Information on EC 1.1.1.110 - indolelactate dehydrogenase

for references in articles please use BRENDA:EC1.1.1.110
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The expected taxonomic range for this enzyme is: Clostridium sporogenes

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EC NUMBER
COMMENTARY hide
1.1.1.110
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RECOMMENDED NAME
GeneOntology No.
indolelactate dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(indol-3-yl)lactate + NAD+ = (indol-3-yl)pyruvate + NADH + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
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redox reaction
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-
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reduction
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
4-hydroxybenzoate biosynthesis I (eukaryotes)
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L-phenylalanine degradation IV (mammalian, via side chain)
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L-phenylalanine degradation VI (Stickland reaction)
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L-tryptophan degradation IV (via indole-3-lactate)
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L-tryptophan degradation XIII (Stickland reaction)
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L-tyrosine degradation V (Stickland reaction)
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tryptophan metabolism
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Tryptophan metabolism
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SYSTEMATIC NAME
IUBMB Comments
(indol-3-yl)lactate:NAD+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37250-41-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
indoleglycolate + NAD+
indoleglyoxylate + NADH
show the reaction diagram
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-
-
r
indolelactate + NAD+
indolepyruvate + NADH
show the reaction diagram
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-
-
r
p-hydroxyphenyllactate + NAD+
p-hydroxyphenylpyruvate + NADH
show the reaction diagram
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-
-
r
phenyllactate + NAD+
phenylpyruvate + NADH
show the reaction diagram
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-
-
r
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
indolelactate + NAD+
indolepyruvate + NADH
show the reaction diagram
-
-
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r
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.691
indoleglycolate
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1.03
indolelactate
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0.0142
NADH
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1.77
p-hydroxyphenyllactate
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0.075
p-hydroxyphenylpyruvate
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2.21
Phenyllactate
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0.106
phenylpyruvate
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 8
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indolepyruvate reduction
8 - 9
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indolelactate oxidation
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, 100 mM potassium phosphate, pH 7.5, 1 mM mercaptoethanol, 6 months, no loss of activity, 0°C, 100 mM potassium phosphate, pH 7.5, 1 mM mercaptoethanol, 15 days, no loss of activity
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate, DEAE-cellulose
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.110)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)