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The enzyme, isolated from animals, is specific for 4-oxo-L-proline and cis-4-hydroxy-L-proline. It has no activity with trans-4-hydroxy-L-proline.
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The enzyme appears in viruses and cellular organisms
hydroxy-l-proline oxidase, more
cis-4-hydroxy-L-proline + NAD+ = 4-oxo-L-proline + NADH + H+
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