EC Explorer

7.6.2.3

ABC-type glutathione-S-conjugate transporter

ATP + H₂O + glutathione-S-conjugate_{[side 1]} = ADP + phosphate + glutathione-S-conjugate_{[side 2]}

multidrug resistance-associated protein 1, glutathione-S-conjugate-translocating ATPase, MRP, MRP1, ABCC1 (gene name), YBT1 (gene name), YCF1 (gene name)

ATP phosphohydrolase (ABC-type, glutathione-S-conjugate-exporting)

A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.

created 2018