Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

for references in articles please use BRENDA:EC1.1.1.176

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

Catalyses the oxidation of the 12α-hydroxy group of bile acids, both in their free and conjugated form. Also acts on bile alcohols.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
12alpha-hydroxysteroid dehydrogenase, 12alpha-hsdh, nad-dependent 12alpha-hydroxysteroid dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cholate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate + NADPH + H+
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
bile acids 12-O-epimerization
Highest Expressing Human Cell Lines
Cell Line Links Gene Links