Information on EC 1.1.1.137 - ribitol-5-phosphate 2-dehydrogenase

for references in articles please use BRENDA:EC1.1.1.137
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The expected taxonomic range for this enzyme is: Lactobacillus

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EC NUMBER
COMMENTARY hide
1.1.1.137
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RECOMMENDED NAME
GeneOntology No.
ribitol-5-phosphate 2-dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
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redox reaction
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-
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reduction
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Pentose and glucuronate interconversions
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Metabolic pathways
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-
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SYSTEMATIC NAME
IUBMB Comments
D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase
The enzyme, characterized from the bacterium Lactobacillus plantarum, can use both NAD+ and NADP+ as electron acceptor [cf. EC 1.1.1.405, ribitol-5-phosphate 2-dehydrogenase (NADP+)].
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CAS REGISTRY NUMBER
COMMENTARY hide
37250-67-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Bacillus subtilis
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-ribitol 5-phosphate + NAD(P)+
D-ribulose 5-phosphate + NAD(P)H + H+
show the reaction diagram
D-ribitol 5-phosphate + NAD+
D-ribulose 5-phosphate + NADH
show the reaction diagram
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r
D-ribulose 5-phosphate + NADH + H+
D-ribitol 5-phosphate + NAD+
show the reaction diagram
D-ribulose 5-phosphate + NADPH + H+
D-ribitol 5-phosphate + NADP+
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-ribitol 5-phosphate + NAD(P)+
D-ribulose 5-phosphate + NAD(P)H + H+
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
-
cofactor
NADP+
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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no increase in enzyme activity is observed when 25 mM Mg2+ or Mn2+ is added to the EDTA-containing assay mixture
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
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complete inhibition at 50 mM, the enzyme activity can be restored by adding 25 mM Zn2+
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.66
D-ribitol 5-phosphate
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0.15
D-ribulose 5-phosphate
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0.025
NAD+
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
76.8
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at pH 7.4, temperature not specified in the publication
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 6.5
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D-ribitol 5-phosphate + NAD+
8 - 9
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D-ribulose 5-phosphate + NADH
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
49000
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2 * 49000, denaturing PAGE
115000
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gel filtration
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
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2 * 49000, denaturing PAGE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20�C, lyophilized powder, stable for 3 weeks
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frozen, stable for at least a week
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.137)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)