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EC 3.6.4.6 Details

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EC number

3.6.4.6

Accepted name

vesicle-fusing ATPase

Reaction

ATP + H₂O = ADP + phosphate

Systematic name

ATP phosphohydrolase (vesicle-fusing)

Comment

A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger’s syndrome.

History

created 2000

EC Tree

1 Oxidoreductases

2 Transferases

3 Hydrolases

3.1 Acting on ester bonds

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.2 In sulfonyl-containing anhydrides

3.6.3 Acting on acid anhydrides to catalyse transmembrane movement of substances

3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement

3.6.4.1 myosin ATPase

3.6.4.2 dynein ATPase

3.6.4.3 microtubule-severing ATPase

3.6.4.4 plus-end-directed kinesin ATPase

3.6.4.5 minus-end-directed kinesin ATPase

3.6.4.6 vesicle-fusing ATPase

3.6.4.7 peroxisome-assembly ATPase

3.6.4.8 proteasome ATPase

3.6.4.9 chaperonin ATPase

3.6.4.10 non-chaperonin molecular chaperone ATPase

3.6.4.11 nucleoplasmin ATPase

3.6.4.12 DNA helicase

3.6.4.13 RNA helicase

3.6.5 Acting on GTP to facilitate cellular and subcellular movement

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds