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EC 1.10.3.15 Details

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EC number

1.10.3.15

Accepted name

grixazone synthase

Reaction

2 3-amino-4-hydroxybenzoate + N-acetyl-L-cysteine + 2 O₂ = grixazone B + 4 H₂O + CO₂

Other name(s)

GriF

Systematic name

3-amino-4-hydroxybenzoate:N-acetyl-L-cysteine:oxygen oxidoreductase

Comment

A type 3 multi copper protein. The enzyme, isolated from the bacterium Streptomyces griseus, catalyses an 8 electron oxidation. Activation of the enzyme requires a copper chaperone (GriE). It also acts on 3-amino-4-hydroxybenzaldehyde, giving grixazone A. The second aldehyde group is presumably lost as formate. The enzyme also catalyses the reaction of EC 1.10.3.4 o-aminophenol oxidase.

History

created 2014

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.10.1 With NAD⁺ or NADP⁺ as acceptor

1.10.2 With a cytochrome as acceptor

1.10.3 With oxygen as acceptor

1.10.3.1 catechol oxidase

1.10.3.2 laccase

1.10.3.3 L-ascorbate oxidase

1.10.3.4 o-aminophenol oxidase

1.10.3.5 3-hydroxyanthranilate oxidase

1.10.3.6 rifamycin-B oxidase

1.10.3.7 created 1986, deleted 2002

1.10.3.8 created 1986, deleted 2002

1.10.3.9 photosystem II

1.10.3.10 ubiquinol oxidase (H⁺-transporting)

1.10.3.11 ubiquinol oxidase (non-electrogenic)

1.10.3.12 menaquinol oxidase (H⁺-transporting)

1.10.3.13 caldariellaquinol oxidase (H⁺-transporting)

1.10.3.14 ubiquinol oxidase (electrogenic, non H⁺-transporting)

1.10.3.15 grixazone synthase

1.10.3.16 dihydrophenazinedicarboxylate synthase

1.10.3.17 superoxide oxidase

1.10.5 With a quinone or related compound as acceptor

1.10.9 With a copper protein as acceptor

1.10.99 With unknown physiological acceptors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)