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EC 4.2.3.12 Details
EC number
4.2.3.12
Accepted name
6-pyruvoyltetrahydropterin synthase
Reaction
7,8-dihydroneopterin 3′-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
Other name(s)
2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase, 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)
Systematic name
7,8-dihydroneopterin 3′-triphosphate triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)
CAS registry number
97089-82-2
Comment
Catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. It has been identified in human liver. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 3.5.4.16 (GTP cyclohydrolase I) [3].
History
created 1999 as EC 4.6.1.10, transferred 2000 to EC 4.2.3.12, modified 2001
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