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IUBMB CommentsRequires K+ or NH4+ and Mn2+ or Co2+; also acts on (R)-malate.
The enzyme appears in viruses and cellular organisms
Synonyms
dimethylmalate dehydrogenase,
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beta,beta-dimethylmalate dehydrogenase
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dehydrogenase, dimethylmalate
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(R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH + H+
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(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)
Requires K+ or NH4+ and Mn2+ or Co2+; also acts on (R)-malate.
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(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
3-(n-propyl)malate + NAD+
2-oxopentanoate + CO2 + NADH
D-malate + NAD+
pyruvate + CO2 + NADH
(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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r
(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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r
3-(n-propyl)malate + NAD+
2-oxopentanoate + CO2 + NADH
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3-(n-propyl)malate + NAD+
2-oxopentanoate + CO2 + NADH
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D-malate + NAD+
pyruvate + CO2 + NADH
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D-malate + NAD+
pyruvate + CO2 + NADH
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D-malate + NAD+
pyruvate + CO2 + NADH
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D-malate + NAD+
pyruvate + CO2 + NADH
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(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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r
(R)-3,3-dimethylmalate + NAD+
3-methyl-2-oxobutanoate + CO2 + NADH
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r
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NAD+
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Co2+
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Mn2+ or Co2+ required
Mn2+
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Mn2+ or Co2+ required
NH4+
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K+ or NH4+ required
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additional information
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fairly stable against SH-group reactants
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0.15 - 0.2
3,3-dimethyl-D-malate
0.33
3-(n-Propyl)malate
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0.15 - 0.2
3,3-dimethyl-D-malate
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0.15 - 0.2
3,3-dimethyl-D-malate
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8.9 - 11
D-malate
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0.27
NAD+
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8 - 8.5
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substrates 3,3-dimethylmalate + NAD+
8.4
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substrates 3,3-dimethylmalate + NAD+
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brenda
P-2
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brenda
P-2
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brenda
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136000
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ultracentrifugation
34000
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4 * 34000, SDS-PAGE
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tetramer
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4 * 34000, SDS-PAGE
tetramer
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4 * 34000, SDS-PAGE
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tetramer
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4 * 34000, SDS-PAGE
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60
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5 min, 40% loss of activity
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Lähdesmäki, M.; Mäntsälä, P.
Comparison of D-malate and beta, beta-dimethylmalate dehydrogenases from Pseudomonas fluorescens UK-1
Biochim. Biophys. Acta
613
266-274
1980
Pseudomonas fluorescens
brenda
Mäntsälä, P.
Purification of pantoate and dimethylmalate dehydrogenase from Pseudomonas fluorescens UK-1
Biochim. Biophys. Acta
526
25-33
1978
Pseudomonas fluorescens
brenda
Magee, P.T.; Snell, E.E.
The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate
Biochemistry
5
409-416
1966
Pseudomonas sp., Pseudomonas sp. P-2
brenda
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1.1.1.84 dimethylmalate dehydrogenase
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