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Information on EC 1.1.1.252 - tetrahydroxynaphthalene reductase

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IUBMB Comments
Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. Involved with EC 4.2.1.94 scytalone dehydratase in the biosynthesis of melanin in pathogenic fungi.
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The enzyme appears in viruses and cellular organisms
Synonyms
1,3,6,8-tetrahydroxynaphthalene reductase, 1,3,8-trihydroxynaphthalene reductase, 3HNR, 4HN, EC 1.3.1.50, hydroxynaphthalene reductase, MGG_02252, NADPH-dependent naphthol reductase, naphthol reductase, reductase, naphthol, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
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