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Information on EC 1.1.1.397 - beta-methylindole-3-pyruvate reductase for references in articles please use BRENDA:EC1.1.1.397
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IUBMB Comments The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan---tRNA ligase (EC 6.1.1.2).
The expected taxonomic range for this enzyme is: Streptomyces griseus subsp. griseus
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ind2
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gene name
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(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+ = (R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+
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(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate:NAD+ oxidoreductase
The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan---tRNA ligase (EC 6.1.1.2).
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(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+
(R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+
(R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+
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(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+
(R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+
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(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+
(R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+
(R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+
A0A0D4BSN8
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(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+
(R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+
A0A0D4BSN8
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UniProt
brenda
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UniProt
brenda
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IND2_STRGR
570
0
62085
Swiss-Prot
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expressed in Escherichia coli BW25113 cells
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Du, Y.; Alkhalaf, L.; Ryan, K.
In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly
Proc. Natl. Acad. Sci. USA
112
2717-2722
2015
Streptomyces griseus subsp. griseus (A0A0D4BSN8), Streptomyces griseus subsp. griseus ATCC 12648 (A0A0D4BSN8)
brenda
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1.1.1.397 beta-methylindole-3-pyruvate reductase
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