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EC number
Accepted name
proton-translocating NAD(P)+ transhydrogenase
NADPH + NAD+ + H+[side 1] = NADP+ + NADH + H+[side 2]
Other name(s)
pntA (gene name), pntB (gene name), NNT (gene name)
Systematic name
NADPH:NAD+ oxidoreductase (H+-transporting)
The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme.
created 2015 as EC, transferred 2018 to EC