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Information on EC 1.1.1.104 - 4-oxoproline reductase

for references in articles please use BRENDA:EC1.1.1.104

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EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.104 4-oxoproline reductase

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The expected taxonomic range for this enzyme is: Oryctolagus cuniculus

Reaction Schemes

Synonyms

hydroxy-L-proline oxidase, show all synonyms

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

hydroxy-L-proline oxidase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

oxidation

redox reaction

reduction

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PATHWAY SOURCE

PATHWAYS

KEGG

Arginine and proline metabolism

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SYSTEMATIC NAME

IUBMB Comments

4-hydroxy-L-proline:NAD+ oxidoreductase

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CAS REGISTRY NUMBER

COMMENTARY

37250-37-6

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

4-oxo-proline + NADH

4-hydroxy-L-proline + NAD+

Oryctolagus cuniculus

285722

4-oxoproline + NADH

4-hydroxy-L-proline + NAD+

Oryctolagus cuniculus

285722

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

4-oxo-proline + NADH

4-hydroxy-L-proline + NAD+

Oryctolagus cuniculus

285722

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NADH

Oryctolagus cuniculus

285722

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.6

4-Oxoproline

Oryctolagus cuniculus

285722

0.84

NADH

Oryctolagus cuniculus

285722

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5.21

Oryctolagus cuniculus

285722

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Oryctolagus cuniculus

285722

brenda

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

kidney

Oryctolagus cuniculus

285722

brenda

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-10°C, 160 mM phosphate buffer, pH 6.0, 3 months, no loss of activity

Oryctolagus cuniculus

285722

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

ammonium sulfate, negative alumina gel, positive alumina gel

Oryctolagus cuniculus

285722

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

285722

Smith, T.E.; Mitoma, C.

Partial purification and some properties of 4-ketoproline reductase

J. Biol. Chem.

237

1177-1180

1962

Oryctolagus cuniculus

13914427

brenda

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EXTERNAL LINKS (specific for EC-Number 1.1.1.104)

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

IUBMB Enzyme Nomenclature

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)

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