EC Explorer

EC 1.3.1.1 Details
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EC number
1.3.1.1
Accepted name
dihydropyrimidine dehydrogenase (NAD+)
Reaction
(1) 5,6-dihydrouracil + NAD+ = uracil + NADH + H+;;(2) 5,6-dihydrothymine + NAD+ = thymine + NADH + H+
Other name(s)
dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, pyrimidine reductase, thymine reductase, uracil reductase, dihydrouracil dehydrogenase (NAD+)
Systematic name
5,6-dihydropyrimidine:NAD+ oxidoreductase
CAS registry number
9026-89-5
Comment
An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth [1]. Since then the enzyme was found in additional organisms including Alcaligenes eutrophus [2], Pseudomonas strains [3,4] and Escherichia coli [5,6].
History
created 1961, modified 2011
EC Browser
1 Oxidoreductases (9631 organisms) download 3945229 sequences with EC number 1 in fasta format download 3945229 sequences with EC number 1 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 1) as tabstop separated file
1.3.1.23 created 1972, deleted 2005 show the reaction
1.3.1.50 created 1992, deleted 1999 show the reaction
1.3.1.55 created 1999, deleted 2004 show the reaction
2 Transferases (7171 organisms) download 11113840 sequences with EC number 2 in fasta format download 11113840 sequences with EC number 2 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 2) as tabstop separated file
3 Hydrolases (11482 organisms) download 5568323 sequences with EC number 3 in fasta format download 5568323 sequences with EC number 3 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 3) as tabstop separated file
4 Lyases (5139 organisms) download 2953905 sequences with EC number 4 in fasta format download 2953905 sequences with EC number 4 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 4) as tabstop separated file
5 Isomerases (2099 organisms) download 1799417 sequences with EC number 5 in fasta format download 1799417 sequences with EC number 5 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 5) as tabstop separated file
6 Ligases (1565 organisms) download 2708260 sequences with EC number 6 in fasta format download 2708260 sequences with EC number 6 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 6) as tabstop separated file
7 Translocases (1096 organisms) download 2586094 sequences with EC number 7 in fasta format download 2586094 sequences with EC number 7 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 7) as tabstop separated file