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Information on EC 1.1.1.20 - glucuronolactone reductase for references in articles please use BRENDA:EC1.1.1.20Word Map on EC 1.1.1.20
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The expected taxonomic range for this enzyme is: Rattus norvegicus
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glucuronolactone reductase
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L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + NADPH + H+
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Ascorbate and aldarate metabolism
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L-gulono-1,4-lactone:NADP+ 1-oxidoreductase
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gulonolactone dehydrogenase
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reductase, glucuronolactone
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brenda
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D-galacturonic acid + NADPH
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?
D-glucuronic acid + NADPH
L-gulonic acid + NADP+
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?
D-glucurono-3,6-lactone + NADPH
D-gulono-1,4-lactone + NADP+
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oxidation activity is very low
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r
D-iduronic acid + NADPH
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erythrose + NADPH
glycerol + NADP+
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glyceraldehyde + NADPH
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?
L-gulono-1,4-lactone + NADP+
D-glucurono-3,6-lactone + NADPH
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L-gulono-1,4-lactone + NADP+
D-glucurono-3,6-lactone + NADPH
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NADH
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NADPH is 145-times as effective as NADH
NADPH
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NADPH is 145-times as effective as NADH
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4
D-galacturonic acid
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6
D-glucuronic acid
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L-iduronic acid
0.045
NADPH
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with D-glucuronic acid
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additional information
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13450 U/min * mg, 1 unit is defined as change of absorbance of 0.01/min at 340 nm
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5.5 - 7.5
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DL-glyceraldehyde
6 - 7
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D-glucuronic acid
9.5
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broad, oxidation of glycerol and L-gulonolactone
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brenda
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brenda
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brenda
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40000
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1 * 40000, SDS-PAGE
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monomer
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1 * 40000, SDS-PAGE
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40
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180 min, 50% loss of activity; 30 min, 20% loss of activity; 60 min, 30% loss of activity
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freezing and thawing: 3 times causes 25% decrease of activity, 5 times causes 40% decrease of activity
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-80°C, 10 days, 30% loss of activity
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0°C, 2 months, less than 10% loss of activity
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A0A2X1FGC4_9BURK
528
56793
TrEMBL
Q63RE4_BURPS
Burkholderia pseudomallei (strain K96243)
505
54737
TrEMBL
A0A1W1A6N7_9BURK
531
57199
TrEMBL
C3KN28_SINFN
Sinorhizobium fredii (strain NBRC 101917 / NGR234)
117
12377
TrEMBL
G8Q002_PSEFL
799
87653
TrEMBL
Q63RE5_BURPS
Burkholderia pseudomallei (strain K96243)
787
84441
TrEMBL
C9YHB1_9BURK
755
81539
TrEMBL
Q3JPB7_BURP1
Burkholderia pseudomallei (strain 1710b)
787
84441
TrEMBL
A0A2X1GQE9_9BURK
531
57256
TrEMBL
J7QMF7_ECOLX
229
24313
TrEMBL
A0A2X2RNB6_BURCE
514
55705
TrEMBL
J7RQ89_ECOLX
229
24313
TrEMBL
B4ECW3_BURCJ
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
787
84879
TrEMBL
Q3JPB6_BURP1
Burkholderia pseudomallei (strain 1710b)
505
54737
TrEMBL
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Hayashi, S.; Watanabe, M.; Kimura, A.
Enzymatic determination of free glucoronic acid with glucuronolactone reductase. I. isolation and purification of glucoronolactone reductase from rat kidney
J. Biochem.
95
223-232
1984
Rattus norvegicus
brenda
Nandi, A.; Chatterjee, I.B.
Interrelation of xanthine oxidase and dehydrogenase and L-gulonolactone oxidase in animal tissue
Indian J. Exp. Biol.
29
574-578
1991
Rattus norvegicus
brenda
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