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EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.1 dihydropyrimidine dehydrogenase (NAD⁺)

1.3.1.2 dihydropyrimidine dehydrogenase (NADP⁺)

1.3.1.3 Δ⁴-3-oxosteroid 5β-reductase

1.3.1.4 cortisone α-reductase

1.3.1.5 cucurbitacin Δ²³-reductase

1.3.1.6 fumarate reductase (NADH)

1.3.1.7 meso-tartrate dehydrogenase

1.3.1.8 acyl-CoA dehydrogenase (NADP⁺)

1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)

1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)

1.3.1.11 2-coumarate reductase

1.3.1.12 prephenate dehydrogenase

1.3.1.13 prephenate dehydrogenase (NADP⁺)

1.3.1.14 dihydroorotate dehydrogenase (NAD⁺)

1.3.1.15 dihydroorotate dehydrogenase (NADP⁺)

1.3.1.16 β-nitroacrylate reductase

1.3.1.17 3-methyleneoxindole reductase

1.3.1.18 kynurenate-7,8-dihydrodiol dehydrogenase

1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase

1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1.3.1.21 7-dehydrocholesterol reductase

1.3.1.22 3-oxo-5α-steroid 4-dehydrogenase (NADP⁺)

1.3.1.23 created 1972, deleted 2005

1.3.1.24 biliverdin reductase

1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

1.3.1.26 dihydrodipicolinate reductase

1.3.1.27 2-hexadecenal reductase

1.3.1.28 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase

1.3.1.30 progesterone 5α-reductase

1.3.1.31 2-enoate reductase

1.3.1.32 maleylacetate reductase

1.3.1.33 protochlorophyllide reductase

1.3.1.34 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]

1.3.1.35 phosphatidylcholine desaturase

1.3.1.36 geissoschizine dehydrogenase

1.3.1.37 cis-2-enoyl-CoA reductase (NADPH)

1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)

1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)

1.3.1.40 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase

1.3.1.41 xanthommatin reductase

1.3.1.42 12-oxophytodienoate reductase

1.3.1.43 arogenate dehydrogenase

1.3.1.44 trans-2-enoyl-CoA reductase (NAD⁺)

1.3.1.45 2′-hydroxyisoflavone reductase

1.3.1.46 biochanin-A reductase

1.3.1.47 α-santonin 1,2-reductase

1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

1.3.1.49 cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase

1.3.1.50 created 1992, deleted 1999

1.3.1.51 2′-hydroxydaidzein reductase

1.3.1.52 2-methyl-branched-chain-enoyl-CoA reductase

1.3.1.53 (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase

1.3.1.54 precorrin-6A reductase

1.3.1.55 created 1999, deleted 2004

1.3.1.56 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase

1.3.1.57 phloroglucinol reductase

1.3.1.58 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase

1.3.1.59 1,2-dihydroxy-3-methyl-1,2-dihydrobenzoate dehydrogenase

1.3.1.60 dibenzothiophene dihydrodiol dehydrogenase

1.3.1.61 terephthalate 1,2-cis-dihydrodiol dehydrogenase

1.3.1.62 pimeloyl-CoA dehydrogenase

1.3.1.63 2,4-dichlorobenzoyl-CoA reductase

1.3.1.64 phthalate 4,5-cis-dihydrodiol dehydrogenase

1.3.1.65 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase

1.3.1.66 cis-dihydroethylcatechol dehydrogenase

1.3.1.67 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase

1.3.1.68 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase

1.3.1.69 zeatin reductase

1.3.1.70 Δ¹⁴-sterol reductase

1.3.1.71 Δ^24(24¹)-sterol reductase

1.3.1.72 Δ²⁴-sterol reductase

1.3.1.73 1,2-dihydrovomilenine reductase

1.3.1.74 2-alkenal reductase [NAD(P)⁺]

1.3.1.75 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)

1.3.1.76 precorrin-2 dehydrogenase

1.3.1.77 anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]

1.3.1.78 arogenate dehydrogenase (NADP⁺)

1.3.1.79 arogenate dehydrogenase [NAD(P)⁺]

1.3.1.80 red chlorophyll catabolite reductase

1.3.1.81 (+)-pulegone reductase

1.3.1.82 (-)-isopiperitenone reductase

1.3.1.83 geranylgeranyl diphosphate reductase

1.3.1.84 acrylyl-CoA reductase (NADPH)

1.3.1.85 crotonyl-CoA carboxylase/reductase

1.3.1.86 crotonyl-CoA reductase

1.3.1.87 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase

1.3.1.88 tRNA-dihydrouridine^16/17 synthase [NAD(P)⁺]

1.3.1.89 tRNA-dihydrouridine⁴⁷ synthase [NAD(P)⁺]

1.3.1.90 tRNA-dihydrouridine^20a/20b synthase [NAD(P)⁺]

1.3.1.91 tRNA-dihydrouridine²⁰ synthase [NAD(P)⁺]

1.3.1.92 artemisinic aldehyde Δ¹¹⁽¹³⁾-reductase

1.3.1.93 very-long-chain enoyl-CoA reductase

1.3.1.94 polyprenol reductase

1.3.1.95 acrylyl-CoA reductase (NADH)

1.3.1.96 Botryococcus squalene synthase

1.3.1.97 botryococcene synthase

1.3.1.98 UDP-N-acetylmuramate dehydrogenase

1.3.1.99 (S)-8-oxocitronellyl enol synthase

1.3.1.100 chanoclavine-I aldehyde reductase

1.3.1.101 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]

1.3.1.102 2-alkenal reductase (NADP⁺)

1.3.1.103 2-haloacrylate reductase

1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)

1.3.1.105 2-methylene-furan-3-one reductase

1.3.1.106 cobalt-precorrin-6A reductase

1.3.1.107 sanguinarine reductase

1.3.1.108 caffeoyl-CoA reductase

1.3.1.109 butanoyl-CoA dehydrogenase complex (NAD⁺, ferredoxin)

1.3.1.110 lactate dehydrogenase (NAD⁺,ferredoxin)

1.3.1.111 geranylgeranyl-bacteriochlorophyllide a reductase

1.3.1.112 anthocyanidin reductase [(2S)-flavan-3-ol-forming]

1.3.1.113 (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase

1.3.1.114 3-dehydro-bile acid Δ^4,6-reductase

1.3.1.115 3-oxocholoyl-CoA 4-desaturase

1.3.1.116 7β-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase

1.3.1.117 hydroxycinnamoyl-CoA reductase

1.3.1.118 meromycolic acid enoyl-[acyl-carrier-protein] reductase

1.3.1.119 chlorobenzene dihydrodiol dehydrogenase

1.3.1.120 cyclohexane-1-carbonyl-CoA reductase (NADP⁺)

1.3.1.121 4-amino-4-deoxyprephenate dehydrogenase

1.3.1.122 (S)-8-oxocitronellyl enol synthase

1.3.1.123 8-oxogeranial reductase

1.3.1.124 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1.3.2 With a cytochrome as acceptor

1.3.3 With oxygen as acceptor

1.3.4 With a disulfide as acceptor

1.3.5 With a quinone or related compound as acceptor

1.3.7 With an iron-sulfur protein as acceptor

1.3.8 With a flavin as acceptor

1.3.98 With other, known, physiological acceptors

1.3.99 With unknown physiological acceptors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.1 With NADH or NADPH as one donor (deleted sub-subclass)

1.14.1.1 created 1961 as EC 1.99.1.1, transferred 1965 to EC 1.14.14.1, deleted 1972

1.14.1.2 created 1965, deleted 1972

1.14.1.3 created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, deleted 1972

1.14.1.4 created 1965, deleted 1972

1.14.1.5 created 1965, deleted 1972

1.14.1.6 created 1961 as EC 1.99.1.7, transferred 1965 to EC 1.14.1.6, deleted 1972

1.14.1.7 created 1965, deleted 1972

1.14.1.8 created 1965, deleted 1972

1.14.1.9 created 1965, deleted 1972

1.14.1.10 created 1965, deleted 1972

1.14.1.11 created 1965, deleted 1972

1.14.2 With ascorbate as one donor (deleted sub-subclass)

1.14.3 With reduced pteridine as one donor (deleted sub-subclass)

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor

1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor

1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated

1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated

1.14.99 Miscellaneous

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

3.1 Acting on ester bonds

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.6 Acting on acid anhydrides

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds

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Release 2023.1 (January 2023)