Information on EC 1.1.1.339 - dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.1.1.339

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EC Tree 1 Oxidoreductases 1.1 Acting on the CH-OH group of donors 1.1.1 With NAD⁺ or NADP⁺ as acceptor 1.1.1.339 dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)

IUBMB Comments

The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP⁺.

The enzyme appears in viruses and cellular organisms

Reaction Schemes

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dTDP-6-deoxy-beta-L-talose

NAD+

dTDP-4-dehydro-beta-L-rhamnose

NADH

H+

Synonyms
dTDP-6-deoxy-L-lyxo-4-hexulose reductase, tll, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

dTDP-6-deoxy-L-lyxo-4-hexulose reductase

Aggregatibacter actinomycetemcomitans

285845

tll

2 entries

tll

Aggregatibacter actinomycetemcomitans

285845

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

dTDP-6-deoxy-beta-L-talose + NAD+ = dTDP-4-dehydro-beta-L-rhamnose + NADH + H+

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PATHWAY SOURCE

PATHWAYS

KEGG

Biosynthesis of secondary metabolites, O-Antigen nucleotide sugar biosynthesis, Polyketide sugar unit biosynthesis

MetaCyc

superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis

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SYSTEMATIC NAME

IUBMB Comments

dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase

The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+.

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

dTDP-4-dehydro-6-deoxy-beta-L-mannose + NADH + H+

dTDP-6-deoxy-beta-L-talose + NAD+

2 entries

dTDP-4-dehydro-6-deoxy-beta-L-mannose + NADH + H+

dTDP-6-deoxy-beta-L-talose + NAD+

Aggregatibacter actinomycetemcomitans

285845

Substrates: -
Products: -

dTDP-4-dehydro-6-deoxy-beta-L-mannose + NADH + H+

dTDP-6-deoxy-beta-L-talose + NAD+

Aggregatibacter actinomycetemcomitans NCTC 9710

285845

Substrates: -
Products: -

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Aggregatibacter actinomycetemcomitans

NCTC 9710

285845

brenda

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Highest Expressing Human Cell Lines

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

2 entries

physiological function

Aggregatibacter actinomycetemcomitans

enzyme is part of the pathway leading to the unusual sugar, 6-deoxy-L-talose, which is a conctituent of cell wall components in some bacteria

285845

physiological function

Aggregatibacter actinomycetemcomitans NCTC 9710

enzyme is part of the pathway leading to the unusual sugar, 6-deoxy-L-talose, which is a conctituent of cell wall components in some bacteria

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

O66256 pBLAST

TLL_AGGAC

Aggregatibacter actinomycetemcomitans

270

30680

Swiss-Prot