EC Explorer

5.4.3.3

lysine 5,6-aminomutase

(1) (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate;;(2) D-lysine = (2R,5S)-2,5-diaminohexanoate

β-lysine 5,6-aminomutase, β-lysine mutase, L-β-lysine 5,6-aminomutase, D-lysine 5,6-aminomutase, D-α-lysine mutase, adenosylcobalamin-dependent D-lysine 5,6-aminomutase

(3S)-3,6-diaminohexanoate 5,6-aminomutase

9075-69-8

This enzyme is a member of the ‘AdoMet radical’ (radical SAM) family. It requires pyridoxal 5′-phosphate and adenosylcobalamin for activity. A 5′-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of adenosylcobalamin, which is regenerated at the end of the reaction.

created 1972 (EC 5.4.3.4 created 1972, incorporated 2017), modified 2017