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Information on EC 1.1.1.43 - phosphogluconate 2-dehydrogenase
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EC Tree
1.1.1.43 phosphogluconate 2-dehydrogenaseSpecify your search results
Word Map
- 1.1.1.43
- glucose-6-phosphate
- pentose
-
malic
- phosphoglucomutase
- malate
- dehydrogenases
- erythrocyte
- hexokinase
- isocitrate
- nadp
- hexose
-
phosphofructokinase
-
lipogenic
- esterase
-
1.1.1.44
- adenylate
-
shunt
- haptoglobin
- gpi
- leishmania
-
nadp-dependent
-
lipogenesis
- transketolase
- 6-aminonicotinamide
- ribulose-5-phosphate
- phosphoglucoisomerase
- tropica
- g-6-pdh
-
glucosephosphate
- utilis
-
nadph-generating
-
monomorphic
-
nadp-malic
-
pentose-phosphate
-
entner-doudoroff
-
allozyme
-
phosphoglucose
-
nadp-isocitrate
- ribulose
-
zymodemes
- transaldolase
-
meal-fed
-
phosphohexose
-
atp-citrate
-
nadph-producing
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
6-phosphogluconate dehydrogenase, 6pgdh, phosphogluconate dehydrogenase, 6-pgdh, 6-phosphogluconic dehydrogenase, 6-phosphogluconate-dehydrogenase, 6-pgdase, gluconate 6-phosphate dehydrogenase, 6pgad, 2-keto-6-phosphogluconate reductase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
2-keto-6-phosphogluconate reductase
-
-
-
-
6-phosphogluconate dehydrogenase
6-phosphogluconate dehydrogenase (NAD)
-
-
-
-
6-phosphogluconate-dehydrogenase
6-phosphogluconic dehydrogenase
-
-
-
-
6PGD
6PGDH
gluconate 6-phosphate dehydrogenase
-
-
-
-
phosphogluconate dehydrogenase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
6-phospho-D-gluconate + NAD(P)+ = 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
-
-
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SYSTEMATIC NAME
IUBMB Comments
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase
-
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CAS REGISTRY NUMBER
COMMENTARY
9001-82-5
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+
-
-
-
-
?
6-phosphono-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
second step of hexose monophosphate shunt, i.e. HMS
-
-
?
D-glucose-6-phosphate + NADP+
2-dehydro-6-phospho-D-glucose + NADPH
-
NADP-specific enzyme, 4% of the activity with 6-phosphogluconate
-
-
?
6-phospho-2-dehydro-D-gluconate + NAD(P)H
6-phospho-D-gluconate + NAD(P)+
-
-
-
-
r
6-phospho-2-dehydro-D-gluconate + NAD(P)H
6-phospho-D-gluconate + NAD(P)+
-
-
-
-
r
6-phospho-2-dehydro-D-gluconate + NAD(P)H
6-phospho-D-gluconate + NAD(P)+
-
-
-
r
6-phospho-2-dehydro-D-gluconate + NAD(P)H
6-phospho-D-gluconate + NAD(P)+
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
Ankistrodesmus braunii
-
enzyme belongs to the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
Ankistrodesmus braunii C.C.A.P 202/7C
-
enzyme belongs to the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
enzyme involved in hexose monophosphate pathway, correlated to the rate of fatty acid synthesis
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
enzyme belongs to the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
?
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
?
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
enzyme belongs to the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
Zea mays x Tripsacum dactyloides
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-
-
-
?
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
enzyme belongs to the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
6-phospho-2-dehydro-D-gluconate + NADPH + H+
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-
-
-
?
6-phospho-D-gluconate + NADP+
6-phospho-2-dehydro-D-gluconate + NADPH + H+
-
-
-
-
?
D-glucose-6-phosphate + NAD+
2-dehydro-6-phospho-D-glucose + NADH
-
enzyme active with NAD+, 2% of the activity compared to 6-phosphogluconate when NAD+ is cofactor, no activity detected with NADP+ as cofactor
-
-
?
D-glucose-6-phosphate + NAD+
2-dehydro-6-phospho-D-glucose + NADH
-
-
-
-
?
D-glucose-6-phosphate + NAD+
2-dehydro-6-phospho-D-glucose + NADH
-
-
-
-
?
additional information
?
-
-
glucose, 2-deoxyglucose, gluconate, fructose-6-phosphate, glucose-1-phosphate, fructose-1,6-diphosphate, ribulose-5-phosphate and 1,3-diphosphoglycerate are no substrates
-
-
?
additional information
?
-
-
appears to lack 6PGAD except during growth on glucose or gluconate
-
-
?
additional information
?
-
-
fructose-6-phosphate and 2-keto-3-deoxy-6-phosphogluconate are not reduced
-
-
?
additional information
?
-
-
fructose-6-phosphate and 2-keto-3-deoxy-6-phosphogluconate are not reduced
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-phosphono-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
second step of hexose monophosphate shunt, i.e. HMS
-
-
?
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
Ankistrodesmus braunii
-
enzyme belongs to the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
Ankistrodesmus braunii C.C.A.P 202/7C
-
enzyme belongs to the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
enzyme involved in hexose monophosphate pathway, correlated to the rate of fatty acid synthesis
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
enzyme belongs to the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
enzyme belongs to the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
-
-
-
r
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
enzyme belongs to the oxidative pentose phosphate pathway
-
-
r
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Cd2+
-
the activity of 6PGD is stimulated after three days in the liver at a dose of 1 mg/l Cd and on the first day in gill, liver and kidney tissues at doses of 3 and 5 mg/l Cd. The stimulation effect of the 5 mg/l dose of Cd on G6PD and 6PGD enzyme activities is significantly diminished
Mg2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
30 kDa glycoprotein GF-AS
-
significant decrease in enzyme activity in chronic alcohol-treated rats
-
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
-
non-competitive inhibition
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
adenosine 5'-triphosphate
-
ATP inhibits the enzyme which is active with NAD+, not the NADP+ dependent activity
additional information
-
not inhibited by 5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, 5-(3alpha,12alpha-dihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, 5-(3alpha,acetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, 5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, and acetazolamide
-
ATP
-
with NAD+ as coenzyme, with NADP+ as coenzyme activity is less affected
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
nicotine activates the muscle, lungs, and testicular 6PGD enzyme activity but has no effect on heart and liver 6PGD activity, when nicotine is administered with vitamin E the increase in 6PGD enzyme activity in muscle and testicles are lower, vitamin E may favourably increase 6PGD enzyme activity in liver in nicotine treated rats, while it has negligible effects on this enzyme activity in other tissues
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.02
6-phospho-D-gluconate
-
isoform specific for NADP+ and isoform active with NAD+, with NADP+ as cofactor
0.04
6-phospho-D-gluconate
-
isoform specific for NADP+, with NADP+ as cofactor, glucose grown bacteria
0.04
6-phospho-D-gluconate
-
isoform specific for NADP+, with NADP+ as cofactor, 5 mM ATP, glucose grown bacteria
0.2
6-phospho-D-gluconate
-
isoform active with NAD+, NADP+ as cofactor, glucose grown bacteria
0.7
6-phospho-D-gluconate
-
isoform active with NAD as cofactor and isoform specific for NADP as cofactor, glucose grown bacteria
2
6-phospho-D-gluconate
-
isoform active with NAD+ as cofactor, 5 mM ATP, glucose grown bacteria
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.006
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
-
25°C, pH 8.0, non-competitive inhibition
0.0042
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
0.0878
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
3.66
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
Homo sapiens
-
25°C, pH 8.0, non-competitive inhibition
0.00253
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.0601
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-