity
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
-
i.e. cortisol
i.e. cortisone
?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
-
i.e. cortisol
i.e. cortisone
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone
-
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, clear but not exclusive preference for NAD+, only oxidative activity
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, significant higher rate of conversion for 11-beta-HSD2 than for 11-beta-HSD1
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone
-
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, no enzyme activity in reverse reaction direction
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
i.e. corticosterone
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
i.e. corticosterone
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
Ovis aries aries
-
isoform 11beta-HSD2
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
Ovis aries aries
-
i.e. corticosterone
-
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
-
i.e. cortisone
i.e. cortisol
ir
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
-
important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids
i.e. cortisol
ir
7-oxocholesterol + NADPH + H+
7beta-hydroxycholesterol + NADP+
-
isozyme 11beta-HSD1, stereospecific reaction, very low activity
-
-
?
7-oxocholesterol + NADPH + H+
7beta-hydroxycholesterol + NADP+
isozyme 11beta-HSD1, stereospecific reaction, very low activity
-
-
?
7-oxocholesterol + NADPH + H+
7beta-hydroxycholesterol + NADP+
isozyme 11beta-HSD1, stereospecific reaction
-
-
?
7-oxocholesterol + NADPH + H+
7beta-hydroxycholesterol + NADP+
-
isozyme 11beta-HSD1, stereospecific reaction
-
-
?
7-oxocholesterol + NADPH + H+
7beta-hydroxycholesterol + NADP+
-
isozyme 11beta-HSD1, stereospecific reaction
-
-
?
corticosterone + beta-NAD+
11-dehydrocorticosterone + beta-NADH
-
-
-
-
r
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
ir
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
?
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
ir
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
isozyme 11beta-HSD2
-
-
?
cortisol + NAD+
cortisone + NADH
-
oxidase that inactivates glucocorticoids to their 11-oxo derivatives
-
-
?
cortisol + NAD+
cortisone + NADH
-
inactivation of the biologically active glucocorticoid
-
-
r
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 catalyzes the oxidative reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2, inactivation of cortisol, which interacts with the mineralocorticoid receptor, isozyme 11beta-HSD2 inhibition leads to stimulation of sodium and water reabsorption and to an increase of the intravascular volume that suppresses renin and secondarily an increase of blood pressure
-
-
?
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 catalyzes the reverse reaction 11beta-HSD1 with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 catalyzes the reverse reaction of 11-beta-HSD1 with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
-
-
ir
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 highly prefers the oxidation of cortisol
-
-
r
cortisol + NAD+
cortisone + NADH
-
isozyme 11beta-HSD2 is involved in inactivation of glucocorticoids, forskolin is involved in regulation of isozyme 11beta-HSD2 via intracellular cAMP
-
-
ir
cortisol + NAD+
cortisone + NADH
-
levels of cortisol oxidation are comparable in the presence of either NADP+ or NAD+
-
-
?
cortisol + NAD+
cortisone + NADH
isozyme 11beta-HSD2 catalyzes the reverse reaction of 11beta-HSD1 with cofactor NAD+
-
-
ir
cortisone + beta-NADPH
cortisol + beta-NADP+
-
higher activity
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1, activation
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1, low activity
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1, activation
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1, high activity
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1, activation
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1, preferred substrate, high activity
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1, activation
-
-
?
cortisone + NADPH + H+
cortisol + NADP+
isozyme 11beta-HSD1, high activity
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
-
isozyme 11beta-HSD1, activation
-
-
?
dexamethasone + NAD+
11-dehydromethasone + NADH
-
isoform 11beta-HSD2
-
ir
dexamethasone + NAD+
11-dehydromethasone + NADH
-
isoform 11-beta-HSD2 shows significantly higher rate of conversion than isoform 11-betaHSD1
-
-
ir
additional information
?
-
the enzyme plays a role in spermatogenesis
-
-
?
additional information
?
-
-
enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview
-
-
?
additional information
?
-
-
proinflammatory cytokines inhibit placental isozyme 11beta-HSD2 activity through Ca2+ and cAMP pathways, overview
-
-
?
additional information
?
-
-
effects of hypertension on cardiac steroid metabolism, overview
-
-
?
additional information
?
-
-
estradiol has a regulatory function on the isozymes in the liver, isozyme 11beta-HSD1 expression is about 30% reduced in castrated male rats, while expression of isozyme 11beta-HSD2 is increased, overview
-
-
?
additional information
?
-
the enzyme plays a role in control of cortisol and spermatogenesis
-
-
?
additional information
?
-
-
physiological role of 11beta-hydroxysteroid dehydrogenase in limiting any local actions of glucocorticoids within the reproductive tissues
-
-
?
additional information
?
-
-
maximal rates for NADP+-dependent cortisol oxidation are 7.4-28.5fold greater than the Vmax for NADPH-dependent reduction of cortisone, and are comparable with the rates of NAD+-dependent cortisol metabolism
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
1beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, no reductase activity in aldosterone-sensitive collecting duct
-
-
ir
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
-
isozyme 11beta-HSD1
-
-
?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
-
i.e. cortisol
i.e. cortisone
?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
-
i.e. cortisol
i.e. cortisone
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone
-
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, clear but not exclusive preference for NAD+, only oxidative activity
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, significant higher rate of conversion for 11-beta-HSD2 than for 11-beta-HSD1
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone
-
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
i.e. corticosterone, no enzyme activity in reverse reaction direction
-
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
i.e. corticosterone
-
ir
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
-
i.e. corticosterone
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
Ovis aries aries
-
isoform 11beta-HSD2
-
r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
Ovis aries aries
-
i.e. corticosterone
-
r
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
-
i.e. cortisone
i.e. cortisol
ir
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
-
important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids
i.e. cortisol
ir
corticosterone + beta-NAD+
11-dehydrocorticosterone + beta-NADH
-
-
-
-
r
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
ir
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
?
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
-
-
-
ir
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
-
isozyme 11beta-HSD2
-
-
?
cortisol + beta-NAD+
cortisone + beta-NADH