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Information on EC 1.1.1.B20 - meso-2,3-butandiol dehydrogenase
for references in articles please use BRENDA:EC1.1.1.B20preliminary BRENDA-supplied EC number
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EC Tree
1.1.1.B20 meso-2,3-butandiol dehydrogenaseSpecify your search results
Word Map
- 1.1.1.B20
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klebsiella
- diacetyl
- pneumoniae
-
fed-batch
-
nadh-dependent
-
2s,3s-2,3-butanediol
-
enterobacter
- synthesis
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serratia
- marcescens
- cloacae
- hydrolysate
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acetobacter
-
biofuels
- polymyxa
- lactis
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byproduct
- acetolactate
- 1,4-butanediol
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bioconversion
- aerogenes
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racemic
-
refolding
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
2,3-bd dehydrogenase, smbdh, 2,3-butanediol dehydrogenases, meso-2,3-bdh, meso-bd, meso-2,3-bd dehydrogenase, nad(h)-dependent meso-2,3-bdh, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(2R,3R)-2,3-butanediol dehydrogenase
2,3-BD dehydrogenase
2,3-butanediol dehydrogenase
2,3-butanediol dehydrogenases
BDH
BdhA
budC
butanediol dehydrogenase
CG-BDH
Cgl2674
mbdh
meso-2,3-BD dehydrogenase
meso-2,3-BDH
meso-2,3-butanediol dehydrogenase
meso-acetoin reductase
meso-BDH
NAD(H)-dependent meso-2,3-BDH
NAD(H)-dependent meso-2,3-butanediol dehydrogenase
PF-BDH
PF1960
PT-BDH
R,R-2,3-butanediol dehydrogenase/meso-2,3-butanediol dehydrogenase/diacetyl reductase
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SmBdh
additional information
(2R,3R)-2,3-butanediol dehydrogenase
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(2R,3S)-butane-2,3-diol + NAD+ = acetoin + NADH + H+
catalytic triad is formed by residues Ser139, Tyr 152, and Lys156
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(2R,3S)-butane-2,3-diol + NAD+ = acetoin + NADH + H+
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SYSTEMATIC NAME
IUBMB Comments
(2R,3S)-butane-2,3-diol:NAD+ oxidoreductase
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2R,3R)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2S,3S)-2,3-butanediol + NAD+
(3S)-acetoin + NADH
-
(2S,3S)-2,3-butanediol is a poor substrate
-
-
?
(R,R)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
stereoselective interconversion
-
-
r
2 (R,S)-acetoin + 2 NADPH + 2 H+
(2S,3S)-2,3-butanediol + meso-2,3-butanediol + NADP+
-
-
Ara1p is selective toward the acetoin carbonyl group, leading to an S-alcohol
-
r
2 acetoin + 2 NADH + 2 H+
(2S,3S)-2,3-butanediol + meso-2,3-butanediol + 2 NAD+
-
racemic mixture of (3S/3R)-acetoin
-
-
r
2,3-hexanedione + NADH + H+
(S)-3-hydroxy-2-hexanone + NAD+
-
-
-
?
2,3-pentanedione + NADH + H+
(3S)-3-hydroxy-2-pentanone + NAD+
-
-
-
?
diacetyl + 2 NADH + 2 H+
(2R,3R)-butane-2,3-diol + 2 NAD+
-
-
-
r
meso-2,3-butanediol + NADP+
(R)-acetoin + NADPH + H+
very low activity
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
?
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
slightly preferred substrate
-
-
?
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
preferred substrate
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
?
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
?
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
meso-butane-2,3-diol
-
-
?
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
stereoselective interconversion
-
-
?
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3R)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
r
(2R,3S)-butane-2,3-diol + NAD+
(3S)-acetoin + NADH + H+
-
-
-
r
(2S,3S)-2,3-butanediol + NAD+
(3S)-acetoin + NADH + H+
low activity
-
-
r
(2S,3S)-2,3-butanediol + NAD+
(3S)-acetoin + NADH + H+
low activity
-
-
r
(3R)-acetoin + NADH + H+
meso-2,3-butanediol + NAD+
-
-
-
r
(3R)-acetoin + NADH + H+
meso-2,3-butanediol + NAD+
-
low activity in vivo
-
-
r
(3S)-acetoin + NADH + H+
(2S,3S)-2,3-butanediol + NAD+
at pH 9.0
-
-
r
(3S)-acetoin + NADH + H+
(2S,3S)-2,3-butanediol + NAD+
at pH 9.0
-
-
r
(R)-acetoin + NADH + H+
meso-2,3-butanediol + NAD+
preferred reaction direction
-
-
r
(R)-acetoin + NADH + H+
meso-2,3-butanediol + NAD+
-
-
-
r
(R)-acetoin + NADH + H+
meso-2,3-butanediol + NAD+
preferred reaction direction
-
-
r
(R)-acetoin + NADPH + H+
meso-2,3-butanediol + NADP+
very low activity
-
-
r
(R)-acetoin + NADPH + H+
meso-2,3-butanediol + NADP+
very low activity
-
-
r
1,2-cyclohexanedione + NADH + H+
(S,S)-1,2-cyclohexanediol + NAD+
-
-
-
?
1,2-cyclohexanedione + NADH + H+
(S,S)-1,2-cyclohexanediol + NAD+
Serratia marcescens CECT 977
-
-
-
?
1-phenyl-1,2-propanedione + NADH + H+
(S)-2-hydroxy-1-phenylpropan-1-one + NAD+
-
-
-
?
1-phenyl-1,2-propanedione + NADH + H+
(S)-2-hydroxy-1-phenylpropan-1-one + NAD+
Serratia marcescens CECT 977
-
-
-
?
4-methyl-2-pentanone + NADH + H+
4-methyl-2-pentanol + NAD+
-
low activity
-
-
r
4-methyl-2-pentanone + NADH + H+
4-methyl-2-pentanol + NAD+
-
low activity
-
-
r
acetoin + NADH + H+
meso-2,3-butanediol + NAD+
racemic mixture of (3S/3R)-acetoin
-
-
r
acetoin + NADH + H+
meso-2,3-butanediol + NAD+
racemic mixture of (3S/3R)-acetoin
-
-
r
meso-2,3-butanediol + NAD+
(R)-acetoin + NADH + H+
-