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Information on EC 1.1.1.307 - D-xylose reductase [NAD(P)H]

for references in articles please use BRENDA:EC1.1.1.307

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IUBMB Comments

Xylose reductases catalyse the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. Most of the enzymes exhibit a strict requirement for NADPH [cf. EC 1.1.1.431, D-xylose reductase (NADPH)]. However, a few D-xylose reductases, such as those from Neurospora crassa , Yamadazyma tenuis [2,3], Scheffersomyces stipitis , and the thermophilic fungus Chaetomium thermophilum [4,7], have dual coenzyme specificity, though they still prefer NADPH to NADH. Very rarely the enzyme prefers NADH [cf. EC 1.1.1.430, D-xylose reductase (NADH)].

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes

Synonyms
akr2b5, kmxyl1, nad(p)h-dependent xr, nad(p)h-dependent d-xylose reductase, nad(p)h-linked xylose reductase, nadp-dependent xylose reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS