Reference on EC 1.1.1.34 - hydroxymethylglutaryl-CoA reductase (NADPH)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bucher, N.L.R.; Overath, P.; Lynen, F.
beta-Hydroxy-beta-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver
Biochim. Biophys. Acta
40
491-501
1960
Rattus norvegicus
Durr, I.F.; Rudney, H.
The reduction of beta-hydroxy-beta-methylglutaryl coenzyme A to mevalonic acid
J. Biol. Chem.
235
2572-2578
1960
Saccharomyces cerevisiae
Kawachi, T.; Rudney, H.
Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver
Biochemistry
9
1700-1705
1970
Rattus norvegicus
Madhosingh, C.; Migicovski, B.B.; Wood, I.M.
Inhibition of yeast hydroxymethylglutaryl-CoA reductase by a rat liver mitochondrial preperation
FEBS Lett.
46
20-22
1974
Saccharomyces cerevisiae, Rattus norvegicus
Heller, R.A.; Gould, R.G.
Prevention of cold inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by NADPH
Biochim. Biophys. Acta
388
254-259
1975
Rattus norvegicus
Madhosingh, C.; Orr, W.
Hydroxymethylglutaryl coenzyme A reductase in Fusarium oxysporum
Agric. Biol. Chem.
41
1519-1521
1977
Fusarium oxysporum
-
Madhosingh, C.; Orr, W.
Hydroxymethylglutaryl coenzyme A reductase purification and properties of the enzyme from Fusarium oxysporum
Biochim. Biophys. Acta
523
283-296
1978
Fusarium oxysporum
Preiss, B.; Lehoux, J.G.
Hydroxymethylglutaryl coenzyme A reductase activity in hamster adrenal mitochondria purified on a sucrose gradient
Biochem. Biophys. Res. Commun.
88
1140-1146
1979
Cricetinae
Ingebritsen, T.S.; Parker, R.A.; Gibson, D.M.
Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system
J. Biol. Chem.
256
1138-1144
1981
Rattus norvegicus
Gilbert, H.F.; Stewart, M.D.
Inactivation of hydroxymethylglutaryl-CoA reductase from yeast by coenzyme A disulfide
J. Biol. Chem.
256
1782-1785
1981
Saccharomyces cerevisiae
Young, N.L.; Saudek, C.D.; Crawford, S.A.; Zuckerbrod, S.L.
Recovery and activation from hydroxymethylglutaryl coenzyme A reductase from rat small intestine
J. Lipid Res.
23
257-265
1982
Rattus norvegicus
Sipat, A.P.
Hydroxymethylglutaryl CoA reductase (NADPH) in the latex of Hevea brasiliensis
Phytochemistry
21
2613-2618
1982
Hevea brasiliensis, Pisum sativum, Rattus norvegicus
-
Van Heusden, G.P.H.; Wirtz, K.W.A.
Hydroxymethylglutaryl CoA reductase and the modulation of microsomal cholesterol content by the none specific lipid transfer protein
J. Lipid Res.
25
27-32
1984
Rattus norvegicus
Arebalo, R.E.; Mitchell, Jr., E.D.
Cellular distribution of 3-hydroxy-3-methylglutaryl coenzyme A reductase and mevalonate kinase in leaves of Nepeta cataria
Phytochemistry
23
13-18
1984
Nepeta cataria
-
Harwood, Jr., H.J.; Schneider, M.; Stacpool, P.W.
Regulation of human leukocyte microsomal hydroxymethylglutaryl-CoA reductase activity by a phosphorylation and dephosphorylation mechanism
Biochim. Biophys. Acta
805
245-251
1984
Homo sapiens
Ness, G.C.; Eales, S.J.; Pendleton, L.C.; Smith, M.
Activation of rat liver microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase by NADPH
J. Biol. Chem.
260
12391-12393
1985
Rattus norvegicus
Feingold, K.R.; Moser, A.H.
The effect of substrates and competitive inhibitors on the phosphatase dependent activation of hepatic hydroxymethylglutaryl CoA reductase
Arch. Biochem. Biophys.
249
46-51
1986
Rattus norvegicus
Gibson, D.M.; Parker, R.A.
Hydroxymethylglutaryl-coenzyme A reductase
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
18
179-215
1987
Rattus norvegicus
-
Chen, G.Z.; Foster, L.; Bennet, J.L.
Purification and characterization of 3-hydroxymethylglutaryl-coenzyme A reductase of Schistosoma mansoni: Regulation of parasite enzyme activity differs from mammalien host
Exp. Parasitol.
73
82-92
1991
Schistosoma mansoni
Hupperich, M.; Thomer, A.; Kratz, K.; Eggerer, H.
Substrate and inhibitor specificity of 3-hydroxy-3-methylglutaryl-CoA reductase determined with substrate-analogue CoA-thioesters and CoA-thioethers
Biol. Chem. Hoppe-Seyler
372
857-863
1991
Homo sapiens
Ball, K.L.; Dale, S.; Weekes, J.; Hardie, D.G.
Biochemical characterization of two forms of 3-hydroxy-3-methylglutaryl-CoA reductase kinase from cauliflower (Brassica oleracea)
Eur. J. Biochem.
219
743-750
1994
Brassica oleracea
Bischoff, K.M.; Rodwell, V.W.
3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: Purification, characterization and expression in Escherichia coli
J. Bacteriol.
178
19-23
1996
Haloferax volcanii
Friesen, J.A.; Rodwell, V.W.
Identification of elements critical for phosphorylation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by adenosine monophosphate-activated protein kinase: Protein engineering of the naturally nonephosphorylatable 3-hydroxy-3-methylglutaryl coenzyme A reductase from Pseudomonas mevalonii
Biochemistry
36
1157-1162
1997
Pseudomonas mevalonii
Concepcion, J.L.; Gonzalez-Pakanowska, D.; Urbina, J.A.
3-Hydroxy-3-methylglutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: Subcellular localization and kinetic properties
Arch. Biochem. Biophys.
352
114-120
1998
Trypanosoma cruzi
Takahashi, S.; Kuzuyama, T.; Seto, H.
Purification, characterization, and cloning of a eubacterial 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme involved in biosynthesis of terpenoids
J. Bacteriol.
181
1256-1263
1999
Streptomyces sp.
Polo, M.; de Bravo, M.G.; Carbone, C.
3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in liver of athymic mice with or without an implanted human carcinoma
Comp. Biochem. Physiol. B
122
433-437
1999
Mus musculus
Montalvetti, A.; Pena-Diaz, J.; Hurtado, R.; Ruiz-Perez, L.M.; Gonzales-Pacanowska, D.
Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase
Biochem. J.
349
27-34
2000
Leishmania major
Bochar, D.A.; Brown, J.R.; Doolittle, W.F.; Klenk, H.P.; Lam, W.; Schenk, M.E.; Stauffacher, C.V.; Rodwell, V.W.
3-Hydroxy-3-methylglutaryl coenzyme A reductase of Sulfolobus solfataricus: DNA sequence, phylogeny, expression in Escherichia coli of the hmgA gene, and purification and kinetic properties of the gene product
J. Bacteriol.
179
3632-3638
1997
Saccharolobus solfataricus (Q980N1), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q980N1), Saccharolobus solfataricus P2
Kim, D.Y.; Bochar, D.A.; Stauffacher, C.V.; Rodwell, V.W.
Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus
Protein Expr. Purif.
17
435-442
1999
Saccharolobus solfataricus
Kim, D.Y.; Bochar, D.A.; Stauffacher, C.V.; Rodwell, V.W.
Engineering of Sulfolobus solfataricus HMG-CoA reductase to a form whose activity is regulated by phosphorylation and dephosphorylation
Biochemistry
39
2269-2275
2000
Saccharolobus solfataricus
Wilding, E.I.; Kim, D.Y.; Bryant, A.P.; Gwynn, N.M.; Lunsford, R.D.; McDavitt, D.; Myers, Jr., J.E.; Rosenberg, M.; Sylvester, D.; Stauffacher, C.V.; Rodwell, V.W.
Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus
J. Bacteriol.
182
5147-5152
2000
Staphylococcus aureus
Hedl, M.; Sutherlin, A.; Wilding, E.I.; Mazzulla, M.; McDevitt, D.; Lane, P.; Burgner, J.W.; Lehnbeuter, K.R.; Stauffacher, C.V.; Gwynn, M.N.; Rodwell, V.W.
Enterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis
J. Bacteriol.
184
2116-2122
2002
Enterococcus faecalis
Mokashi, V.; Singh, D.K.; Porter, T.D.
Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro
Arch. Biochem. Biophys.
433
474-480
2005
Rattus norvegicus
Li, S.; Friesen, J.A.; Fei, H.; Ding, X.; Borst, D.W.
The lobster mandibular organ produces soluble and membrane-bound forms of 3-hydroxy-3-methylglutaryl-CoA reductase
Biochem. J.
381
831-840
2004
Homarus americanus (Q7YT62), Homarus americanus (Q7YT63), Homarus americanus
Holdgate, G.A.; Ward, W.H.; McTaggart, F.
Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin
Biochem. Soc. Trans.
31
528-531
2003
Homo sapiens
Kondo, K.; Uritani, I.; Oba, K.
Induction mechanism of 3-hydroxy-3-methylglutaryl-CoA reductase in potato tuber and sweet potato root tissues
Biosci. Biotechnol. Biochem.
67
1007-1017
2003
Ipomoea batatas, Solanum tuberosum, Solanum x edinense
Sung, J.H.; Choi, S.J.; Lee, S.W.; Park, K.H.; Moon, T.W.
Isoflavones found in korean soybean paste as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
Biosci. Biotechnol. Biochem.
68
1051-1058
2004
Mesocricetus auratus
Garcia-Pelayo, M.C.; Garcia-Peregrin, E.; Martinez-Cayuela, M.
Differential translational effects of myristic acid and eicosapentaenoic acid on 3-hydroxy-3-methylglutaryl-CoA reductase from Reuber H35 hepatoma cells
Exp. Biol. Med.
229
781-786
2004
Homo sapiens
Hurtado-Guerrrero, R.; Pena-Diaz, J.; Montalvetti, A.; Ruiz-Perez, L.M.; Gonzalez-Pacanowska, D.
Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase
FEBS Lett.
510
141-144
2002
Trypanosoma cruzi
Tabernero, L.; Rodwell, V.W.; Stauffacher, C.V.
Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase
J. Biol. Chem.
278
19933-19938
2003
Pseudomonas mevalonii
Shearer, A.G.; Hampton, R.Y.
Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase
J. Biol. Chem.
279
188-196
2004
Saccharomyces cerevisiae
Holmberg, N.; Harker, M.; Wallace, A.D.; Clayton, J.C.; Gibbard, C.L.; Safford, R.
Co-expression of N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase and C24-sterol methyltransferase type 1 in transgenic tobacco enhances carbon flux towards end-product sterols
Plant J.
36
12-20
2003
Hevea brasiliensis
Suzuki, M.; Kamide, Y.; Nagata, N.; Seki, H.; Ohyama, K.; Kato, H.; Masuda, K.; Sato, S.; Kato, T.; Tabata, S.; Yoshida, S.; Muranaka, T.
Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels
Plant J.
37
750-761
2004
Arabidopsis thaliana
Shin, Y.; Vaziri, N.D.; Willekes, N.; Kim, C.H.; Joles, J.A.
Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and LDL receptor in hereditary analbuminemia
Am. J. Physiol. Endocrinol. Metab.
289
E993-E998
2005
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Lee, T.M.; Lin, M.S.; Chou, T.F.; Chang, N.C.
Additive effects of combined blockade of AT1 receptor and HMG-CoA reductase on left ventricular remodeling in infarcted rats
Am. J. Physiol. Heart Circ. Physiol.
291
H1281-H1289
2006
Rattus norvegicus
Muzio, G.; Martinasso, G.; Trombetta, A.; Di Simone, D.; Canuto, R.A.; Maggiora, M.
HMG-CoA reductase and PPARalpha are involved in clofibrate-induced apoptosis in human keratinocytes
Apoptosis
11
265-275
2006
Homo sapiens
Carbonell, T.; Freire, E.
Binding thermodynamics of statins to HMG-CoA reductase
Biochemistry
44
11741-11748
2005
Homo sapiens (P04035)
Jiang, J.; Kai, G.; Cao, X.; Chen, F.; He, D.; Liu, Q.
Molecular cloning of a HMG-CoA reductase gene from Eucommia ulmoides Oliver
Biosci. Rep.
26
171-181
2006
Eucommia ulmoides (Q5RZ62), Eucommia ulmoides
Duncan, R.E.; El-Sohemy, A.; Archer, M.C.
Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin
Cancer Lett.
224
221-228
2005
Homo sapiens
Ness, G.C.; Holland, R.C.; Lopez, D.
Selective compensatory induction of hepatic HMG-CoA reductase in response to inhibition of cholesterol absorption
Exp. Biol. Med.
231
559-565
2006
Rattus norvegicus (P51639)
Bidle, K.A.; Hanson, T.E.; Howell, K.; Nannen, J.
HMG-CoA reductase is regulated by salinity at the level of transcription in Haloferax volcanii
Extremophiles
11
49-55
2006
Haloferax volcanii
Datta, S.; Wang, L.; Moore, D.D.; Osborne, T.F.
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake
J. Biol. Chem.
281
807-812
2006
Mus musculus
Pallottini, V.; Martini, C.; Cavallini, G.; Donati, A.; Bergamini, E.; Notarnicola, M.; Caruso, M.G.; Trentalance, A.
Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia
J. Cell. Biochem.
98
1044-1053
2006
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Pallottini, V.; Martini, C.; Bassi, A.M.; Romano, P.; Nanni, G.; Trentalance, A.
Rat HMGCoA reductase activation in thioacetamide-induced liver injury is related to an increased reactive oxygen species content
J. Hepatol.
44
368-374
2006
Rattus norvegicus
Lee, P.C.; Nguyen, A.D.; Debose-Boyd, R.A.
Mutations within membrane domain of HMG CoA reductase confer resistance to sterol-accelerated degradation
J. Lipid Res.
48
318-327
2006
Cricetulus griseus (P00347), Cricetulus griseus
Lecian, D.; Demova, H.; Lodererova, A.; Zdychova, J.; Kluckova, H.; Teplan, V.; Voska, L.; Komers, R.
Renal effects of HMG-CoA reductase inhibition in a rat model of chronic inhibition of nitric oxide synthesis
Kidney Blood Press. Res.
29
135-143
2006
Rattus norvegicus
Leivar, P.; Gonzalez, V.M.; Castel, S.; Trelease, R.N.; Lopez-Iglesias, C.; Arro, M.; Boronat, A.; Campos, N.; Ferrer, A.; Fernandez-Busquets, X.
Subcellular localization of Arabidopsis 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Plant Physiol.
137
57-69
2005
Arabidopsis thaliana
Gueguen, Y.; Ferrari, L.; Souidi, M.; Batt, A.M.; Lutton, C.; Siest, G.; Visvikis, S.
Compared effect of immunosuppressive drugs cyclosporine A and rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG-CoA reductase
Basic Clin. Pharmacol. Toxicol.
100
392-397
2007
Homo sapiens
Bratton, L.D.; Auerbach, B.; Choi, C.; Dillon, L.; Hanselman, J.C.; Larsen, S.D.; Lu, G.; Olsen, K.; Pfefferkorn, J.A.; Robertson, A.; Sekerke, C.; Trivedi, B.K.; Unangst, P.C.
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase
Bioorg. Med. Chem.
15
5576-5589
2007
Rattus norvegicus
Pak, V.V.; Koo, M.; Kim, M.J.; Yun, L.; Kwon, D.Y.
Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone
Bioorg. Med. Chem.
16
1309-1318
2008
Rattus norvegicus
Pfefferkorn, J.A.; Choi, C.; Song, Y.; Trivedi, B.K.; Larsen, S.D.; Askew, V.; Dillon, L.; Hanselman, J.C.; Lin, Z.; Lu, G.; Robertson, A.; Sekerke, C.; Auerbach, B.; Pavlovsky, A.; Harris, M.S.; Bainbridge, G.; Caspers, N.
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors
Bioorg. Med. Chem. Lett.
17
4531-4537
2007
Mus musculus
Shang, C.H.; Zhu, F.; Li, N.; Ou-Yang, X.; Shi, L.; Zhao, M.W.; Li, Y.X.
Cloning and characterization of a gene encoding HMG-CoA reductase from Ganoderma lucidum and its functional identification in yeast
Biosci. Biotechnol. Biochem.
72
1333-1339
2008
Ganoderma lucidum (B2KX91), Ganoderma lucidum
Vaupotic, T.; Plemenitas, A.
Osmoadaptation-dependent activity of microsomal HMG-CoA reductase in the extremely halotolerant black yeast Hortaea werneckii is regulated by ubiquitination
FEBS Lett.
581
3391-3395
2007
Hortaea werneckii
Burse, A.; Frick, S.; Schmidt, A.; Buechler, R.; Kunert, M.; Gershenzon, J.; Brandt, W.; Boland, W.
Implication of HMGR in homeostasis of sequestered and de novo produced precursors of the iridoid biosynthesis in leaf beetle larvae
Insect Biochem. Mol. Biol.
38
76-88
2008
Phaedon cochleariae
Schiefelbein, D.; Goren, I.; Fisslthaler, B.; Schmidt, H.; Geisslinger, G.; Pfeilschifter, J.; Frank, S.
Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses
J. Biol. Chem.
283
15479-15490
2008
Mus musculus, Mus musculus C57/BL6J
Pak, V.V.; Koo, M.; Kim, M.J.; Yang, H.J.; Yun, L.; Kwon, D.Y.
Modeling an active conformation for linear peptides and design of a competitive inhibitor for HMG-CoA reductase
J. Mol. Recognit.
21
224-232
2008
Rattus norvegicus
Munoz-Bertomeu, J.; Sales, E.; Ros, R.; Arrillaga, I.; Segura, J.
Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia
Plant Biotechnol. J.
5
746-758
2007
Arabidopsis thaliana
Ohto, C.; Muramatsu, M.; Obata, S.; Sakuradani, E.; Shimizu, S.
Overexpression of the gene encoding HMG-CoA reductase in Saccharomyces cerevisiae for production of prenyl alcohols
Appl. Microbiol. Biotechnol.
82
837-845
2009
Saccharomyces cerevisiae (P12683), Saccharomyces cerevisiae
Subbaiah, P.V.; Sowa, J.M.; Singh, D.K.
Sphingolipids and cellular cholesterol homeostasis. Effect of ceramide on cholesterol trafficking and HMG CoA reductase activity
Arch. Biochem. Biophys.
474
32-38
2008
Homo sapiens
Hosoda, S.; Matsuda, D.; Tomoda, H.; Hashimoto, M.; Aoyama, H.; Hashimoto, Y.
Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors
Bioorg. Med. Chem. Lett.
19
4228-4231
2009
Rattus norvegicus
Seiki, S.; Frishman, W.H.
Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia
Cardiol. Rev.
17
70-76
2009
Homo sapiens
Wysocka-Kapcinska, M.; Lutyk-Nadolska, J.; Kiliszek, M.; Plochocka, D.; Maciag, M.; Leszczynska, A.; Rytka, J.; Burzynska, B.
Functional expression of human HMG-CoA reductase in Saccharomyces cerevisiae: a system to analyse normal and mutated versions of the enzyme in the context of statin treatment
J. Appl. Microbiol.
106
895-902
2009
Homo sapiens
Cao, X.; Zong, Z.; Ju, X.; Sun, Y.; Dai, C.; Liu, Q.; Jiang, J.
Molecular cloning, characterization and function analysis of the gene encoding HMG-CoA reductase from Euphorbia pekinensis Rupr.
Mol. Biol. Rep.
37
1559-1566
2009
Euphorbia pekinensis (A0N0D3), Euphorbia pekinensis
Nieto, B.; Fores, O.; Arro, M.; Ferrer, A.
Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways
Phytochemistry
70
53-59
2009
Arabidopsis thaliana
Aquil, S.; Husaini, A.M.; Abdin, M.Z.; Rather, G.M.
Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants
Planta Med.
75
1453-1458
2009
Catharanthus roseus
Vaupotic, T.; Veranic, P.; Petrovic, U.; Gunde-Cimerman, N.; Plemenitas, A.
HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi
Stud. Mycol.
61
61-66
2008
Aspergillus amstelodami, Aureobasidium pullulans, Saccharomyces cerevisiae, Debaryomyces hansenii, Hortaea werneckii, Neophaeotheca triangularis, Trimmatostroma salinum, Wallemia ichthyophaga, Saccharomyces cerevisiae MZKI K86, Wallemia ichthyophaga EXF 994, Neophaeotheca triangularis MZKI B741, Aureobasidium pullulans MZKI B802, Hortaea werneckii MZKI B736, Aspergillus amstelodami MZKI A561, Debaryomyces hansenii CBS 767, Trimmatostroma salinum MZKI B734
Lin, J.; Jin, Y.; Zhou, M.; Zhou, X.; Wang, J.
Molecular cloning, characterization and functional analysis of a 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Jatropha curcas
Afr. J. Biotechnol.
8
3455-3462
2009
Jatropha curcas
-
Perchellet, J.P.; Perchellet, E.M.; Crow, K.R.; Buszek, K.R.; Brown, N.; Ellappan, S.; Gao, G.; Luo, D.; Minatoya, M.; Lushington, G.H.
Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins
Int. J. Mol. Med.
24
633-643
2009
Homo sapiens (P04035), Homo sapiens
Gholamhoseinian, A.; Shahouzehi, B.; Sharifi-Far, F.
Inhibitory activity of some plant methanol extracts on 3-hydroxy-3-methylglutaryl coenzyme A reductase
Int. J. Pharmacol.
6
705-711
2010
Homo sapiens
-
Leopoldini, M.; Malaj, N.; Toscano, M.; Sindona, G.; Russo, N.
On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme
J. Agric. Food Chem.
58
10768-10773
2010
Homo sapiens (P04035)
Mozzicafreddo, M.; Cuccioloni, M.; Eleuteri, A.; Angeletti, M.
Rapid reverse phase-HPLC assay of HMG-CoA reductase activity
J. Lipid Res.
51
2460-2463
2010
Homo sapiens
Pak, V.V.; Koo, M.; Kwon, D.Y.; Yun, L.
Design of a highly potent inhibitory peptide acting as a competitive inhibitor of HMG-CoA reductase
Amino Acids
43
2015-2025
2012
Homo sapiens
Sashidhara, K.V.; Singh, S.P.; Srivastava, A.; Puri, A.; Chhonker, Y.S.; Bhatta, R.S.; Shah, P.; Siddiqi, M.I.
Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent
Eur. J. Med. Chem.
46
5206-5211
2011
Mesocricetus auratus
Chen, X.; Wang, X.; Li, Z.; Kong, L.; Liu, G.; Fu, J.; Wang, A.
Molecular cloning, tissue expression and protein structure prediction of the porcine 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) gene
Gene
495
170-177
2012
Sus scrofa (Q1W675), Sus scrofa
Rui, X.; Caiqin, L.; Wangjin, L.; Juan, D.; Zehuai, W.; Jianguo, L.
3-Hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) is highly associated with the cell division during the early stage of fruit development which determines the final fruit size in Litchi chinensis
Gene
498
28-35
2012
Litchi chinensis
Song, A.A.; Abdullah, J.O.; Abdullah, M.P.; Shafee, N.; Othman, R.; Tan, E.F.; Noor, N.M.; Raha, A.R.
Overexpressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) in the lactococcal mevalonate pathway for heterologous plant sesquiterpene production
PLoS ONE
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Lactococcus lactis, Lactococcus lactis NZ9000
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3-Hydroxy-3-methylglutaryl-coenzyme A reductase of Haloferax volcanii: role of histidine 398 and attenuation of activity by introduction of negative charge at position 404
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Haloferax volcanii (Q59468), Haloferax volcanii, Haloferax volcanii DSM 3757 (Q59468)
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Homo sapiens (P04035)
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Determination of 3-hydroxy-3-methylglutaryl CoA reductase activity in plants
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Arabidopsis thaliana, Arachis hypogaea, Artemisia annua, Bixa orellana, Brassica napus, Cannabis sativa, Cucumis melo, Daucus carota, Dunaliella salina, Euphorbia lathyris, Glycine max, Gossypium barbadense, Gossypium hirsutum, Helianthus tuberosus, Hevea brasiliensis, Hordeum vulgare, Ipomoea batatas, Lithospermum erythrorhizon, Malus domestica, Medicago sativa, Nepeta cataria, Nicotiana benthamiana, Nicotiana tabacum, Ochromonas malhamensis, Parthenium argentatum, Persea americana, Picea abies, Pimpinella anisum, Pisum sativum, Raphanus sativus, Salvia miltiorrhiza, Sinapis alba, Solanum lycopersicum, Solanum tuberosum, Solanum virginianum, Spinacia oleracea, Stevia rebaudiana, Taraxacum brevicorniculatum, Vigna radiata var. radiata, Zea mays
Dinesh, N.; Pallerla, D.S.R.; Kaur, P.K.; Babu, N.K.; Singh, S.
Exploring Leishmania donovani 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) as a potential drug target by biochemical, biophysical and inhibition studies
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Leishmania donovani (I7CKJ5), Leishmania donovani, Leishmania donovani MHOM/80/IN/Dd8 (I7CKJ5)
Kalita, R.; Patar, L.; Shasany, A.K.; Modi, M.K.; Sen, P.
Molecular cloning, characterization and expression analysis of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Centella asiatica L.
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Centella asiatica (W6APW1), Centella asiatica
Gu, W.; Geng, C.; Xue, W.; Wu, Q.; Chao, J.; Xu, F.; Sun, H.; Jiang, L.; Han, Y.; Zhang, S.
Characterization and function of the 3-hydroxy-3-methylglutaryl-CoA reductase gene in Alisma orientale (Sam.) Juz. and its relationship with protostane triterpene production
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Alisma plantago-aquatica subsp. orientale (F1DTB9), Alisma plantago-aquatica subsp. orientale
Kildegaard, K.R.; Adiego-Perez, B.; Domenech Belda, D.; Khangura, J.K.; Holkenbrink, C.; Borodina, I.
Engineering of Yarrowia lipolytica for production of astaxanthin
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Yarrowia lipolytica (Q6C704)
Wu, C.; Lan, L.; Li, Y.; Nie, Z.; Zeng, R.
The relationship between latex metabolism gene expression with rubber yield and related traits in Hevea brasiliensis
BMC Genomics
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Hevea brasiliensis (Q547W6), Hevea brasiliensis
Liu, J.P.; Hu, J.; Liu, Y.H.; Yang, C.P.; Zhuang, Y.F.; Guo, X.L.; Li, Y.J.; Zhang, L.
Transcriptome analysis of Hevea brasiliensis in response to exogenous methyl jasmonate provides novel insights into regulation of jasmonate-elicited rubber biosynthesis
Physiol. Mol. Biol. Plants
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Hevea brasiliensis
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An insight into structure, function, and expression analysis of 3-hydroxy-3-methylglutaryl-CoA reductase of Cymbopogon winterianus
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Cymbopogon winterianus (A0A0A7HSZ2), Cymbopogon winterianus
Zhao, Q.; Li, R.; Chen, X.; Yang, Q.; Li, J.
Cloning and characterization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase from Fritillaria cirrhosa D. Don
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Fritillaria cirrhosa
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Wei, H.; Xu, C.; Movahedi, A.; Sun, W.; Li, D.; Zhuge, Q.
Characterization and function of 3-hydroxy-3-methylglutaryl-CoA reductase in Populus trichocarpa overexpression of PtHMGR enhances terpenoids in transgenic poplar
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Populus trichocarpa (B9GJZ3), Populus trichocarpa
Zheng, T.; Dong, T.; Haider, M.S.; Jin, H.; Jia, H.; Fang, J.
Brassinosteroid regulates 3-hydroxy-3-methylglutaryl CoA reductase to promote grape fruit development
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Vitis vinifera
Costa, C.H.S.; Oliveira, A.R.S.; Dos Santos, A.M.; da Costa, K.S.; Lima, A.H.L.E.; Alves, C.N.; Lameira, J.
Computational study of conformational changes in human 3-hydroxy-3-methylglutaryl coenzyme reductase induced by substrate binding
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Homo sapiens (P04035), Homo sapiens
Andrade-Pavon, D.; Ortiz-Alvarez, J.; Sanchez-Sandoval, E.; Tamariz, J.; Hernandez-Rodriguez, C.; Ibarra, J.A.; Villa-Tanaca, L.
Inhibition of recombinant enzyme 3-hydroxy-3-methylglutaryl-CoA reductase from Candida glabrata by alpha-asarone-based synthetic compounds as antifungal agents
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[Candida] glabrata, [Candida] glabrata CBS138
Ando, H.; Horibata, Y.; Aoyama, C.; Shimizu, H.; Shinohara, Y.; Yamashita, S.; Sugimoto, H.
Side-chain oxysterols suppress the transcription of CTP phosphoethanolamine cytidylyltransferase and 3-hydroxy-3-methylglutaryl-CoA reductase by inhibiting the interaction of p300 and NF-Y, and H3K27 acetylation
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Homo sapiens (P04035), Mus musculus (Q01237)
Robertlee, J.; Kobayashi, K.; Tang, J.; Suzuki, M.; Muranaka, T.
Evidence that the Arabidopsis thaliana 3-hydroxy-3-methylglutaryl-CoA reductase 1 is phosphorylated at Ser577 in planta
Plant Biotechnol.
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Arabidopsis thaliana (P14891), Arabidopsis thaliana
Zhang, M.; Liu, H.; Wang, Q.; Liu, S.; Zhang, Y.
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase 5 gene from Malus domestica enhances oxidative stress tolerance in Arabidopsis thaliana
Plant Physiol. Biochem.
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Malus domestica
Zhang, G.; Wu, Y.; Haq Muhammad, Z.U.; Yang, Y.; Yu, J.; Zhang, J.; Yang, D.
cDNA cloning, prokaryotic expression and functional analysis of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) in Pogostemon cablin
Protein Expr. Purif.
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Pogostemon cablin (A0A5J6DKK9), Pogostemon cablin
Rao, S.; Meng, X.; Liao, Y.; Yu, T.; Cao, J.; Tan, J.; Xu, F.; Cheng, S.
Characterization and functional analysis of two novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase genes (GbHMGR2 and GbHMGR3) from Ginkgo biloba
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Ginkgo biloba (A0A385FV32), Ginkgo biloba (A0A3S8X7U0), Ginkgo biloba
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