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EC 3.4.21.6 Details
EC number
3.4.21.6
Accepted name
coagulation factor Xa
Reaction
Selective cleavage of Arg┼Thr and then Arg┼Ile bonds in prothrombin to form thrombin
Other name(s)
thrombokinase, prothrombase, prothrombinase, activated blood-coagulation factor X, autoprothrombin C, thromboplastin, plasma thromboplastin, factor Xa, activated Stuart-Prower factor, activated factor X
CAS registry number
9002-05-5
Comment
A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
History
created 1972, modified 2011
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.4.1 α-Amino-acyl-peptide hydrolases (deleted sub-subclass)
3.4.2 Peptidyl-amino-acid hydrolases (deleted sub-subclass)
3.4.3 Dipeptide hydrolases (deleted sub-subclass)
3.4.4 Peptidyl peptide hydrolases (deleted sub-subclass)
3.4.11 Aminopeptidases
3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)
3.4.13 Dipeptidases
3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
3.4.15 Peptidyl-dipeptidases
3.4.16 Serine-type carboxypeptidases
3.4.17 Metallocarboxypeptidases
3.4.18 Cysteine-type carboxypeptidases
3.4.19 Omega peptidases
3.4.21 Serine endopeptidases
3.4.21.1 chymotrypsin
3.4.21.2 chymotrypsin C
3.4.21.3 metridin
3.4.21.4 trypsin
3.4.21.5 thrombin
3.4.21.6 coagulation factor Xa
3.4.21.7 plasmin
3.4.21.8 created 1972, deleted 1981
3.4.21.9 enteropeptidase
3.4.21.10 acrosin
3.4.21.11 created 1972, deleted 1981
3.4.21.12 α-lytic endopeptidase
3.4.21.13 created 1972, deleted 1978
3.4.21.14 created 1961 as EC 3.4.4.16, transferred 1972 to EC 3.4.21.14, modified 1986, deleted 1992
3.4.21.15 created 1972, deleted 1978 (transferred to EC 3.4.21.14, deleted 1992)
3.4.21.16 created 1972, deleted 1992
3.4.21.17 created 1972, deleted 1978 [transferred to EC 3.4.21.14, deleted 1992]
3.4.21.18 created 1972 [EC 3.4.99.24 created 1972, incorporated 1978], deleted 1992
3.4.21.19 glutamyl endopeptidase
3.4.21.20 cathepsin G
3.4.21.21 coagulation factor VIIa
3.4.21.22 coagulation factor IXa
3.4.21.23 created 1978, deleted 1992
3.4.21.24 created 1978, deleted 1992
3.4.21.25 cucumisin
3.4.21.26 prolyl oligopeptidase
3.4.21.27 coagulation factor XIa
3.4.21.28 created 1978, deleted 1992
3.4.21.29 created 1978, deleted 1992
3.4.21.30 created 1978, deleted 1992
3.4.21.31 created 1972 as EC 3.4.99.26, transferred 1978 to EC 3.4.21.31, deleted 1992
3.4.21.32 brachyurin
3.4.21.33 created 1978, deleted 1992
3.4.21.34 plasma kallikrein
3.4.21.35 tissue kallikrein
3.4.21.36 pancreatic elastase
3.4.21.37 leukocyte elastase
3.4.21.38 coagulation factor XIIa
3.4.21.39 chymase
3.4.21.40 created 1981, deleted 1992
3.4.21.41 complement subcomponent C1r
3.4.21.42 complement subcomponent C1s
3.4.21.43 classical-complement-pathway C3/C5 convertase
3.4.21.44 created 1981, deleted 1984
3.4.21.45 complement factor I
3.4.21.46 complement factor D
3.4.21.47 alternative-complement-pathway C3/C5 convertase
3.4.21.48 cerevisin
3.4.21.49 hypodermin C
3.4.21.50 lysyl endopeptidase
3.4.21.51 created 1984, deleted 1992
3.4.21.52 created 1981 as EC 3.4.99.33, transferred 1984 to EC 3.4.21.52, deleted 1992
3.4.21.53 endopeptidase La
3.4.21.54 γ-renin
3.4.21.55 venombin AB
3.4.21.56 created 1972 as EC 3.4.99.7, transferred 1989 to EC 3.4.21.56, deleted 1992
3.4.21.57 leucyl endopeptidase
3.4.21.58 created 1989, deleted 1992
3.4.21.59 tryptase
3.4.21.60 scutelarin
3.4.21.61 kexin
3.4.21.62 subtilisin
3.4.21.63 oryzin
3.4.21.64 peptidase K
3.4.21.65 thermomycolin
3.4.21.66 thermitase
3.4.21.67 endopeptidase So
3.4.21.68 t-plasminogen activator
3.4.21.69 protein C (activated)
3.4.21.70 pancreatic endopeptidase E
3.4.21.71 pancreatic elastase II
3.4.21.72 IgA-specific serine endopeptidase
3.4.21.73 u-plasminogen activator
3.4.21.74 venombin A
3.4.21.75 furin
3.4.21.76 myeloblastin
3.4.21.77 semenogelase
3.4.21.78 granzyme A
3.4.21.79 granzyme B
3.4.21.80 streptogrisin A
3.4.21.81 streptogrisin B
3.4.21.82 glutamyl endopeptidase II
3.4.21.83 oligopeptidase B
3.4.21.84 limulus clotting factor C
3.4.21.85 limulus clotting factor B
3.4.21.86 limulus clotting enzyme
3.4.21.87 omptin
3.4.21.88 repressor LexA
3.4.21.89 signal peptidase I
3.4.21.90 togavirin
3.4.21.91 flavivirin
3.4.21.92 endopeptidase Clp
3.4.21.93 proprotein convertase 1
3.4.21.94 proprotein convertase 2
3.4.21.95 snake venom factor V activator
3.4.21.96 lactocepin
3.4.21.97 assemblin
3.4.21.98 hepacivirin
3.4.21.99 spermosin
3.4.21.100 sedolisin
3.4.21.101 xanthomonalisin
3.4.21.102 C-terminal processing peptidase
3.4.21.103 physarolisin
3.4.21.104 mannan-binding lectin-associated serine protease-2
3.4.21.105 rhomboid protease
3.4.21.106 hepsin
3.4.21.107 peptidase Do
3.4.21.108 HtrA2 peptidase
3.4.21.109 matriptase
3.4.21.110 C5a peptidase
3.4.21.111 aqualysin 1
3.4.21.112 site-1 protease
3.4.21.113 pestivirus NS3 polyprotein peptidase
3.4.21.114 equine arterivirus serine peptidase
3.4.21.115 infectious pancreatic necrosis birnavirus Vp4 peptidase
3.4.21.116 SpoIVB peptidase
3.4.21.117 stratum corneum chymotryptic enzyme
3.4.21.118 kallikrein 8
3.4.21.119 kallikrein 13
3.4.21.120 oviductin
3.4.21.121 Lys-Lys/Arg-Xaa endopeptidase
3.4.21.122 transmembrane protease serine 2
3.4.22 Cysteine endopeptidases
3.4.23 Aspartic endopeptidases
3.4.24 Metalloendopeptidases
3.4.25 Threonine endopeptidases
3.4.99 Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases