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EC 2.1.1.226 Details
EC number
2.1.1.226
Accepted name
23S rRNA (cytidine1920-2′-O)-methyltransferase
Reaction
S-adenosyl-L-methionine + cytidine1920 in 23S rRNA = S-adenosyl-L-homocysteine + 2′-O-methylcytidine1920 in 23S rRNA
Other name(s)
TlyA (ambiguous)
Systematic name
S-adenosyl-L-methionine:23S rRNA (cytidine1920-2′-O)-methyltransferase
Comment
The bifunctional enzyme from Mycobacterium tuberculosis 2′-O-methylates cytidine1920 in helix 69 of 23S rRNA and cytidine1409 in helix 44 of 16S rRNA (cf. EC 2.1.1.227, 16S rRNA (cytidine1409-2′-O)-methyltransferase). These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin.
History
created 2011
EC Tree
2.1.1.23 created 1972, modified 1976, modified 1983, deleted 1999
2.1.1.24 created 1972, modified 1983, modified 1989, deleted 1992
2.1.1.30 created 1972, deleted 1981
2.1.1.58 created 1981, deleted 1984
2.1.1.73 created 1984, deleted 2003
2.1.1.81 created 1989, deleted 1990
2.1.1.134 created 1999, deleted 2002
2.1.1.135 created 1999, deleted 2003
2.1.1.138 created 2000, deleted 2003