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Information on EC 1.1.1.73 - octanol dehydrogenase
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EC Tree
1.1.1.73 octanol dehydrogenaseIUBMB Comments
Acts, less rapidly, on other long-chain alcohols.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
octanol dehydrogenase, (r)-2-octanol dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-octanol dehydrogenase
-
-
-
-
ODH
ODH
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
octan-1-ol + NAD+ = octanal + NADH + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
octanol:NAD+ oxidoreductase
Acts, less rapidly, on other long-chain alcohols.
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CAS REGISTRY NUMBER
COMMENTARY
9031-31-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1R)-1-phenylethan-1-ol + NAD+
phenylacetaldehyde + NADH + H+
255% activity compared to (R)-octan-2-ol
-
-
?
(1S)-1-phenylethan-1-ol + NAD+
phenylacetaldehyde + NADH + H+
1.8% activity compared to (R)-octan-2-ol
-
-
?
(2R)-butan-2-ol + NAD+
butan-2-one + NADH + H+
49.3% activity compared to (R)-octan-2-ol
-
-
?
(2R)-hexan-2-ol + NAD+
hexan-2-one + NADH + H+
54.1% activity compared to (R)-octan-2-ol
-
-
?
(2S)-butan-2-ol + NAD+
butan-2-one + NADH + H+
7.3% activity compared to (R)-octan-2-ol
-
-
?
(RS)-octan-2-ol + NAD+
octan-2-one + NADH + H+
77.8% activity compared to (R)-octan-2-ol
-
-
?
(S)-octan-2-ol + NAD+
octan-2-one + NADH + H+
4.7% activity compared to (R)-octan-2-ol
-
-
?
1-phenoxypropan-2-ol + NAD+
1-phenoxypropan-2-one + NADH + H+ +
15.5% activity compared to (R)-octan-2-ol
-
-
?
1-phenoxypropan-2-one + NADH + H+
1-phenoxypropan-2-ol + NAD+
54.2% activity compared to ethyl 4-chloroacetoacetate
-
-
?
1-phenylethan-1-one + NADH + H+
1-phenylethan-1-ol + NAD+
45.3% activity compared to ethyl 4-chloroacetoacetate
-
-
?
2-bromo-1-cyclopropylethan-1-one + NADH + H+
2-bromo-1-cyclopropylethan-1-ol + NAD+
54.3% activity compared to ethyl 4-chloroacetoacetate
-
-
?
2-chloro-1-(3-chlorophenyl)ethan-1-one + NADH + H+
2-chloro-1-(3-chlorophenyl)ethan-1-ol + NAD+
64.7% activity compared to ethyl 4-chloroacetoacetate
-
-
?
2-chloro-1-(4-fluorophenyl)ethan-1-one + NADH + H+
2-chloro-1-(4-fluorophenyl)ethan-1-ol + NAD+
89.2% activity compared to ethyl 4-chloroacetoacetate
-
-
?
2-chloro-1-(pyridin-3-yl)ethan-1-one + NADH + H+
2-chloro-1-(pyridin-3-yl)ethan-1-ol + NAD+
9.4% activity compared to ethyl 4-chloroacetoacetate
-
-
?
2-chloro-1-phenylethan-1-one + NADH + H+
2-chloro-1-phenylethan-1-ol + NAD+
52.6% activity compared to ethyl 4-chloroacetoacetate
-
-
?
3-acetyloxolan-2-one + NADH + H+
3-acetyloxolan-2-ol + NAD+
12.7% activity compared to ethyl 4-chloroacetoacetate
-
-
?
5-chloropentan-2-one + NADH + H+
5-chloropentan-2-ol + NAD+
108% activity compared to ethyl 4-chloroacetoacetate
-
-
?
butan-2-one + NADH + H+
butan-2-ol + NAD+
8.0% activity compared to ethyl 4-chloroacetoacetate
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
0.7% activity compared to (R)-octan-2-ol
-
-
?
ethyl (3R)-3-hydroxybutanoate + NAD+
ethyl 3-oxobutanoate + NADH + H+
41.1% activity compared to (R)-octan-2-ol
-
-
?
ethyl (3S)-3-hydroxybutanoate + NAD+
ethyl 3-oxobutanoate + NADH + H+
1.0% activity compared to (R)-octan-2-ol
-
-
?
ethyl (3S)-4-chloro-3-hydroxybutanoate + NAD+
ethyl 4-chloro-3-oxobutanoate + NADH + H+
2.2% activity compared to (R)-octan-2-ol
-
-
?
ethyl 2-chloro-3-oxobutanoate + NADH + H+
ethyl 2-chloro-3-oxobutanoate + NAD+
571% activity compared to ethyl 4-chloroacetoacetate
-
-
?
ethyl 3-oxobutanoate + NADH + H+
ethyl 3-hydroxybutanoate + NAD+
105.8% activity compared to ethyl 4-chloroacetoacetate
-
-
?
farnesol + NAD+
3,7,11-trimethyl-2,6,10-dodecatrien-1-al + NADH
Drosophila sp. (in: flies)
-
-
-
-
?
octan-1-ol + NAD+
octanal + NADH + H+
1.7% activity compared to (R)-octan-2-ol
-
-
?
octan-2-one + NADH + H+
octan-2-ol + NAD+
31.2% activity compared to ethyl 4-chloroacetoacetate
-
-
?
propan-2-ol + NAD+
propan-2-one + NADH + H+
6.8% activity compared to (R)-octan-2-ol
-
-
?
propan-2-one + NADH + H+
propan-2-ol + NAD+
1.8% activity compared to ethyl 4-chloroacetoacetate
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
not inhibited by Co2+, Zn2+, K+, Ni2+, Ba2+, NH2OH, and quercetin
-
additional information
-
not inhibited by Co2+, Zn2+, K+, Ni2+, Ba2+, NH2OH, and quercetin
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Malaria
Genetic analysis of two enzyme polymorphisms in a malaria vector mosquito: octanol dehydrogenase and acid phosphatase in Anopheles culicifacies Giles.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ADHX_DROME
379
0
40389
Swiss-Prot
other Location (Reliability: 2)
Q6A4C4_DROSU
227
0
24165
TrEMBL
other Location (Reliability: 2)
Q6A4C6_DROSU
227
0
24161
TrEMBL
other Location (Reliability: 2)
Q6A4C7_DROSU
227
0
24258
TrEMBL
other Location (Reliability: 2)
Q6A4E6_DROSU
227
0
24131
TrEMBL
other Location (Reliability: 1)
A0A139B7P0_9BIFI
348
0
36848
TrEMBL
-
Q6A4H7_DROSU
227
0
24121
TrEMBL
other Location (Reliability: 2)
Q6A4G7_DROSU
227
0
24110
TrEMBL
other Location (Reliability: 2)
Q6A4E1_DROSU
227
0
24117
TrEMBL
other Location (Reliability: 1)
Q6A4G0_DROSU
227
0
24125
TrEMBL
other Location (Reliability: 2)
D2QAA8_BIFDB
Bifidobacterium dentium (strain ATCC 27534 / DSM 20436 / JCM 1195 / Bd1)
348
0
36920
TrEMBL
-
Q6A4H0_DROSU
227
0
24135
TrEMBL
other Location (Reliability: 2)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
101500
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate precipitation, phenyl-Toyopearl column chromatography, HiTrap Blue column chromatography, DEAE-Sepharose column chromatography, and Superdex 200 gel filtration
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Joslyn, D.J.; Boucias, D.G.
Isozyme differentiation among three pathotypes of the entomogenous fungus Nomuraea rileyi
Can. J. Microbiol.
27
364-366
1981
Metarhizium rileyi
brenda
Dickinson, W.J.
Tissue specificity of enzyme expression regulated by diffusible factors: evidence in Drosophila hybrids
Science
207
995-997
1980
Drosophila formella, Drosophila grimshawi, Drosophila orthofascia
brenda
Coyne, J.A.; Felton, A.A.
Genic heterogeneity at two alcohol dehydrogenase loci in Drosophila Pseudoobscura and Drosophila Persimilis
Genetics
87
285-304
1977
Drosophila persimilis, Drosophila pseudoobscura
brenda
Sene, F.M.; Carson, H.L.
Genetic variation in Hawaiian Drosophila. IV. Allozymic similarity between D. silvestris and D. heteroneura from the island of Hawaii
Genetics
86
187-198
1977
Drosophila heteroneura, Drosophila silvestris
brenda
Sieber, F.; Fox, D.J.; Ursprung, H.
Properties of octanol dehydrogenase from Drosophila
FEBS Lett.
26
274-276
1972
Drosophila sp. (in: flies)
brenda
Roche, B.; Azoulay, E.
Regulation of the alcohol dehydrogenases Saccharomyces cerevisiae
Eur. J. Biochem.
8
426-434
1969
Saccharomyces cerevisiae
brenda
Yamamoto, H.; Kudoh, M.
Novel chiral tool, (R)-2-octanol dehydrogenase, from Pichia finlandica: Purification, gene cloning, and application for optically active alpha-haloalcohols
Appl. Microbiol. Biotechnol.
97
8087-8096
2013
Ogataea wickerhamii (A0JC04), Ogataea wickerhamii
brenda
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