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Information on EC - methylglyoxal reductase (NADPH)

for references in articles please use BRENDA:EC1.1.1.283
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IUBMB Comments
The enzyme from the yeast Saccharomyces cerevisiae catalyses the reduction of a keto group in a number of compounds, forming enantiopure products. Among the substrates are methylglyoxal (which is reduced to (S)-lactaldehyde) [1,2], 3-methylbutanal , hexane-2,5-dione and 3-chloro-1-phenylpropan-1-one . The enzyme differs from EC, methylglyoxal reductase (NADH), which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms, AKR, aldo-keto reductase, D-lactaldehyde dehydrogenase, Gre2, GRE2 gene product, GRE2/YOL151W, Gre2p, MeGR, methylglyoxal reductase, more
(S)-lactaldehyde + NADP+ = 2-oxopropanal + NADPH + H+
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