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Information on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

for references in articles please use BRENDA:EC1.1.1.153
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IUBMB Comments
This enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. cf. EC 1.1.1.325, sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming).
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
akr1b1, sepiapterin reductase, mdspr, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-erythro-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+
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L-erythro-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+
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