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11beta,17-dihydroxy-pregn-4,11-diene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4,11-diene-3,20-dione + NAD+
-
i.e. 21-dehydro-delta1-cortisol, only NAD dehydrogenase II
i.e. 21-hydroxy-delta1-cortisol
?
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
11beta-hydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,21-dihydroxy-pregn-4-ene-3,20-dione + NAD+
-
i.e. 21-dehydrocorticosterone, only NAD dehydrogenase II
i.e. 21-hydroxycorticosterone
?
17-hydroxy-pregn-4-ene-3,11,20,21-tetraone + NADH
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NAD+
-
i.e. 21-dehydrocortisone
i.e. cortisone
?
17-hydroxy-pregn-4-ene-3,20,21-trione + NADH
17,21-dihydroxy-pregn-4-ene-3,20-dione + NAD+
-
i.e. 21-dehydro-11-deoxycortisol, only NAD dehydrogenase II
i.e. 21-hydroxy-11-deoxycortisol
?
5beta-pregnane-3alpha,21-diol-20-one + NAD+
5beta-pregnane-3alpha-ol-20,21-dione + NADH + H+
dihydrotestosterone + NADH
androstanediol + NAD+
-
substrate for retinol dehydrogenase isoform RDH12, no substrate for isoform RDH13
-
-
?
pregn-4-ene-3,20,21-trione + NADH
21-hydroxy-pregn-4-ene-3,20-dione + NAD+
-
i.e. 21-dehydro-11-deoxycorticosterone, only NAD dehydrogenase II
i.e. 21-hydroxy-11-deoxycorticosterone
?
additional information
?
-
-
contrary to the human enzyme, dihydrotestosterone is not a substrate for mouse retinol dehydrogenase isoform RDH12
-
-
?
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
-
-
i.e. cortisol
?
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
-
i.e. 21-dehydrocortisol, transfer of the hydrogen to the 21-pro-S position of cortisol
-
?
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+
-
i.e. 21-dehydrocortisol, transfer of the hydrogen to the 21-pro-S position of cortisol
-
?
5beta-pregnane-3alpha,21-diol-20-one + NAD+
5beta-pregnane-3alpha-ol-20,21-dione + NADH + H+
-
selective for the pro-S position
-
?
5beta-pregnane-3alpha,21-diol-20-one + NAD+
5beta-pregnane-3alpha-ol-20,21-dione + NADH + H+
-
selective for the pro-S position
-
?
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0.172
11beta,17-dihydroxy-pregn-4,11-diene-3,20,21-trione
-
NAD dehydrogenase II
0.182
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione
-
-
0.105
11beta-hydroxy-pregn-4-ene-3,20,21-trione
-
NAD dehydrogenase II
0.221
17-hydroxy-pregn-4-ene-3,11,20,21-tetraone
-
-
0.111
17-hydroxy-pregn-4-ene-3,20,21-trione
-
NAD dehydrogenase II
0.174
pregn-4-ene-3,20,21-trione
-
NAD dehydrogenase II
0.01
NADH
-
NAD dehydrogenase I
0.048
NADH
-
NAD dehydrogenase II
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Monder, C.; White, A.
The 21-hydroxysteroid dehydrogenases of liver. A nicotinamide adenine dinucleotide phosphate dehydrogenase and two nicotinamide adenine dinucleotide dehydrogenases
J. Biol. Chem.
240
71-77
1965
Ovis aries aries
brenda
Orr, J.C.; Monder, C.
The stereospecificity of the enzymatic reduction of 21-dehydrocortisol by NADH
J. Biol. Chem.
250
7547-7553
1975
Ovis aries aries
brenda
Orr, J.C.; Monder, C.
The stereochemistry of enzymatic reduction of 21-dehydrocortisol to cortisol
J. Steroid Biochem.
6
297-299
1975
Ovis aries aries
brenda
Holland, H.L.; Ninniss, R.W.; Brown, F.M.
Stereochemistry of hydrogen loss during C-21 dehydroxylation of tetrahydrodeoxycorticosterone by Eubacterium lentum
Can. J. Chem.
67
1590-1595
1989
Bos taurus, Eggerthella lenta
-
brenda
Keller, B.; Adamski, J.
RDH12, a retinol dehydrogenase causing Lebers congenital amaurosis, is also involved in steroid metabolism
J. Steroid Biochem. Mol. Biol.
104
190-194
2007
Homo sapiens, Mus musculus
brenda
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Enzyme Nomenclature
1.1.1.150 21-hydroxysteroid dehydrogenase (NAD+)
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