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Information on EC 1.1.1.1 - alcohol dehydrogenase

for references in articles please use BRENDA:EC1.1.1.1

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IUBMB Comments

A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
adh, alcohol dehydrogenase, aldehyde dehydrogenase, adh1b, short-chain dehydrogenase/reductase, ssadh, adh1c, yeast alcohol dehydrogenase, retinol dehydrogenase, faldh, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a primary alcohol + NAD+ = an aldehyde + NADH + H+
show the reaction diagram
a secondary alcohol + NAD+ = a ketone + NADH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
(S)-propane-1,2-diol degradation, 3-methylbutanol biosynthesis (engineered), acetaldehyde biosynthesis I, acetylene degradation (anaerobic), butanol and isobutanol biosynthesis (engineered), ethanol degradation I, ethanol degradation II, ethanolamine utilization, heterolactic fermentation, L-isoleucine degradation II, L-leucine degradation III, L-methionine degradation III, L-phenylalanine degradation III, L-tryptophan degradation V (side chain pathway), L-tyrosine degradation III, L-valine degradation II, mixed acid fermentation, noradrenaline and adrenaline degradation, phenylethanol biosynthesis, phytol degradation, pyruvate fermentation to ethanol I, pyruvate fermentation to ethanol II, pyruvate fermentation to ethanol III, pyruvate fermentation to isobutanol (engineered), salidroside biosynthesis, serotonin degradation, superpathway of fermentation (Chlamydomonas reinhardtii)