EC Explorer

7.1.1.1

proton-translocating NAD(P)⁺ transhydrogenase

NADPH + NAD⁺ + H⁺_{[side 1]} = NADP⁺ + NADH + H⁺_{[side 2]}

pntA (gene name), pntB (gene name), NNT (gene name)

NADPH:NAD⁺ oxidoreductase (H⁺-transporting)

The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme.

created 2015 as EC 1.6.1.5, transferred 2018 to EC 7.1.1.1