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EC 1.3.98.1 Details
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EC number
1.3.98.1
Accepted name
dihydroorotate dehydrogenase (fumarate)
Reaction
(S)-dihydroorotate + fumarate = orotate + succinate
Other name(s)
DHOdehase (ambiguous), dihydroorotate dehydrogenase (ambiguous), dihydoorotic acid dehydrogenase (ambiguous), DHOD (ambiguous), DHODase (ambiguous), dihydroorotate oxidase, pyr4 (gene name)
Systematic name
(S)-dihydroorotate:fumarate oxidoreductase
CAS registry number
9029-03-2
Comment
Binds FMN. The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. Molecular oxygen can replace fumarate in vitro. Other class 1 dihydroorotate dehydrogenases use either NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
History
created 1961 as EC 1.3.3.1, transferred 2011 to EC 1.3.98.1
EC Browser
1 Oxidoreductases (9631 organisms) download 3945229 sequences with EC number 1 in fasta format download 3945229 sequences with EC number 1 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 1) as tabstop separated file
2 Transferases (7171 organisms) download 11113840 sequences with EC number 2 in fasta format download 11113840 sequences with EC number 2 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 2) as tabstop separated file
3 Hydrolases (11482 organisms) download 5568323 sequences with EC number 3 in fasta format download 5568323 sequences with EC number 3 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 3) as tabstop separated file
4 Lyases (5139 organisms) download 2953905 sequences with EC number 4 in fasta format download 2953905 sequences with EC number 4 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 4) as tabstop separated file
5 Isomerases (2099 organisms) download 1799417 sequences with EC number 5 in fasta format download 1799417 sequences with EC number 5 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 5) as tabstop separated file
6 Ligases (1565 organisms) download 2708260 sequences with EC number 6 in fasta format download 2708260 sequences with EC number 6 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 6) as tabstop separated file
7 Translocases (1096 organisms) download 2586094 sequences with EC number 7 in fasta format download 2586094 sequences with EC number 7 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 7) as tabstop separated file