EC Explorer

EC 1.1.1.95 Details
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EC number
1.1.1.95
Accepted name
phosphoglycerate dehydrogenase
Reaction
3-phospho-D-glycerate + NAD+ = 3-phosphooxypyruvate + NADH + H+
Other name(s)
PHGDH (gene name), D-3-phosphoglycerate:NAD+ oxidoreductase, α-phosphoglycerate dehydrogenase, 3-phosphoglycerate dehydrogenase, 3-phosphoglyceric acid dehydrogenase, D-3-phosphoglycerate dehydrogenase, glycerate 3-phosphate dehydrogenase, glycerate-1,3-phosphate dehydrogenase, phosphoglycerate oxidoreductase, phosphoglyceric acid dehydrogenase, SerA, 3-phosphoglycerate:NAD+ 2-oxidoreductase, SerA 3PG dehydrogenase, 3PHP reductase
Systematic name
3-phospho-D-glycerate:NAD+ 2-oxidoreductase
CAS registry number
9075-29-0
Comment
This enzyme catalyses the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis. The reaction occurs predominantly in the direction of reduction. The enzyme from the bacterium Escherichia coli also catalyses the activity of EC 1.1.1.399, 2-oxoglutarate reductase [6].
History
created 1972, modified 2006, modified 2016
EC Browser
1 Oxidoreductases (9651 organisms) download 3869963 sequences with EC number 1 in fasta format download 3869963 sequences with EC number 1 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 1) as tabstop separated file
1.1.1.68 created 1965, deleted 1978 [transferred to EC 1.1.99.15, deleted 1980] show the reaction
1.1.1.70 created 1965, deleted 1978 show the reaction
1.1.1.74 created 1972, deleted 1976 show the reaction
1.1.1.89 created 1972, deleted 1976 show the reaction
1.1.1.109 created 1972, deleted 1976 show the reaction
1.1.1.139 created 1972, deleted 1978 show the reaction
1.1.1.155 created 1976, deleted 2004 show the reaction
1.1.1.171 created 1978, deleted 1984 show the reaction
1.1.1.180 created 1983, deleted 1984 show the reaction
1.1.1.182 created 1983, deleted 1990 show the reaction
1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004 show the reaction
1.1.1.242 created 1992, deleted 2001 show the reaction
1.1.1.249 provisional version created 1999, deleted 1999 (reinstated 2001 as EC 2.5.1.46) show the reaction download 1 sequences with EC number 1.1.1.249 in fasta format download 1 sequences with EC number 1.1.1.249 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version
1.1.1.253 created 1999, deleted 2003 show the reaction
2 Transferases (6622 organisms) download 6047191 sequences with EC number 2 in fasta format download 6047191 sequences with EC number 2 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 2) as tabstop separated file
3 Hydrolases (10604 organisms) download 3219244 sequences with EC number 3 in fasta format download 3219244 sequences with EC number 3 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 3) as tabstop separated file
4 Lyases (5111 organisms) download 1852335 sequences with EC number 4 in fasta format download 1852335 sequences with EC number 4 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 4) as tabstop separated file
5 Isomerases (2083 organisms) download 1146532 sequences with EC number 5 in fasta format download 1146532 sequences with EC number 5 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 5) as tabstop separated file
6 Ligases (1547 organisms) download 1713431 sequences with EC number 6 in fasta format download 1713431 sequences with EC number 6 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 6) as tabstop separated file
7 Translocases (966 organisms) download 592568 sequences with EC number 7 in fasta format download 592568 sequences with EC number 7 as tabstop The data in BRENDA allow the calculation or simulation of metabolic pathways by extracting the information of substrate/product chains and the corresponding kinetic data of the preceding and following enzymes in the Boehringer and KEGG metabolism (with the risk of including ?pathways? with non-natural compounds). version Download 2822 PDB numbers (EC 7) as tabstop separated file