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EC 6.3.2.2 Details
EC number
6.3.2.2
Accepted name
glutamate—cysteine ligase
Reaction
ATP + L-glutamate + L-cysteine = ADP + phosphate + γ-L-glutamyl-L-cysteine
Other name(s)
γ-glutamylcysteine synthetase, γ-glutamyl-L-cysteine synthetase, γ-glutamylcysteinyl synthetase
Systematic name
L-glutamate:L-cysteine γ-ligase (ADP-forming)
CAS registry number
9023-64-7
Comment
Can use L-aminohexanoate in place of glutamate.
History
created 1961
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
6.1 Forming carbon-oxygen bonds
6.2 Forming carbon-sulfur bonds
6.3 Forming carbon-nitrogen bonds
6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
6.3.2 Acid—amino-acid ligases (peptide synthases)
6.3.2.1 pantoate—β-alanine ligase (AMP-forming)
6.3.2.2 glutamate—cysteine ligase
6.3.2.3 glutathione synthase
6.3.2.4 D-alanine—D-alanine ligase
6.3.2.5 phosphopantothenate—cysteine ligase (CTP)
6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase
6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
6.3.2.8 UDP-N-acetylmuramate—L-alanine ligase
6.3.2.9 UDP-N-acetylmuramoyl-L-alanine—D-glutamate ligase
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
6.3.2.11 carnosine synthase
6.3.2.12 dihydrofolate synthase
6.3.2.13 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase
6.3.2.14 enterobactin synthase
6.3.2.15 created 1976, deleted 2002
6.3.2.16 D-alanine—alanyl-poly(glycerolphosphate) ligase
6.3.2.17 tetrahydrofolate synthase
6.3.2.18 γ-glutamylhistamine synthase
6.3.2.19 ubiquitin—protein ligase
6.3.2.20 indoleacetate—lysine synthetase
6.3.2.21 ubiquitin—calmodulin ligase
6.3.2.22 diphthine—ammonia ligase
6.3.2.23 homoglutathione synthase
6.3.2.24 tyrosine—arginine ligase
6.3.2.25 tubulin—tyrosine ligase
6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
6.3.2.27 aerobactin synthase
6.3.2.28 L-amino-acid α-ligase
6.3.2.29 cyanophycin synthase (L-aspartate-adding)
6.3.2.30 cyanophycin synthase (L-arginine-adding)
6.3.2.31 coenzyme F420-0:L-glutamate ligase
6.3.2.32 coenzyme γ-F420-2:α-L-glutamate ligase
6.3.2.33 tetrahydrosarcinapterin synthase
6.3.2.34 coenzyme F420-1:γ-L-glutamate ligase
6.3.2.35 D-alanine—D-serine ligase
6.3.2.36 4-phosphopantoate—β-alanine ligase
6.3.2.37 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase
6.3.2.39 aerobactin synthase
6.3.2.40 cyclopeptine synthase
6.3.2.41 N-acetylaspartylglutamate synthase
6.3.2.42 N-acetylaspartylglutamylglutamate synthase
6.3.2.43 [amino-group carrier protein]—L-2-aminoadipate ligase
6.3.2.44 pantoate—β-alanine ligase (ADP-forming)
6.3.2.45 UDP-N-acetylmuramate—L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate ligase
6.3.2.46 fumarate—(S)-2,3-diaminopropanoate ligase
6.3.2.47 dapdiamide synthase
6.3.2.48 L-arginine-specific L-amino acid ligase
6.3.2.49 L-alanine—L-anticapsin ligase
6.3.2.50 tenuazonic acid synthetase
6.3.2.51 phosphopantothenate—cysteine ligase (ATP)
6.3.2.52 jasmonoyl—L-amino acid ligase
6.3.2.53 UDP-N-acetylmuramoyl-L-alanine—L-glutamate ligase
6.3.2.54 L-2,3-diaminopropanoate—citrate ligase
6.3.2.55 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
6.3.2.56 staphyloferrin B synthase
6.3.2.57 staphyloferrin A synthase
6.3.2.58 D-ornithine—citrate ligase
6.3.2.59 3-methyl-D-ornithine—L-lysine ligase
6.3.2.60 glutamate—[amino group carrier protein] ligase
6.3.2.61 tubulin-glutamate ligase
6.3.2.62 β-tubulin-glutamate ligase
6.3.3 Cyclo-ligases
6.3.4 Other carbon-nitrogen ligases
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.4 Forming carbon-carbon bonds
6.5 Forming phosphoric-ester bonds
6.6 Forming nitrogen—metal bonds
6.7 Forming nitrogen-nitrogen bonds
7 Translocases