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Information on EC 1.1.1.219 - dihydroflavonol 4-reductase

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IUBMB Comments
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
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The enzyme appears in viruses and cellular organisms
Synonyms
flavonoid 3'-hydroxylase, dihydroflavonol reductase, dihydroflavonol-4-reductase, csdfr, tadfr, ibdfr, mcdfr, gbdfr1, gbdfr2, gbdfr3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+
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