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Information on EC 1.1.1.193 - 5-amino-6-(5-phosphoribosylamino)uracil reductase for references in articles please use BRENDA:EC1.1.1.193
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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
riboflavin biosynthesis protein,
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aminodioxyphosphoribosylaminopyrimidine reductase
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riboflavin biosynthesis protein
RibD
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riboflavin biosynthesis protein
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riboflavin biosynthesis protein
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5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+ = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+
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5-amino-6-(5-phospho-D-ribitylamino)uracil:NADP+ 1'-oxidoreductase
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5-amino-2,6-dioxy-4-(5'-phosphoribosylamino)pyrimidine + NADPH
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NADP+
5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
additional information
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5-amino-2,6-dioxy-4-(5'-phosphoribosylamino)pyrimidine + NADPH
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NADP+
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intermediate in the biosynthesis of riboflavin
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5-amino-2,6-dioxy-4-(5'-phosphoribosylamino)pyrimidine + NADPH
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NADP+
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intermediate in the biosynthesis of riboflavin
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5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
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5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
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5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
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5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
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additional information
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the enzyme is involved in riboflavin biosynthesis, overview
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additional information
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the enzyme is involved in riboflavin biosynthesis, overview
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additional information
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the enzyme is involved in riboflavin biosynthesis, overview
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5-amino-2,6-dioxy-4-(5'-phosphoribosylamino)pyrimidine + NADPH
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NADP+
5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
additional information
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5-amino-2,6-dioxy-4-(5'-phosphoribosylamino)pyrimidine + NADPH
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NADP+
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intermediate in the biosynthesis of riboflavin
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5-amino-2,6-dioxy-4-(5'-phosphoribosylamino)pyrimidine + NADPH
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NADP+
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intermediate in the biosynthesis of riboflavin
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5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
P17618
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5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
P25539
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5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
Q2VCF5
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5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADPH + H+
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NADP+
Q2VCF5
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additional information
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Q2VCF5
the enzyme is involved in riboflavin biosynthesis, overview
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additional information
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the enzyme is involved in riboflavin biosynthesis, overview
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additional information
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Q2VCF5
the enzyme is involved in riboflavin biosynthesis, overview
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NADH
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NADH
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30% as effective as NADPH
NADPH
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Mg2+
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8
assay at
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37
assay at
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putative
UniProt
brenda
gene ribG or ribD
UniProt
brenda
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bifunctional enzyme; gene ribG
UniProt
brenda
bifunctional enzyme; gene ribG
UniProt
brenda
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brenda
gene ribD or ribG
UniProt
brenda
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brenda
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brenda
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Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)
Bacillus subtilis (strain 168)
Escherichia coli (strain K12)
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)
Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
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22000
x * 22000, recombinant enzyme, SDS-PAGE
40000
2 * 42038, calculated, 2 * 40000, SDS-PAGE, tagged recombinant protein
42038
2 * 42038, calculated, 2 * 40000, SDS-PAGE, tagged recombinant protein
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x * 22000, recombinant enzyme, SDS-PAGE
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x * 22000, recombinant enzyme, SDS-PAGE
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dimer
2 * 42038, calculated, 2 * 40000, SDS-PAGE, tagged recombinant protein
dimer
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2 * 42038, calculated, 2 * 40000, SDS-PAGE, tagged recombinant protein
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additional information
domain structure, overview
additional information
domain structure, overview
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orthorhombic and tetragonal crystal forms at 2.2 and 2.0 A resolution
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additional information
a ribG mutant can be rescued by expression of ribB, overview
additional information
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a ribG mutant can be rescued by expression of ribB, overview
additional information
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a ribG mutant can be rescued by expression of ribB, overview
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-6°C, 50 mM Tris-HCl, pH 8.0, 1 month
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recombinant enzyme from Escherichia coli to homogeneity
recombinant enzyme from Escherichia coli to homogeneity
recombinant enzyme from Escherichia coli to homogeneity
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gene ribD, i.e. ribG, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3)
gene ribG, i.e. ribD, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3)
gene ribG, ribG forms an expression unit with ribY, a monofunctional GTP cyclohydrolase II, DNA and amino acid sequence determination and analysis, overexpression in Escherichia coli strain BL21(DE3)
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Richter, G.; Fischer, M.; Krieger, C.; Eberhardt, S.; Luttgen, H.; Gerstenschläger, I.; Bacher, A.
Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis
J. Bacteriol.
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2022-2028
1997
Bacillus subtilis (P17618), Escherichia coli (P25539)
brenda
Burrows, R.B.; Brown, G.M.
Presence in Escherichia coli of a deaminase and a reductase involved in biosynthesis of riboflavin
J. Bacteriol.
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657-667
1978
Escherichia coli, Escherichia coli B / ATCC 11303
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Grill, S.; Yamaguchi, H.; Wagner, H.; Zwahlen, L.; Kusch, U.; Mack, M.
Identification and characterization of two Streptomyces davawensis riboflavin biosynthesis gene clusters
Arch. Microbiol.
188
377-387
2007
Streptomyces davaonensis (Q2VCF5), Streptomyces davaonensis, Streptomyces davaonensis 768 (Q2VCF5)
brenda
Dawson, A.; Trumper, P.; Chrysostomou, G.; Hunter, W.N.
Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii
Acta Crystallogr. Sect. F
69
611-617
2013
Acinetobacter baumannii (D0CB74)
brenda
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1.1.1.193 5-amino-6-(5-phosphoribosylamino)uracil reductase
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