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EC Tree
IUBMB CommentsMay be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)].
The enzyme appears in viruses and cellular organisms
Synonyms
mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase,
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mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase
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(R)-mevalonate + NADP+ = mevaldate + NADPH + H+
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(R)-mevalonate:NADP+ oxidoreductase
May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)].
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(3RS)-mevaldate + NADPH + H+
(R)-mevalonate + NADP+
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r
(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADPH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NADP+
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ir
(S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
(S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
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ir
4-cyanobenzaldehyde + NADPH
4-cyanobenzylalcohol + NADP+
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ir
pyridine-3-carboxaldehyde + NADPH
pyridine-3-methanol + NADP+
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ir
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(R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADPH
(R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NADP+
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ir
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NADH
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giving one-fifth of the rate obtained with NADPH
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Sodium aminobarbitone
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1 mM, 48% inhibition, noncompetitive
Thiobarbituric acid
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1 mM, 22% inhibition, noncompetitive
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0.15
4-cyanobenzaldehyde
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brenda
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AK1A1_MOUSE
325
0
36587
Swiss-Prot
other Location (Reliability: 3)
AK1A1_PIG
325
0
36582
Swiss-Prot
other Location (Reliability: 3)
AK1A1_PONAB
325
0
36390
Swiss-Prot
other Location (Reliability: 3)
AK1A1_RAT
325
0
36506
Swiss-Prot
other Location (Reliability: 3)
AK1A1_BOVIN
325
0
36617
Swiss-Prot
other Location (Reliability: 3)
AK1A1_CRIGR
324
0
36510
Swiss-Prot
other Location (Reliability: 3)
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-20°C, 3 months, 0% loss of activity
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ammonium sulfate precipitation, calcium phosphate gel, gel filtration
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Beedle, A.S.; Rees, H.H.; Goodwin, T.W.
Some properties and a suggested reclassification of mevaldate reductase
Biochem. J.
139
205-209
1974
Sus scrofa
brenda
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1.1.1.33 mevaldate reductase (NADPH)
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