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Re-specific with respect to NAD(P)+ (cf. EC 22.214.171.124 17beta-estradiol 17-dehydrogenase).
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, AKR1C1, AKR1C23, more