EC Explorer

EC 7.1.1.2 Details
show Brenda entry
EC number
7.1.1.2
Accepted name
NADH:ubiquinone reductase (H+-translocating)
Reaction
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
Other name(s)
ubiquinone reductase (ambiguous), type 1 dehydrogenase, complex 1 dehydrogenase, coenzyme Q reductase (ambiguous), complex I (electron transport chain), complex I (mitochondrial electron transport), complex I (NADH:Q1 oxidoreductase), dihydronicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous), DPNH-coenzyme Q reductase (ambiguous), DPNH-ubiquinone reductase (ambiguous), mitochondrial electron transport complex 1, mitochondrial electron transport complex I, NADH coenzyme Q1 reductase, NADH-coenzyme Q oxidoreductase (ambiguous), NADH-coenzyme Q reductase (ambiguous), NADH-CoQ oxidoreductase (ambiguous), NADH-CoQ reductase (ambiguous), NADH-ubiquinone reductase (ambiguous), NADH-ubiquinone oxidoreductase (ambiguous), NADH-ubiquinone-1 reductase, reduced nicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous), NADH:ubiquinone oxidoreductase complex, NADH-Q6 oxidoreductase (ambiguous), electron transfer complex I, NADH2 dehydrogenase (ubiquinone)
Systematic name
NADH:ubiquinone oxidoreductase
CAS registry number
9028-04-0
Comment
A flavoprotein (FMN) containing iron-sulfur clusters. The complex is present in mitochondria and aerobic bacteria. Breakdown of the complex can release EC 1.6.99.3, NADH dehydrogenase. In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD+ to NADH.
History
created 1961 as EC 1.6.5.3, deleted 1965, reinstated 1983, modified 2011, modified 2013, transferred 2018 to EC 7.1.1.2