EC Explorer

7.6.2.2

ABC-type xenobiotic transporter

ATP + H₂O + xenobiotic_{[side 1]} = ADP + phosphate + xenobiotic_{[side 2]}

xenobiotic-transporting ATPase, multidrug-resistance protein, MDR protein, P-glycoprotein, pleiotropic-drug-resistance protein, PDR protein, steroid-transporting ATPase, ATP phosphohydrolase (steroid-exporting)

ATP phosphohydrolase (ABC-type, xenobiotic-exporting)

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them also transport glutathione—drug conjugates (see EC 7.6.2.3, ABC-type glutathione-S-conjugate transporter) while others also show some ’flippase’ activity (cf. EC 7.6.2.1, P-type phospholipid transporter).

created 2000 as EC 3.6.3.44 (EC 3.6.3.45 incorporated 2006), modified 2006, transferred 2018 to EC 7.6.2.2