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IUBMB Comments The enzyme, characterized from alphaproteobacteria, is involved in a D -sulfoquinovose degradation pathway.
The enzyme appears in viruses and cellular organisms
Synonyms Atu3278 , D-glucose 6-dehydrogenase, smoB , squF , more
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D-glucose 6-dehydrogenase
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Atu3278
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smoB
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squF
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D-glucose + NADP+ = 6-dehydro-D-glucose + NADPH + H+
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MetaCyc
sulfoquinovose degradation IV
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D-glucose:NADP+ 6-oxidoreductase
The enzyme, characterized from alphaproteobacteria, is involved in a D-sulfoquinovose degradation pathway.
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6-dehydro-D-glucose + NADPH + H+
D-glucose + NADP+
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Substrates: - Products: -
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D-glucose + NADP+
6-dehydro-D-glucose + NADPH + H+
D-glucose + NADP+
6-dehydro-D-glucose + NADPH + H+
Substrates: - Products: -
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D-glucose + NADP+
6-dehydro-D-glucose + NADPH + H+
Substrates: - Products: -
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D-glucose + NADP+
6-dehydro-D-glucose + NADPH + H+
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Substrates: - Products: -
r
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D-glucose + NADP+
6-dehydro-D-glucose + NADPH + H+
D-glucose + NADP+
6-dehydro-D-glucose + NADPH + H+
Substrates: - Products: -
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D-glucose + NADP+
6-dehydro-D-glucose + NADPH + H+
Substrates: - Products: -
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NADPH
binds to SmoB with Kd of about 2 microM
additional information
NAD+ does not support the reaction, no binding is observed for NADH
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
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evolution
the sulfoquinovose monooxygenase pathway is distributed across Alpha- and Betaproteobacteria and is especially prevalent within the Rhizobiales order
evolution
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the sulfoquinovose monooxygenase pathway is distributed across Alpha- and Betaproteobacteria and is especially prevalent within the Rhizobiales order
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physiological function
enzyme is part of a pathway for sulfoquinovose degradation. The NAD(P)H-dependent oxidoreductase reduces the 6-oxo-glucose to glucose, enabling entry into primary metabolic pathways
physiological function
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in Novosphingobium aromaticivorans, sulfoquinovose degradation involves oxygenolytic C-S cleavage by flavin-dependent alkanesulfonate monooxygenase SquD that catalyzes sulfoquinovose cleavage into sulfite and 6-dehydro-D-glucose. SquF is an NAD(P)-dependent D-glucose 6-dehydrogenase
physiological function
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enzyme is part of a pathway for sulfoquinovose degradation. The NAD(P)H-dependent oxidoreductase reduces the 6-oxo-glucose to glucose, enabling entry into primary metabolic pathways
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A9CEY6_AGRFC
Agrobacterium fabrum (strain C58 / ATCC 33970)
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31912
TrEMBL
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A9CEY6_AGRFC
297
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31912
TrEMBL
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trimer
crystallization data
trimer
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crystallization data
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in complex with NADPH and as ternary product complex by soaking crystals with D-glucose, to 1.5 A resolution. SmoB is an (alpha/beta)8 TIM barrel fold with a C-terminal cofactor binding site. Glucose interacts with residues Arg152 and Lys120 as well as His151 and Tyr76 within the conserved catalytic tetrad His/Tyr/Lys/Asp. SmoB exists as a compact trimer
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Liu, J.; Wei, Y.; Ma, K.; An, J.; Liu, X.; Liu, Y.; Ang, E.; Zhao, H.; Zhang, Y.
Mechanistically diverse pathways for sulfoquinovose degradation in bacteria
ACS Catal.
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14740-14750
2021
Novosphingobium aromaticivorans
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Sharma, M.; Lingford, J.P.; Petricevic, M.; Snow, A.J.D.; Zhang, Y.; Jaerva, M.A.; Mui, J.W.; Scott, N.E.; Saunders, E.C.; Mao, R.; Epa, R.; da Silva, B.M.; Pires, D.E.V.; Ascher, D.B.; McConville, M.J.; Davies, G.J.; Williams, S.J.; Goddard-Borger, E.D.
Oxidative desulfurization pathway for complete catabolism of sulfoquinovose by bacteria
Proc. Natl. Acad. Sci. USA
119
e2116022119
2022
Agrobacterium fabrum (A9CEY6), Agrobacterium fabrum ATCC 33970 (A9CEY6)
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