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Information on EC 1.1.1.215 - gluconate 2-dehydrogenase
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1.1.1.215 gluconate 2-dehydrogenaseIUBMB Comments
Also acts on L-idonate, D-galactonate and D-xylonate.
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Word Map
- 1.1.1.215
-
2-keto-d-gluconic
- gluconobacter
- oxydans
- 5-keto-d-gluconate
- gluconokinase
- 6-phosphogluconate
-
entner-doudoroff
- l-idonate
- cypripedii
-
2.7.1.12
- synthesis
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
gluconate dehydrogenase, fad-gadh, ga2dh, gluconate-2-dehydrogenase, 2-ketoaldonate reductase, l-2-hydroxyacid dehydrogenase, 2-keto-l-gulonate reductase, 2-ketogluconate reductase, 2-ketogluconate dehydrogenase, gox0417, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
2-HDH
2-keto-D-gluconate reductase
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2-keto-D-gluconate-yielding D-gluconate dehydrogenase
2-keto-L-gulonate reductase
2-ketoaldonate reductase
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2-ketogluconate dehydrogenase
2-ketogluconate reductase
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2KGA reductase
2KGR
2KR
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-
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FAD-GADH
GA2DH
GAD
GADH
gluconate dehydrogenase
gluconate-2-dehydrogenase
GluD
Gox0417
GOX1230
HDH
L-2-hydroxyacid dehydrogenase
NADPH requiring 2-keto-L-gulonate reductase
reductase, 2-ketogluconate
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
D-gluconate:NADP+ oxidoreductase
Also acts on L-idonate, D-galactonate and D-xylonate.
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CAS REGISTRY NUMBER
COMMENTARY
68417-42-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
glyoxal + NADPH
?
-
reduction at 33% the rate of 2-ketogluconate reduction
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-
?
glyoxylate + NADPH
glycolate + NADP+
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reduction at 350% the rate of 2-ketogluconate reduction
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?
hydroxypyruvate + NADPH
2,3-dihydroxypropanoate + NADP+
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reduction at 733% the rate of 2-keto-gluconate reduction
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?
pyruvate + NADPH + H+
lactate + NADP+
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reduction at 7% the rate of 2-ketogluconate reduction
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?
2,5-diketo-D-gluconate + NADPH
5-keto-D-gluconate + NADP+
Brevibacterium ketosoreductum
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-
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ir
2,5-diketo-D-gluconate + NADPH
5-keto-D-gluconate + NADP+
Brevibacterium ketosoreductum ATCC 21914
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-
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ir
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
acetic acid bacteria
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2-keto-D-gluconate, part of non-phosphorylative pathway of carbohydrates predominantly in acetic acid bacteria
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?
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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i.e. 2-keto-D-gluconate, best substrate for Acetobacter ascendens and Gluconobacter
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r
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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i.e. 2-keto-D-gluconate, best substrate for Acetobacter ascendens and Gluconobacter
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r
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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strongly preferred reaction of Acetobacter enzyme
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r
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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equal reaction rate of reduction of 2-ketogluconate and oxidation of gluconate with Gluconobacter enzyme
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r
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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strongly preferred reaction of Acetobacter enzyme
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r
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
Brevibacterium ketosoreductum
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-
-
?
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
Brevibacterium ketosoreductum
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11.8% of activity with 2,5-diketo-D-gluconate
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?
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
Brevibacterium ketosoreductum ATCC 21914
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-
-
?
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
Brevibacterium ketosoreductum ATCC 21914
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11.8% of activity with 2,5-diketo-D-gluconate
-
?
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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i.e. 2-keto-D-gluconate, best substrate for Acetobacter ascendens and Gluconobacter
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r
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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reverse reaction at the same rate by Gluconobacter enzyme
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r
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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i.e. 2-keto-D-gluconate, best substrate for Acetobacter ascendens and Gluconobacter
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r
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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reverse reaction at the same rate by Gluconobacter enzyme
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r
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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-
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?
2-keto-L-gluconic acid + NADPH + H+
L-idonate + NADP+
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-
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?
2-keto-L-gulonate + NADPH
L-idonate + NADP+
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third best substrate
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r
2-keto-L-gulonate + NADPH
L-idonate + NADP+
Brevibacterium ketosoreductum
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10.8% of activity with 2,5-diketo-D-gluconate
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?
2-keto-L-gulonate + NADPH
L-idonate + NADP+
Brevibacterium ketosoreductum ATCC 21914
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10.8% of activity with 2,5-diketo-D-gluconate
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?
2-keto-L-gulonate + NADPH
L-idonate + NADP+
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third best substrate
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r
2-keto-L-gulonate + NADPH
L-idonate + NADP+
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third best substrate
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r
2-oxo-D-gluconate + NADH + H+
D-gluconate + NAD+
enzyme shows dual cofactor specificity, being able to use both NADPH and NADH
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?
2-oxo-D-gluconate + NADH + H+
D-gluconate + NAD+
enzyme shows dual cofactor specificity, being able to use both NADPH and NADH
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?
2-oxo-D-gluconate + NADPH + H+
D-gluconate + NADP+
enzyme shows dual cofactor specificity, being able to use both NADPH and NADH
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?
2-oxo-D-gluconate + NADPH + H+
D-gluconate + NADP+
enzyme shows dual cofactor specificity, being able to use both NADPH and NADH
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?
2-oxo-L-gulonate + NADPH + H+
L-idonate + NADP+
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r
2-oxo-L-gulonate + NADPH + H+
L-idonate + NADP+
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r
5-keto-D-gluconate + NADPH
D-gluconate + NADP+
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poor substrate
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?
5-keto-D-gluconate + NADPH
D-gluconate + NADP+
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poor substrate
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?
5-keto-D-gluconate + NADPH
D-gluconate + NADP+
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poor substrate
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?
5-keto-D-gluconate + NADPH
D-gluconate + NADP+
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poor substrate
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?
D-galactonate + NADP+
2-dehydro-D-galactonate + NADPH
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r
D-galactonate + NADP+
2-dehydro-D-galactonate + NADPH
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r
D-galactonate + NADP+
2-dehydro-D-galactonate + NADPH
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third best substrate
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r
D-galactonate + NADP+
2-dehydro-D-galactonate + NADPH
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third best substrate
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r
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH
the large subunit is the catalytically active enzyme part, high substrate and regiospecificity
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?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH
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?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH
the large subunit is the catalytically active enzyme part, high substrate and regiospecificity
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?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH + H+
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wild-type exhibits gluconate-dependent respiration. Genes cj0414 and cj0415, orthologous to GADH, are co-transcribed. Campylobacter jejuni 81176 does not use gluconate compounds as sole carbon sources. GADH plays a minor role in mouse colonization
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?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH + H+
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wild-type exhibits gluconate-dependent respiration. Genes cj0414 and cj0415, orthologous to GADH, are co-transcribed. Campylobacter jejuni 81176 does not use gluconate compounds as sole carbon sources. GADH plays a minor role in mouse colonization
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?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH + H+
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?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH + H+
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?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH + H+
the ability of CHA0 to acidify its environment is largely determined by its ability to produce gluconic acid from glucose
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?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH + H+
the ability of CHA0 to acidify its environment is largely determined by its ability to produce gluconic acid from glucose
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?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH + H+
Pseudomonas plecoglossicida JUIM01
A0A2H4PJM1; A0A2H4PJM2; A0A2H4PJM7
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-
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?
L-idonate + NADP+
2-keto-L-idonate + NADPH
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poor substrate
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?
L-idonate + NADP+
2-keto-L-idonate + NADPH
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best substrate
-
?
L-idonate + NADP+
2-oxo-L-gulonate + NADPH + H+
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-
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r
L-idonate + NADP+
2-oxo-L-gulonate + NADPH + H+
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-
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r
additional information
?
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-
no substrates are: 6-phospho-D-gluconate, D-mannonate, D-arabonate
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?
additional information
?
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D-xylonate, D-glucose, D-fructose, L-sorbose, 5-keto-D-fructose, D-sorbitol, glycerol
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?
additional information
?
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no substrates are: 6-phospho-D-gluconate, D-mannonate, D-arabonate
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?
additional information
?
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no substrates are: 6-phospho-D-gluconate, D-mannonate, D-arabonate
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?
additional information
?
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no substrates are: 6-phospho-D-gluconate, D-mannonate, D-arabonate
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?
additional information
?
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for large-scale production of 2-dehydro-D-gluconate, the cells require for formation of 2-dehydro-D-gluconate from D-gluconate oxygen as the final acceptor of electrons formed during the oxidation ofD -gluconate
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?
additional information
?
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for large-scale production of 2-dehydro-D-gluconate, the cells require for formation of 2-dehydro-D-gluconate from D-gluconate oxygen as the final acceptor of electrons formed during the oxidation ofD -gluconate
-
-
?
additional information
?
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for large-scale production of 2-dehydro-D-gluconate, the cells require for formation of 2-dehydro-D-gluconate from D-gluconate oxygen as the final acceptor of electrons formed during the oxidation ofD -gluconate
-
-
?
additional information
?
-
A0A2H4PJM1; A0A2H4PJM2; A0A2H4PJM7
no activity on other sugars and sugar acids
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-
-
additional information
?
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no activity on other sugars and sugar acids
-
-
-
additional information
?
-
Pseudomonas plecoglossicida JUIM01
A0A2H4PJM1; A0A2H4PJM2; A0A2H4PJM7
no activity on other sugars and sugar acids
-
-
-
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,5-diketo-D-gluconate + NADPH
5-keto-D-gluconate + NADP+
Brevibacterium ketosoreductum
-
-
-
ir
2,5-diketo-D-gluconate + NADPH
5-keto-D-gluconate + NADP+
Brevibacterium ketosoreductum ATCC 21914
-
-
-
ir
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
acetic acid bacteria
-
2-keto-D-gluconate, part of non-phosphorylative pathway of carbohydrates predominantly in acetic acid bacteria
-
?
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
Brevibacterium ketosoreductum
-
-
-
?
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
Brevibacterium ketosoreductum ATCC 21914
-
-
-
?
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
reverse reaction at the same rate by Gluconobacter enzyme
-
r
2-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
reverse reaction at the same rate by Gluconobacter enzyme
-
r
2-keto-L-gluconic acid + NADPH + H+
L-idonate + NADP+
-
-
-
-
?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH
-
-
-
?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH + H+
-
-
-
-
?
D-gluconate + NADP+
2-dehydro-D-gluconate + NADPH + H+
-
-
-
?
additional information
?
-
for large-scale production of 2-dehydro-D-gluconate, the cells require for formation of 2-dehydro-D-gluconate from D-gluconate oxygen as the final acceptor of electrons formed during the oxidation ofD -gluconate
-
-
?
additional information
?
-
-
for large-scale production of 2-dehydro-D-gluconate, the cells require for formation of 2-dehydro-D-gluconate from D-gluconate oxygen as the final acceptor of electrons formed during the oxidation ofD -gluconate
-
-
?
additional information
?
-
for large-scale production of 2-dehydro-D-gluconate, the cells require for formation of 2-dehydro-D-gluconate from D-gluconate oxygen as the final acceptor of electrons formed during the oxidation ofD -gluconate
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE